Banca de DEFESA: AMANDA LARISSA DIAS PACHECO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : AMANDA LARISSA DIAS PACHECO
DATE: 28/03/2024
TIME: 14:00
LOCAL: ICBS - Sala 19
TITLE:

Role of cannabidiol in the behavior, lymphoid organs and redox state of rats exposed to crack cocaine during gestational period

KEY WORDS:

Gestation; cannabis sativa; alternative therapy; comorbidities.

PAGES: 72
BIG AREA: Ciências Biológicas
AREA: Fisiologia
SUBÁREA: Fisiologia de Órgãos e Sistemas
SPECIALTY: Neurofisiologia
SUMMARY:

Crack cocaine, a psychoactive substance derived from cocaine, is a serious public health problem, with both physical and mental effects. This situation becomes even more critical when pregnant women continue to use crack cocaine, as its consumption brings deleterious effects on fetal development and teratogenic outcomes, as well as long-term impairments in early childhood. Children exposed to crack cocaine during pregnancy have a higher incidence of neurological disorders and behavioral changes. Much of these effects have been associated with alterations in oxidative stress levels and neurotoxicity. The lack of effective pharmacological therapies to treat these neurological effects underscores the need for innovative interventions. Cannabidiol (CBD)-rich Hemp Extract, derived from Cannabis sativa, emerges as a promising therapeutic substance for neurological disorders, exhibiting anxiolytic, antidepressant, antiepileptic, and antioxidant properties. Additionally, CBD demonstrates anti-inflammatory and antioxidant effects, offering potential protection against oxidative stress. Innovatively, this study evaluated the effect of CBD treatment on alterations (in behaviors, oxidative stress, and lymphoid organs) induced in offspring after intrauterine exposure to crack cocaine (PN-Crack) in an animal model (CEUA #28/2021). Pregnant rats (60-90 days) were exposed to crack cocaine (200 mg) or ambient air daily from the 5th to the 21st day of gestation. The offspring of the animals were orally treated with CBD (30 mg/kg) or 0.9% saline solution (VEH) for 20 days, forming the four experimental groups. Subsequently, the animals underwent behavioral tests, locomotor activity, and after the tests, surgical resection of the brain (for evaluation of oxidative stress), thymus, and spleen (weighed and their cellularity counted). Our results demonstrated that CBD partially blocked behavioral changes and oxidative stress components induced after PN-Crack. Thus, our work suggests that CBD may represent an innovative strategy to improve the survival and quality of life of children exposed to crack cocaine. Although more studies are needed, the use of CBD in the future may present itself as an alternative therapy to improve the prognosis of children exposed to crack cocaine during pregnancy.

COMMITTEE MEMBERS:
Presidente - 1974414 - OLAGIDE WAGNER DE CASTRO
Interno(a) - 1556562 - ABELARDO SILVA JUNIOR
Externo(a) ao Programa - 1916144 - GILBERTO COSTA JUSTINO - UFALExterno(a) ao Programa - 1148653 - IGOR SANTANA DE MELO - UFALExterno(a) à Instituição - MARIA DOLORES ESTELITA LÓPEZ GARCÍA