Banca de DEFESA: PALLOMA RAFAELLY MARIANO DE MATTOS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : PALLOMA RAFAELLY MARIANO DE MATTOS
DATE: 14/02/2023
TIME: 13:30
LOCAL: meet.google.com/itx-odat-cpi
TITLE:

THE ROLE PLAYED BY ORAL ANTIOXIDANT THERAPIES IN PREVENTING AND TREATING PREECLAMPSIA: AN UPDATED META-ANALYSIS

KEY WORDS:

Pregnancy; Preeclampsia; Oxidative stress; Antioxidant.

PAGES: 112
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Preeclampsia (PE) is considered one of the main causes of maternal and fetal morbidity and mortality worldwide and, despite its importance to maternal and fetal health, there is still no consensus in the literature about the best clinical and nutritional strategies for its prevention and/or treatment. However, even in the face of controversy, antioxidant supplementation has been considered to attenuate damage caused by oxidative stress involved in the pathophysiology of the disease. This dissertation initially presents a literature review chapter discussing the etiological aspects and the involvement of oxidative stress in the development of PE, as well as the therapeutic role of antioxidants on the disease. Then, an original article is presented whose objective is to perform an updated meta-analysis of oral antioxidant therapies and determine whether they are effective in the prevention and/or treatment of PE. This is a meta-analysis where PubMed, Cochrane Central Register of Controlled Trials, LILACS (Latin American and Caribbean Literature in Health Sciences), Web of Science, and ScienceDirect databases were searched and the studies considered eligible were searched, based on the inclusion criteria, data extraction, and risk of bias analysis was performed. For statistical analyses, we used the calculation of the relative risk (RR) for each outcome, between groups, the Mantel-Haenszel method for assigning the weights of each study, and the calculations were based on a random effects model, adopting a value α=0.05. To assess heterogeneity, the Cochran Q test was used, and inconsistency was tested using the I² statistic. A P < 0.1 was adopted for the Cochran Q test when heterogeneity was considered important. Significant results related to the incidence of PE in prevention studies were identified (RR: 0.86, 95% Confidence Interval: [ 0.75, 0.99] , p = 0.03; I ² = 44%, p = 0.02) and in outcomes associated with treatment studies, only intrauterine growth restriction was shown to have significant effects.

BANKING MEMBERS:
Presidente - 1851685 - ALANE CABRAL MENEZES DE OLIVEIRA
Externo(a) à Instituição - CAROLINA SANTOS MELLO
Interno(a) - 1120995 - SANDRA MARY LIMA VASCONCELOS