Banca de QUALIFICAÇÃO: CLARISSIANE SERAFIM CARDOSO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : CLARISSIANE SERAFIM CARDOSO
DATE: 21/07/2021
TIME: 14:00
LOCAL: Google Meet
TITLE:

Investigation of a Glass Ionomer Cement modified from the incorporation of Fluorinated Lamellar Double Hydroxide (HDL-F): an in vitro and in silico study

KEY WORDS:

fluoride; layered double hydroxide; glass ionomer cement

PAGES: 105
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUBÁREA: Materiais Odontológicos
SUMMARY:

The study aimed to develop a conventional hybrid glass ionomer cement (GIC) from the incorporation of a fluoridated layer double hydroxide (HDL-F) clay in concentrations of 1, 2, 5 and 10% by weight, aiming at improving strength. mechanical, antimicrobial and fluoride release profile (F-). Specimens (6 x 4mm) were made, crushed and sieved to obtain the powder and further characterized using X-ray diffraction (DRX), Fourier transform infrared spectroscopy (FTIR) and spectrometry. energy dispersive X-ray fluorescence (EDX). For mechanical evaluation, the axial compression test was performed according to the ISO 9917-1:2007 standard. For analysis of F- release, specimens were submerged in deionized water, which was replaced at pre-set times of 6h, 1, 2, 3, 5, 7, 14 and 21 days. The solution obtained was reserved for quantification of F- by a specific electrode of this ion. Release profiles were evaluated using kinetic models such as: zero order, first order, Higuchi and Korsmeyer-Peppas. The in silico analysis was performed in order to validate the in vitro mechanical analysis. The groups were designated as follows: CIV/HDL-F 1; CIV/HDL-F 2; CIV/HDL-F 5, CIV/HDL-F 10 and the clay-free control group: G0 = CIV, with variations in the conditioning of the specimens (temperature, time and humidity). Structurally, clay was crystalline different from CIV and from hybrid products that followed an amorphous pattern. Spectral bands were observed in the FTIR, characteristic of the studied materials. Elemental analysis of EDX revealed the predominance of magnesium and aluminum for clay and for cement calcium, silicon, aluminum, phosphorus and sodium were seen. For the products, in addition to these, magnesium was present, characterizing the presence of clay in the composites. Axial compression analysis revealed less resistant hybrid products compared to the control. The release of fluoride for the products revealed a slow and sustained release and the kinetic model that best fit was the Korsmeyer-Peppas with Fick and non-Fick formulations with slow diffusion through the outer layer of the material. It was concluded that the hybrid civ’s were easily obtained and characterized, showing a good fluoride release behavior and may become a strong ally in clinical practice with a view to reducing initial and secondary caries lesions.

BANKING MEMBERS:
Presidente - 1527220 - CAMILA BRAGA DORNELAS
Interna - 2022362 - ANA CATARINA REZENDE LEITE
Externa ao Programa - 1885138 - ISABEL CRISTINA CELERINO DE MORAES PORTO
Externa ao Programa - 1582140 - KAROLINE ALVES DE MELO MORAES
Externo ao Programa - 1797785 - LUCAS MEILI