Banca de DEFESA: THAMIRES OTAVIANO MARQUES DE SOUZA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : THAMIRES OTAVIANO MARQUES DE SOUZA
DATE: 02/02/2023
TIME: 14:00
LOCAL: Sala de Reuniões da Fanut
TITLE:

RISK OF SARCOPENIA AND ASSOCIATION WITH CLINICAL OUTCOMES IN HOSPITALIZED ELDERLY PEOPLE WITH COVID-19: A MULTICENTRIC COHORT STUDY IN THE BRAZILIAN NORTHEAST

KEY WORDS:

SARC-CoV-2. Aging. Muscle Strenght. Mortality

PAGES: 89
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Physiological alterations of aging, such as immunosenescence, changes in the respiratory system and the burden of chronic non-communicable diseases, were related to the mortality of this population during the pandemic caused by the coronavirus. In addition, sarcopenia, a predominantly geriatric disease, can also be related to unfavorable outcomes in this population. It is known that the presence of sarcopenia in hospitalized patients can contribute to a longer hospital stay, higher incidence of infections and mortality. Thus, the elderly population seems to be more susceptible to severe COVID-19 and its worst clinical outcomes. This dissertation is structured in three sections, being an introduction chapter, a literature review chapter and a chapter composed of a scientific article. The original article entitled “Association between risk of sarcopenia and clinical complications of covid-19 in hospitalized elderly people: results of a multicenter study”, aimed to verify whether the risk of sarcopenia assessed by the Sarcopenia Risk Screening questionnaire, in elderly people diagnosed with COVID-19 is associated with demand for intensive care, mechanical ventilation and death. This is a multicenter cohort study carried out in all states in the northeast region of Brazil. Which included elderly people (> 65 years old) hospitalized with laboratory-confirmed COVID-19. The risk of sarcopenia was associated with outcome variables: demand for intensive care, need for mechanical ventilation and death. For this, logistic regressions were performed with the following adjustment variables: age, sex, household income, hypertension, diabetes, cardiovascular disease, chronic obstructive pulmonary disease and body mass index. The risk of sarcopenia in elderly patients with COVID-19 increased the odds of ICU admission by more than 2-fold (p<0.001), the odds of mechanical ventilation by about 5-fold (p<0.001), and the odds of death by more than 3-fold (p<0.001). Thus, it is concluded that the pre-existing risk of sarcopenia was a predictor of unfavorable clinical outcomes in elderly people hospitalized with COVID- 19.

BANKING MEMBERS:
Presidente - 1727406 - JOAO ARAUJO BARROS NETO
Externo(a) ao Programa - 3621153 - JULIANA CELIA DE FARIAS SANTOS
Interno(a) - 1130431 - NASSIB BEZERRA BUENO