Banca de DEFESA: MARIA GRACYELLA FERREIRA DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MARIA GRACYELLA FERREIRA DA SILVA
DATE: 11/07/2023
TIME: 14:00
LOCAL: https://meet.google.com/wrz-nxms-rki
TITLE:

Placental and umbilical cord levels of vascular endothelial growth factor in pregnancies with preeclampsia and its relationship to maternal and fetal outcomes

KEY WORDS:

Race factor; Extrait placentaire; Umbilical Cord; Apgar Score.

PAGES: 72
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

The objective of this study is to analyze the levels of Vascular Endothelial Growth Factor (VEGF) in the placenta and umbilical cord and to evaluate their relationship with the presence of maternal and fetal outcomes in pregnancies with PE. Cross-sectional study carried out with pregnant women with and without PE. VEGF levels were obtained from placental and umbilical cord extracts using the enzyme-linked immunosorbent assay (ELISA), which were compared according to maternal and fetal variables. Statistical analyzes were performed using the Statistical Package for Social Sciences (SPSS) version 20.0, adopting an alpha equal to 5%. One hundred pregnant women with PE and fifty without the disease were evaluated, with no statistical difference regarding placental and umbilical cord VEGF levels between these groups (p>0.05). However, there was statistical significance between placental VEGF levels and black race (82.412 pg/mL PE vs 788.183 pg/mL control, p of interaction 0.02) and low apgar at the 5th minute (1806.498 pg/mL vs 57.317 pg/mL, p of interaction 0.01). The ratio between placental/umbilical cord VEGF levels was statistically significant with birth weight (p of interaction 0.04). Placental VEGF levels were related to maternal variables and fetal outcomes, however the ratio between placental/umbilical cord VEGF levels between the groups demonstrated that there is a possible adaptive mechanism between the levels of this marker and the different gestational tissues, in addition to having proved to be sensitive for detecting other outcomes associated with VEGF levels, emphasizing the importance of concomitant analysis between placenta and umbilical cord in pregnancies with PE.

BANKING MEMBERS:
Presidente - 1851685 - ALANE CABRAL MENEZES DE OLIVEIRA
Interno(a) - 4364569 - FABIANA ANDREA MOURA
Externo(a) à Instituição - RAPHAELA COSTA FERREIRA - Tiradentes