Banca de DEFESA: LUCAS JOSÉ SÁ DA FONSECA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : LUCAS JOSÉ SÁ DA FONSECA
DATE: 22/12/2022
TIME: 09:00
LOCAL: Sala 20 - Instituto de Ciências Biológicas e da Saúde
TITLE:

Coexisting Metabolic Syndrome in Rheumatoid Arthritis: impact on redox status and insulin resistance

KEY WORDS:

Keywords: Rheumatoid Arthritis; Metabolic Syndrome; early diagnosis; Oxidative Stress; Lipid Peroxidation.

PAGES: 170
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUBÁREA: Saúde Pública
SUMMARY:

Introduction: rheumatoid arthritis (RA) is a systemic autoimmune disease with joint compromise of destructive pattern. In its local (articular) and systemic inflammatory context, it is evident the participation of oxidative stress, a condition in which the balance between oxidants and antioxidants is lost, favoring cellular and molecular damage. Individuals with RA are at increased cardiovascular risk, being more prone to present metabolic syndrome (MetS) than in the general population. Such condition cluster various cardiometabolic risk factors, with a marked systemic inflammatory component. In this multifactorial context, the intersection points among RA, oxidative stress and MetS are still yet to be determined. Aim: to assess the impact of coexisting MetS on clinical evaluation and on systemic redox status in individuals with RA, searching for complementary biomarkers in the study of the systemic inflammatory milieu. Methodology: 26 controls (CT) from the local community and 45 individuals with RA were enrolled from the local community and from the Rheumatology outpatient facility in the Professor Alberto Antunes Teaching Hospital, Federal University of Alagoas, respectively. Diagnosis of RA was established according to the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR, 2010) classification criteria, and the diagnosis of MetS, based on those defined by the its harmonized version, 2009. After clinical assessment, patients underwent peripheral venous blood samples collection for general biochemical analyses and for the markers of oxidative stress (the enzymes superoxide dismutase, SOD; catalase, CAT; arginase, and the levels of serum lipid peroxidation by using the TBARS method). Insulin resistance was evaluated by the calculation of the TyG index. Results: the majority of volunteers was represented by females on both groups, with MetS frequency of 38.5% and 53.4% for CT and RA groups, respectively. Serum lipid peroxidation evidenced elevated levels of malondialdehyde (MDA) in RA patients compared to the CT group, and during subgroup analysis, coexisting MetS implied higher concentrations of MDA in RA individuals compared to the controls, as well as in the RA group compared to CT. The antioxidant enzyme SOD showed increased activity in the RA group in comparison to that observed in the controls with MetS, without significant differences for the CAT (both in plasma and in erythrocytes) and arginase enzymatic activities. Increased levels of HDL cholesterol and alkaline phosphatase were found in RA group compared to the controls, with no significant differences for the remaining biochemical and anthropometric parameters, and blood pressure values assessed. Subgroup analyses still showed significant differences among CT and RA groups with and without MetS for the parameters fasting glucose (lower means for RA vs RA with MetS; CT vs RA with MetS), triglycerides, TyG index (lower means for CT vs CT with MetS; RA vs RA with MetS; CT vs RA with MetS) and blood pressure values (lower systolic means for CT vs CT with MetS; higher systolic means for CT with MetS vs RA; CT with MetS vs RA with MetS). Conclusion: despite the use of pharmacological therapy with antioxidant effects, the oxidative imbalance was still evident in volunteers with RA, being worsened by coexisting MetS. Lipid peroxidation and the TyG index were shown as potential adjuvant biomarkers in the clinical assessment of these patients. MetS screening after RA diagnosis is made is crucial for early intervention on cardiovascular risk factors and for better joint and cardiovascular outcomes in patients with RA.

 

BANKING MEMBERS:
Presidente - 1545496 - LUIZA ANTAS RABELO
Interno(a) - 1851685 - ALANE CABRAL MENEZES DE OLIVEIRA
Externo(a) ao Programa - 1791653 - FLAVIO TELES DE FARIAS FILHO
Externo(a) ao Programa - 1120995 - SANDRA MARY LIMA VASCONCELOS
Externo(a) ao Programa - 058.526.204-75 - VALERIA NUNES DE SOUZA - UFPE