Banca de DEFESA: THIAGO MARQUES WANDERLEY

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : THIAGO MARQUES WANDERLEY
DATE: 20/02/2024
TIME: 13:00
LOCAL: Mine auditório Úlpio de Miranda, Fanut e https://meet.google.com/arv-cejb-izq
TITLE:

INTESTINAL MICROBIOTA COMPOSITION IN PREGNANT WOMEN AND ITS INFLUENCE ON THE INCIDENCE OF ADVERSE PERINATAL OUTCOMES: SYSTEMATIC REVIEW

KEY WORDS:

Intestinal microbiology; Pregnancy; Perinatal Care.

PAGES: 68
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

During the gestational period, the intestinal microbiota has been shown to be a crucial factor for maternal-fetal health, playing a direct role in the adequate absorption of nutrients, in the connection between the brain and the intestine, and influencing metabolic processes. Furthermore, studies indicate that the intestinal microbiota can regulate fetal growth or suggest the type of delivery. Therefore, the objective of this study is to evaluate the relationship between the composition of the intestinal microbiota of pregnant women and the occurrence of adverse perinatal outcomes through a systematic review. The research was conducted using databases and platforms such as: PubMed, Embase, Lilacs, Scopus and Web of Science. Eligibility criteria included studies that evaluated the intestinal microbiota of pregnant women, regardless of health conditions, in English, Portuguese or Spanish, excluding interventions, randomized clinical trials, animal or in vitro studies, conferences and works in other languages. Furthermore, a formal protocol was registered in the PROSPERO registry. The metalogical quality of the selected studies was assessed based on the Joanna Briggs Institute Reviewers Manual. After the search, a total of 6546 articles were identified, twelve studies were selected. The studies had a sample of between 16 and 1479 women, with the participants' chronological age between 20 and 40 years. Most of the included studies used genetic extraction of nucleic acids. Regarding the results, eight neonatal outcomes were identified, including miscarriage, gestational weight gain, fetal abdominal circumference, intrauterine growth, femur length, weight, head circumference and premature birth, which were associated with more than thirty intestinal strains, such as: Betaproteobacteria, Eubacteriaceae, Enterobacteriaceae, Lachnospiraceae, Parabacteroides, Porphyromonadaceae, Ruminococcaceae and Streptococcus. According to the quality criteria adopted, it was identified that more than 80% of the articles analyzed were classified as good quality. The role of the microbiota on perinatal outcomes is reinforced by these findings, however, to fully understand the interactions between perinatal complications and the maternal intestinal microbiota, it is necessary to standardize methodologies and develop more research.

COMMITTEE MEMBERS:
Presidente - 1851685 - ALANE CABRAL MENEZES DE OLIVEIRA
Interno(a) - 4364569 - FABIANA ANDREA MOURA
Externo(a) à Instituição - CAROLINA SANTOS MELLO - UFBA