PHYSICAL ACTIVITY, SEDENTARY BEHAVIOR, AND FRAILTY IN PEOPLE LIVING WITH HIV: A CROSS-SECTIONAL STUDY
Physical activity; Sedentary behavior; Frailty; Accelerometer; Fried phenotype
Introduction: HIV has become a chronic public health issue, and significant advances have been made in increasing the life expectancy of people living with the virus. Antiretroviral therapy (ART) has played a major role in controlling the infection and extending the life expectancy of this population. However, evidence indicates that behavioral patterns, such as engagement in physical activity, remain limited, with sedentary behaviors predominating. This inactivity may contribute to adverse health outcomes, such as frailty. Therefore, it is necessary to better understand the context of frailty and its possible associations in people living with HIV (PLHIV). Objective: To investigate the association between physical activity and sedentary behavior—both individually and combined—with frailty in PLHIV. Methods: This is an observational, cross-sectional study conducted with people living with HIV, aged 40 years or older, who have been on ART for at least six months. Participants are followed by three specialty centers located in Maceió, Alagoas, Brazil. Physical activity and sedentary behavior will be assessed using accelerometers worn continuously for seven days. Frailty will be measured based on the phenotype proposed by Fried et al. (2001). The following will be considered as confounding variables: sociodemographic and economic factors, clinical aspects related to the infection (time since diagnosis, ART use, CD4+ cell count, and viral load), presence of comorbidities, smoking, and alcohol consumption. Statistical analyses will include descriptive procedures (mean, median, standard deviation, and interquartile range) to characterize the variables of interest and predictors. To assess associations between variables, the chi-square test and binary logistic regression will be applied, stratified by sex and adjusted for potential confounding factors such as age, education, income, and clinical data. A p-value of 0.05 and a 95% confidence interval will be adopted as criteria for statistical significance. Expected results: The prevalence of frailty among PLHIV is expected to be considerably high. Therefore, understanding the role of these behaviors in the development or prevention of frailty among PLHIV is essential to support more effective care strategies.