Banca de DEFESA: MARLA DE CERQUEIRA ALVES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MARLA DE CERQUEIRA ALVES
DATE: 01/07/2021
TIME: 14:00
LOCAL: https://meet.google.com/uiq-witk-ayr?pli=1&authuser=1
TITLE:

CURUMA LONGA AND INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW OF STUDIES IN ANIMAL AND HUMAN MODELS AND A METANALYSIS OF RANDOMIZED STUDIES

KEY WORDS:

Crohn’s disease. Ulcerative colitis. Turmeric. Antioxidants. Oxidative Stress

PAGES: 146
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUBÁREA: Bioquímica da Nutrição
SUMMARY:

Inflammatory bowel disease (IBD) is a chronic inflammatory manifestation characterized by episodes of attenuation and sharpness of symptoms. It comprises Crohn's disease (CD) and idiopathic ulcerative colitis (UC). It has a multifactorial character, with contribution of environmental factors, intestinal microbiota, individual genetic susceptibility, immunological and psychological factors, with emphasis on the role of inflammation and oxidative stress in its emergence. Drug treatment, which is used for a prolonged time by patients, may occur with the appearance of adverse effects, dependence and/or refractoriness to the disease. Studies have pointed out that compounds with antioxidant effect can be considered a complementary alternative treatment for IBD. In this context, Curcuma longa stands out, a perennial shrub whose rhizome is composed, among other substances, by polyphenols called curcuminoids, being curcumin, the one with the highest biological activity. This liposoluble polyphenol has antioxidant action and interact with various gene transcription factors, enzymes, inflammatory cytokines, proteins, growth factors and receptors, and additionally, does not present toxicity, even in high doses, as indicated by studies in animal models and in humans. Aiming to contribute to the analysis of the efficacy of oral use of Curcuma longa and its curcuminoids in IBD, this dissertation presents initially a literature review, which describes the characteristics of IBD, conventional treatment and implications of prolonged use, complementary alternative treatment, characterization of antioxidant and ani-inflammatory activity of Curcuma longa compounds and mechanisms of action in IBD. The main article is a systematic review with meta-analysis, whose objective was to identify the effects of Curcuma longa, curcumin or other curcuminoids on metabolic symptoms and alterations in patients and animal models of IBD. For this review, a search was carried out in the databases PubMed, Science Direct, LILACS, CENTRAL e Clinical Trials until January 2021. The following keywords were used:" inflammatory bowel disease", “ulcerative colitis", "colitis", "Crohn Disease", "curcumin”, "curcuma", "turmeric" e "Indian saffron". Articles with experimental models of colitis and randomized clinical trials (RCTs) were eligible. The primary outcome was clinical remission and secondary endoscopic remission. Of the 997 records found, 62 articles were included, 54 with animal models and 8 RCTss, of which 5 were included in the meta-analysis. 50 studies (92.59%) in animals, they observed improvement in macroscopic, histological and/or functional activity and 81.48% (n = 44) identified a decrease in oxidative and/or inflammatory biomarkers in animals treated with curcumin. Among the RCTs, the analysis of intent to treat showed that oral curcumin, associated with traditional

pharmacological treatment, was effective in inducing clinical remission (n=281, RR: 3,15 CI 95% [1,22 - 8,10] p = 0,0017; i² = 72,2%, p = 0,006) and clinical response (n=259, RR: 1,60 CI 95% [1,09 - 2,35] p = 0,0017; i² = 59,7%, p = 0,042); but not in endoscopic remission (n= 161, RR: 2,91 CI 95% [0,58 – 14,58] p = 0,195; i² = 72,7%, p = 0,026). The results found confirm that the oral prescription of Curcuma longa or curcumin, when associated with drug therapy, is effective in the treatment of patients with IBD.

BANKING MEMBERS:
Presidente - 4364569 - FABIANA ANDREA MOURA
Interno - 1130431 - NASSIB BEZERRA BUENO
Externa ao Programa - 3621153 - JULIANA CELIA DE FARIAS SANTOS
Externa ao Programa - 2120103 - MARILIA OLIVEIRA FONSECA GOULART
Externo à Instituição - ORLANDO ROBERTO PIMENTEL DE ARAUJO
Externa à Instituição - RAPHAELA COSTA FERREIRA