Banca de DEFESA: LYLIAN ELLEN MILITÃO DOS SANTOS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : LYLIAN ELLEN MILITÃO DOS SANTOS
DATE: 16/02/2024
TIME: 14:00
LOCAL: meet.google.com/vqo-ciaz-ngo
TITLE:

EFFICACY OF ANTIOXIDANT THERAPY IN INFLAMMATORY BOWEL DISEASES IN MURINE MODELS: A SYSTEMATIC REVIEW

KEY WORDS:

Crohn's Disease; Ulcerative Colitis; Biomarkers; Oxidative Stress.

PAGES: 150
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Inflammatory bowel disease (IBD) has been considered a health problem throughout the world, with an incidence that has continued to grow. The current pharmacological treatment of IBD is non-specific and many patients require surgery, significantly increasing the chances of negative outcomes. In this context, new therapies that act to minimize signs and symptoms and improve quality of life have been the subject of increasingly robust research. In 2015, a systematic review was published by our study group focusing on the possibilities of antioxidant therapy in IBD and due to the low number of human trials, the review was unable to recommend or discourage the use of these alternative treatments. So, 8 years later, we intend to update this review and try to answer the question posed earlier as to whether or not antioxidant therapy works in improving patients with IBD. The search was carried out in databases such as MEDLINE (via PubMed), CENTRAL, Web of Science, EMBASE and Scopus, using a combination of keywords such as Inflammatory bowel diseases; Antioxidants; Antioxidant therapy; Crohn's Disease; Ulcerative Colitis; Biomarkers; Oxidative Stress. After applying inclusion, non-inclusion and exclusion criteria, 331 studies were selected. This current systematic review consisted of 312 animal studies carried out in murine models and 19 human studies (5.7%). The systematic review with meta-analysis in humans generated an article published in the journal Pharmaceuticals, with 8 human studies making up the meta-analysis, with the outcomes evaluated among randomized clinical trials being Superoxide Dismutase (SOD) (n=6), Total Antioxidant Capacity (CATot) (n=6) and lipid peroxidation analyzed through malondialdehyde (MDA) (n=5). In this review we can conclude that the antioxidant action is widely proven in animal models.studies.

COMMITTEE MEMBERS:
Presidente - 4364569 - FABIANA ANDREA MOURA
Externo(a) ao Programa - 3621153 - JULIANA CELIA DE FARIAS SANTOS - nullInterno(a) - 1130431 - NASSIB BEZERRA BUENO