Banca de QUALIFICAÇÃO: ELLYDA FERNANDA LOPES COSTA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ELLYDA FERNANDA LOPES COSTA
DATE: 04/11/2021
TIME: 13:30
LOCAL: Google meet
TITLE:

Modulatory effect of Lithium on mania-like behavior induced by photoperiodic variations

KEY WORDS:

Bipolar Disorders; Suicide; Photoperiod; Lithium; Circadian Rhythms.

PAGES: 43
BIG AREA: Ciências da Saúde
AREA: Medicina
SUBÁREA: Psiquiatria
SUMMARY:

Bipolar disorder (BD) is a chronic mood disorder, affecting approximately 2-3% of the global population. Mania is a cardinal feature of BD and is characterized by symptoms as exposure to risk and impaired decision-making. Epidemiological studies show higher occurrence of hospitalizations for manic episodes in periods of accentuated increments in day length, or photoperiod. Consistently, preliminary studies performed by our group indicate that a gradual increase of the photoperiod is associated with a mania-like behavior in C57BL/6 mice. The hypothesis is that gradual variations in photoperiod modulate the circadian rhythms in brain regions associated with mood disorders. Lithium (Li) is a mood stabilizer used in the treatment of bipolar disorders in humans with antimanic and antidepressant properties. Furthermore, Li treatment modulates mood-related behavior in rodents. The aim of this work is to validate the photoperiodic induced mania-like animal model by pharmacologically testing lithium as a mood stabilizer. The animals that were used in the present study are male C57BL/6J mice, distributed into the three groups: (1) Equatorial (Eq), (2) DTM (Daylength Transition Model) and (3) DTM-Li. The animals of Eq group were exposed to CE12:12. The DTM group consists of mice exposed to a regime of gradual photoperiodic variations (30min at the beginning and 30 min at the end of light phase/day) from 08h:16h CE to a 16h:8h CE, with food and water ad libitum. The DTM-Li group animals were submitted to the same photoperiodic protocol but Lithium Chloride was administered in drinking water for eight days, from the first day to the last day of the DTM regime. Elevated Pluz Maze, Open Field Test, Forced Swimming Test and Hole Board were performed to evaluate hyperactivity, anxiety, risk-taking, depression and mania. The date were analyzed using the ANOVA (post-hoc Tukey), using prism 8 software, with a significance cut-off value of P < 0.05 and 95% confidence interval.. The animals in the DTM-Li group showed a decrease in risk exposure evaluated by the elevated plus maze test; exploratory and hyperlocomotion behaviors, assessed through behavioral tests, when compared to the TMD and similar to the control group. The findings demonstrate that administration of lithium stabilizes mood and prevents the mania-like behavior observed in the experimental condition. This study contributes to the establishment of a new model for bipolar disorder based on the manipulation of ambient light.

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Presidente - 1544773 - TIAGO GOMES DE ANDRADE
Interno - 2033893 - MARCELO DUZZIONI
Interno - 1974414 - OLAGIDE WAGNER DE CASTRO