Evaluation of sarcopenia in the elderly and its association with glomerular filtration from serum creatinine levels
Old; Glomerular filtration rate; Sarcopenia; Creatinine
INTRODUCTION: Serum creatinine is a marker highly used to evaluate renal function, but it has limitations to evaluate elderly people, since it varies according to muscle reserve, inflammation status and diet. Over the years, muscle reserve tends to decrease, which makes the elderly more predisposed to the development of sarcopenia and the current guidelines for assessing glomerular filtration rate do not provide formulas that fit these limitations in the elderly population. OBJECTIVE: The present study aimed to evaluate whether there is an association between sarcopenia and glomerular filtration rate estimated from serum creatinine. MATERIALS AND METHODS: This was a cross-sectional study to be conducted in participants selected by convenience, in which socioeconomic, demographic, clinical, anthropometric and sarcopenia data were collected. Anthropometric evaluation included BMI, waist and calf circumferences, and bioimpedance analyses. Sarcopenia was evaluated according to the criteria proposed by the European Working Group on Sarcopenia in Older People – EWGSOP (2019). The statistical analysis used Student's t-test, chi-square test, simple linear regressions and adjusted for sex and age, all in IBM SPSS software version 21, adopting an alpha value of 5%. RESULTS: The study included 65 elderly participants with chronic kidney disease (CKD), 29 women (44.6%) and 36 men (55.4%), with 55.4% of individuals who declared themselves brown. Of the individuals evaluated, according to the GFR estimated from the formula proposed by BIS1, 87.7% were between stages 3 of Chronic Kidney Disease and 33.84% of all participants were at risk of sarcopenia. CONCLUSION: The work is still ongoing.