Therapeutic potential of natural products and their electrosynthesis.
Bioactive natural products; leishmaniasis; electrolysis; phenols
Neglected tropical diseases affect people with lower purchasing power. Among them, leishmaniasis is characterized as a group of infectious diseases caused by parasites of the genus Leishmania. This disease causes thousands of infections and deaths every year. Current treatment presents high toxicity, high cost, and low adherence. Therefore, new active molecules, such as natural products, are of paramount importance, as they are useful as sources of biologically active substances and as starting material for obtaining new bioactive products. In light of this, this thesis presents two general objectives: 1- To investigate the therapeutic potential of extracts and fractions of the plant species Cyperus rotundus Linnaeus, through chemical analyses and biological evaluation (phytochemical prospecting, extraction and isolation, redox profile, and antileishmanial activity). 2- To use eugenol as a substrate for organic electrosynthesis, aiming at obtaining useful derivatives and antileishmanial evaluation.