Banca de DEFESA: HIGOR VINICIUS RODRIGUES SPINELI SILVA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : HIGOR VINICIUS RODRIGUES SPINELI SILVA
DATE: 13/12/2023
TIME: 09:00
LOCAL: Instituto de Ciências Biológicas e da Saúde - Sala 19
TITLE:

EFFECTS OF ACUTE CAFFEINE INGESTION AT DIFFERENT TIMES, ASSOCIATED WITH THE 163 C>A POLYMORPHISM OF CYP1A2 (rs762551), ON PHYSICAL AND SPORTS PERFORMANCE IN VOLLEYBALL ATHLETES: A METABOLOMIC ANALYSIS

KEY WORDS:

Xanthine; genotype; nutritional supplementation; ergogenic effects; Cytochrome P450 1A2; caffeine; metabolomics;

PAGES: 100
BIG AREA: Ciências da Saúde
AREA: Educação Física
SUMMARY:

The present study constructed a narrative review to analyze the current state of the art on caffeine supplementation (CAF) and the CYP1A2 163 C>A polymorphism on aerobic and anaerobic physical performance. The findings indicate that CAF improves performance in aerobic tests, but the results of the interaction with the genotype are still very controversial and require more studies with better methodological qualities and with higher sample sizes to have a more reliable population inference. Regarding anaerobic performance, the analysis shows that CAF appears to have an influence in relation to the dosage, duration of exercise and its fatigue-inducing profile. In short-duration exercises with a low fatigue-inducing profile, the results of CAF are less effective and more controversial, while for exercises with a slightly longer duration and with a greater fatigue-inducing profile, CAF has a more precise benefit. Regarding polymorphism in anaerobic performance, the results are still very controversial, but the few articles that found a significant interaction between CAF supplementation and the CYP1A2 genotypes studied, showed that AA homozygotes seem to have more influence on performance. However, although polymorphism studies associate the different genotypes of CYP1A2 as possible causes of divergent responses to CAF supplementation, especially in anaerobic exercise, no work has proven whether or not there are different responses in human metabolism with these polymorphisms. The present study analyzed the urine of volleyball athletes to identify the metabolomic profile in sports and performance situations with different moments of CAF supplementation and placebo. It was identified that, regardless of CAF, the human body has a different metabolic profile for the AA and AC genotype of CYP1A2 and this can help to elucidate many of the gaps present in the literature on CAF supplementation and genetic polymorphisms. Despite large variations in the metabolic profile, this factor is not statistically reflected in sports practice, and does not cause large variations in physical performance. Technical actions in volleyball, however, seem to be more effective, economical and more precise (with a lower rate of errors) when supplemented with CAF, whether at 30 CAF, 60 or 90 CAF of tests, compared to placebo, which significantly increased the number of technical actions, whether right or wrong. We conclude that the metabolic profile of subjects with different genotypes of 163 C>A of CYP1A2 is different when compared, however, this difference does not seem to be sufficient to change physical and sports performance.

COMMITTEE MEMBERS:
Presidente - 1878467 - GUSTAVO GOMES DE ARAUJO
Interno(a) - 2579081 - DANIEL LEITE GOES GITAI
Interno(a) - 3138872 - FILIPE ANTONIO DE BARROS SOUSA
Externo(a) ao Programa - 1311365 - THAYS DE ATAIDE E SILVA - UFALExterno(a) à Instituição - ADRIANO EDUARDO LIMA DA SILVA - UTFPR