Banca de QUALIFICAÇÃO: FELIPE FELIX COSTA LIMA DA SILVEIRA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : FELIPE FELIX COSTA LIMA DA SILVEIRA
DATE: 24/04/2024
TIME: 09:00
LOCAL: Videoconferência
TITLE:

Interactive effects of microplastics and methylparaben in developing zebrafish (Danio rerio)

KEY WORDS:

contaminants of emerging concern, embryotoxicity, ecotoxicology, conservatives

PAGES: 20
BIG AREA: Ciências Biológicas
AREA: Biologia Geral
SUMMARY:

Among the contaminants of emerging concern (CECs) are parabens, a class of molecules derived from 4-hydroxybenzoic acid which are commonly used as preservatives in industrial preparations. Their potential for endocrine disruption has been studied for over two decades, and in the most recent research new toxicity endpoints have been observed, such as the impairment of embryological development in fish species. Microplastics, in turn, are particles up to 5 mm in diameter made up of various types of organic polymers, among which polyethylene (PE) is one of the most widely used and found in aquatic environments. These particles have the ability to adsorb substances on their surface, acting as a "Trojan horse" that can modify the toxicity of the adsorbed molecules. This study sought to understand the toxicity of the interaction between methylparaben (MeP) and polyethylene microplastics (MPPE) on zebrafish (Danio rerio) in its early stages of development. To achieve this, the embryolarval toxicity test (ZELT), morphometric analysis and behavioral analysis were carried out using concentrations of 0.01, 0.1 and 1 µM of MeP separately or in a mixture with a suspension of MPPE at a concentration of 3.4 mg/L. There were no differences between the treatments regarding mortality, spontaneous movements and hatching rate during the 144 hours of experiment, but there was a significant difference in the heart rate of groups exposed to the concentrations of parabens in comparison to controls and to the group exposed to MPPE alone, which is an evidence that MeP is capable of eliciting cardiotoxicity in zebrafish embryos at environmentally relevant concentrations. 

COMMITTEE MEMBERS:
Presidente - 1265581 - LAZARO WENDER OLIVEIRA DE JESUS
Interno(a) - 2269625 - ROBSON GUIMARAES DOS SANTOS
Interno(a) - 1544255 - TACIANA KRAMER DE OLIVEIRA PINTO
Externo(a) à Instituição - GUILHERME MALAFAIA PINTO - IF Goiano
Externo(a) à Instituição - CESAR KOPPE GRISOLIA - UnB