Banca de DEFESA: YALLI DA SILVA LEITE LESSA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : YALLI DA SILVA LEITE LESSA
DATE: 21/12/2022
TIME: 09:00
LOCAL: meet.google.com/aaj-gesu-iuj
TITLE:

EFFECTS OF PROPOLIS ON WOUND HEALING AND DIABETES MELLITUS AND ITS COMPLICATIONS: AN INTEGRATIVE LITERATURE REVIEW

KEY WORDS:

Wounds and injuries. Propolis. Apitherapy. Diabetes. Diabetic Complications.

PAGES: 63
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

These are integrative literature reviews divided into two articles that aim to analyze in vitro, preclinical and clinical studies on the use of propolis in the wound healing process and in Diabetes Mellitus and its complications. Data were selected by searching the following scientific databases: Web of Science, Pubmed Central, Scielo and Google Scholar. The search was carried out with advanced search filters, in English, using “Propolis” as the main term, associated through the Boolean operator “AND” to the following terms: a) “healing”; b) “healing”; and “Propolis”, associated through the Boolean operator “AND” to the following term: “diabetes”. In the first article, 146 studies were identified, constituting the sample with 40 studies that met the inclusion criteria of this research. Of the 40 (100%) studies analyzed, 13 (32.5%) were in vitro studies and 27 (67.5%) were preclinical and clinical studies in animals and humans. With this, 02 chapters were produced. In the second article, 280 studies were identified, constituting the sample with 30 studies. Of the 30 (100%) studies analyzed, 22 (73.3%) were in vivo and in vitro preclinical studies and 8 (26.7%) clinical studies. The in vitro, preclinical and clinical studies analyzed highlight the antimicrobial and antioxidant properties of propolis, which can help in the healing process of wounds, including diabetic wounds. In addition to causing the migration and proliferation of fibroblasts in the wound area, contributing to wound healing. In vivo studies still show evidence of its anti-inflammatory and autolytic properties. The studies in the second article bring together in vitro analyzes and in vivo animal models that show that the administration of propolis demonstrated a reduction in blood glucose levels and restoration of insulinemia with a consequent protective effect on pancreatic beta cells, high antioxidant activity, reduction of liver damage and kidneys, and improvement of the lipid profile. Clinical studies provide evidence of the effects of propolis on glucose metabolism, mainly on glycemic control, as well as improvement of the lipid profile and oxidative stress, through the hypolipidemic and antioxidant action of propolis. It can be concluded that both in vitro and in vivo studies related to the use of propolis as an alternative therapy in the healing of wounds of different etiologies, including diabetic wounds that are difficult to treat, showed positive results. Just as it is possible to conclude that propolis is a therapeutic alternative from a natural source that plays an important role in the management of diabetes and its complications.

BANKING MEMBERS:
Externo(a) ao Programa - 1885138 - ISABEL CRISTINA CELERINO DE MORAES PORTO
Externo(a) ao Programa - 3297452 - JOSÉ MARCOS DOS SANTOS OLIVEIRA
Presidente - 1488396 - TICIANO GOMES DO NASCIMENTO
Externo(a) ao Programa - 1653165 - VALTER ALVINO DA SILVA