Banca de DEFESA: JOÃO FLÁVIO MONTEIRO SILVA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : JOÃO FLÁVIO MONTEIRO SILVA
DATE: 30/03/2022
TIME: 14:00
LOCAL: https://meet.google.com/grj-pzpw-csu (video confeência)
TITLE:

Leishmanicidal activity semi-synthetic compounds: a proposal for new strategies in the treatment of leishmaniasis

KEY WORDS:

Leishmaniasis, semi synthetic compounds, New drugs.

PAGES: 80
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Leishmaniasis is a set of diseases caused by protozoa of the genus Leishmania. They manifest through varied symptoms classified into two major branches: tegumentary and visceral disorders, which in the American continent are mainly associated with L. amazonensis and L. chagasi, respectively, despite being caused by different species around the world. They are considered neglected endemic diseases, as they occur mainly in populations under socioeconomic vulnerability. The association of the disease with morbidities or other infectious diseases such as AIDS has a great impact on the duration, intensity and outcome of the disease, and current treatments are associated with a high risk of therapeutic failure and toxicity. With the search for improvement in the pharmacotherapy of leishmaniasis, new technologies such as the synthesis of drugs from bioactive substances are used by the public initiative of Federal Universities for the development of new drugs. The objective of this work was to evaluate the pharmacological potential of semi-synthetic derivatives through their activity against L. amazonensis and L. chagasi and the possible cytotoxicity in J774.A1 macrophages. Derivatives with different known bioactive groups were tested, such as triazol-amino-quinones and hydrazones. The results indicated leishmanicidal activity among the derivatives. For the most part, the toxicity profile was concentration-dependent. It is suggested the structural modification of some derivatives and the selection of those that can be explored even in higher concentrations in subsequent experiments. The development of new drugs continues to be a strategic branch of the fight against leishmaniasis, although joint actions in other spheres within the scope of public health also need to act in parallel to eradicate the diseases.

BANKING MEMBERS:
Presidente - 1358530 - MAGNA SUZANA ALEXANDRE MOREIRA
Interna - 2272670 - ALINE CAVALCANTI DE QUEIROZ
Externo ao Programa - 1506475 - ALYSSON WAGNER FERNANDES DUARTE
Externo ao Programa - 1369387 - JOAO XAVIER DE ARAUJO JUNIOR
Externa à Instituição - CAMILA DE BARROS PRADO MOURA SALES - CESMAC