Banca de DEFESA: GLAUCIO MAUREN DA SILVA GERONIMO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : GLAUCIO MAUREN DA SILVA GERONIMO
DATE: 09/08/2023
TIME: 14:00
LOCAL: famed
TITLE:

Cardiovascular risk and its correlation with inflammatory biomarkers in dialytic chronic kidney disease.

KEY WORDS:

Cardiovascular risk, chronic kidney disease, inflammation, dialysis, diabetes, obesity, dyslipidemia, ferritin, IL-6, TNFα, CRP.

PAGES: 35
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

INTRODUCTION: Patients undergoing hemodialysis (HD) have a cardiovascular risk (CVR) considerably higher than that of the general population, because these individuals end up presenting specific organic and inflammatory changes, in addition to lesions induced by substitutive therapy. In people with chronic kidney disease (CKD), there is also a pro-inflammatory state that contributes substantially to the occurrence of CV events and that induces an acceleration of atherosclerosis. OBJECTIVE: To analyze the CVR and its correlation with inflammatory markers in chronic renal dialysis patients. MATERIALS AND METHODS: This is a cross-sectional observational study, carried out in 3 tertiary hospitals, both public and private, with the application of socioeconomic and clinical questionnaires (gender, age, history, lifestyle habits), laboratory evaluation (hemogram , renal function, lipid profile, C-reactive protein – CRP, ferritin), measurement of inflammatory cytokines (Interleukin 6 – IL-6 and high tumor necrosis factor – TNFα) and measurement of cardiovascular risk score (assessment of global risk score – ERG). RESULTS: A total of 149 participants with CKD on renal replacement therapy (RRT), with a mean age of 58 ± 15 years, with 76 (64.4%) male participants. The adequacy of HD was measured through Kt/V, proving to be satisfactory in the sample. 81 (54.4%) were diabetic, 133 (89.3%) were hypertensive and 32 (21.5%) were obese. 36 participants were known to have heart disease, in addition to 8 others having already presented events resulting from significant obstruction. The CVR scores showed: 105 (70.5%) at high risk and 44 (29.5%) at very high risk.

BANKING MEMBERS:
Externo(a) à Instituição - CARLOS ROMERIO COSTA FERRO
Externo(a) ao Programa - 2372248 - DANIELA MARTINS LESSA BARRETO
Interno(a) - 7530212 - MERCIA LAMENHA MEDEIROS
Presidente - 2370894 - MICHELLE JACINTHA CAVALCANTE OLIVEIRA
Interno(a) - 384.145.544-15 - SAMIR BUAINAIN KASSAR - UNCISAL
Interno(a) - 1728726 - VALFRIDO LEAO DE MELO NETO