Banca de DEFESA: BRUNA BRANDAO DOS SANTOS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : BRUNA BRANDAO DOS SANTOS
DATE: 05/12/2022
TIME: 09:00
LOCAL: virtual
TITLE:

SOCIODEMOGRAPHIC, MENTAL HEALTH AND GENETIC PROFILE OF TNF-A (-308 G>A), IL-10(-819 C>T) AND 5-HTT (rs2020933 A>T) SNPs IN ALCOHOL USERS.

KEY WORDS:

Alcohol-Related Disorders; Mental Disorders; Genetic Polymorphism; Serotonin.

PAGES: 105
BIG AREA: Ciências da Saúde
AREA: Enfermagem
SUBÁREA: Enfermagem de Saúde Pública
SUMMARY:

The use of psychoactive substances is considered a health problem worldwide, among these substances is alcohol. In addition, studies point to a relationship between alcohol use and mental health disorders. From the gender point of view, the use of alcohol by women is linked to social factors and stigmatization. Several neurotransmitters and their respective pathways are involved in the effects caused by alcohol in the body, such as: serotonergic, GABAergic and glutamatergic. In this sense, it is noteworthy that polymorphisms may be involved in susceptibility or protection to alcohol use. Therefore, the objective of this study is to analyze the sociodemographic, mental health and genetic characteristics of polymorphisms in the IL-10 -819 C>T (rs1800871), TNFA -308 G>A (rs1800629) and 5-HTT (rs2020933) genes. in individuals using alcohol. This was a cross-sectional study with alcohol users. The identification of the genotypes of the genes: IL-10 -819 C>T (rs1800871), TNFA -308 G>A (rs1800629) and 5-HTT (rs2020933 A>T) was determined by means of a timed polymerase chain reaction. real (qPCR). For statistical analysis, the IBM SPSS software version 22.0 was used. P values less than 0.05 were considered statistically significant. The study consisted of a total of 91 individuals, 31 belonging to the case group, alcohol users, and 60 to the control group (non-alcohol users). As for sociodemographic characteristics, the mean age was 29.8 years for women and 32.9 years for men. Most living in urban areas, own house or apartment, single and brown. High levels of impulsivity and aggression were identified. the most prevalent mental disorders in the population studied were: Current major depressive episode 84.2% (n=16), suicide risk 63.1% (n=11), Antisocial personality disorder 73.6% (n=14) and generalized anxiety 52.6% (n=10). No statistically significant values were found for the TNFA -308 G>A (rs1800629) and 5-HTT (rs2020933) polymorphisms, while for the IL-10 (-819 C>T) polymorphism the T allele (18.2%) was associated with reduced risk for alcohol consumption in women (OR=0.203; CI=0.638; p=0.011).

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