Banca de DEFESA: KELLYSSON BRUNO OLIVEIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : KELLYSSON BRUNO OLIVEIRA
DATE: 18/12/2023
TIME: 09:00
LOCAL: ICBS - Sala 19
TITLE:

SARS-CoV-2 and Hypertension: Evidence Supporting Invasion into the Brain Via Baroreflex Circuitry and
the Role of Imbalanced Renin-Angiotensin- Aldosterone-System

KEY WORDS:

SARS-CoV-2, hypertension, baroreflex, angiotensin II

PAGES: 15
BIG AREA: Ciências Biológicas
AREA: Fisiologia
SUBÁREA: Fisiologia de Órgãos e Sistemas
SPECIALTY: Neurofisiologia
SUMMARY:

Hypertension is considered one of the most critical risk factors for COVID-19. Evidence suggests that SARS-CoV-2 infection produces intense effects on the cardiovascular system by weakening the wall of large vessels via vasa-vasorum. In this commentary, we propose that SARS-CoV-2 invades carotid and aortic baroreceptors, leading to infection of the nucleus tractus solitari (NTS) and paraventricular hypothalamic nucleus (PVN), and such dysregulation of NTS and PVN following infection causes blood pressure alteration at the central level. We
additionally explored the hypothesis that SARS-CoV-2 favors the internalization of membrane ACE2 receptors generating an imbalance of the renin-angiotensin-aldosterone system (RAAS), increasing the activity of angiotensin II (ANG-II), disintegrin, and metalloproteinase 17 domain (ADAM17/TACE), eventually modulating the integration of afferents reaching the NTS from baroreceptors and promoting increased blood pressure. These mechanisms are related to the increased sympathetic activity, which leads to transient or permanent hypertension associated with
SARS-CoV-2 invasion, contributing to the high number of deaths by cardiovascular implications.

COMMITTEE MEMBERS:
Interno(a) - 1298235 - EMILIANO DE OLIVEIRA BARRETO
Interno(a) - 1974414 - OLAGIDE WAGNER DE CASTRO
Externo(a) à Instituição - VICTOR RODRIGUES DOS SANTOS - UFMG