Banca de DEFESA: YNGRID MICKAELLI OLIVEIRA DOS SANTOS

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : YNGRID MICKAELLI OLIVEIRA DOS SANTOS
DATE: 31/03/2023
TIME: 14:00
LOCAL: ICBS - Sala 19
TITLE:

Ontogenic, immunological and behavioral changes from exposure to crack during the gestational period

KEY WORDS:

crack; maternal behavior; pregnancy; spleen; cell death.

PAGES: 58
BIG AREA: Ciências Biológicas
AREA: Fisiologia
SUBÁREA: Fisiologia de Órgãos e Sistemas
SPECIALTY: Neurofisiologia
SUMMARY:

Crack cocaine has potentiated actions in nervous system (CNS), due to the substances generated by its pyrolysis, increasing the bioavailability, the speed of metabolism and drug addiction. The increased consumption of psychoactive drugs by women of childbearing age has generated many challenges in the public health. Crack cocaine use by pregnant women has been correlated with a higher incidence of premature fetuses, CNS malformations and cell damage, as well as changes in the immune system. Here we evaluated the effects of gestational exposure to crack cocaine in pregnant rats on placental cells, immune organs, maternal and anxiety-like behavior, and sensorimotor reflex development. Pregnant rats were exposed to air or crack cocaine (200 mg, for 10 min) from the 5^th to the 9^th day or until the end of pregnancy. Gestational exposure to crack cocaine increased trophoblastic cell death and reduced viable cells, associated with reduced growth of ectoplacental cones. In addition, exposure to crack cocaine during pregnancy reduced the relative weight of the spleen, as well as the number of total splenocytes and CD8+ T lymphocytes subpopulations. Finally, exposure to crack led to anxiogenic-like behavior and negligence in maternal care. Taken together, our findings provide insight into gestational changes promoted following exposure to crack cocaine and support future clinical interventions and treatments.

BANKING MEMBERS:
Presidente - 1974414 - OLAGIDE WAGNER DE CASTRO
Interno(a) - 1556562 - ABELARDO SILVA JUNIOR
Interno(a) - 2269479 - CAROLINNE DE SALES MARQUES
Externo(a) à Instituição - EUCLIDES MAURÍCIO TRINDADE FILHO - CESMAC
Externo(a) à Instituição - KAROL FIREMAN DE FARIAS