Banca de QUALIFICAÇÃO: LUCAS FERNANDO DE LIMA COSTA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : LUCAS FERNANDO DE LIMA COSTA
DATE: 26/02/2024
TIME: 09:00
LOCAL: SALA DE PÓS-GRADUAÇÃO - PPGQB
TITLE:

Synthesis of coumarins and study of their pharmacological activity

KEY WORDS:

Synthesis, Coumarins; Aedes aegypti; Bioactive Insecticides and Toxicity.

PAGES: 50
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUMMARY:

Aedes aegypti is the main vector responsible for the transmission of arboviruses such as zika, chikungunya, dengue and yellow fever. The repeated occurrence of epidemics caused by recent arboviruses reinforces the call for action against these viral diseases and the need for vector control tools. Regarding the control of this vector, it is currently done through the use of insecticides, however studies reveal that they are toxic, carcinogenic and the larvae are already resistant. In this way, the development of new bioactive compounds proves to be a sustainable and low-toxic alternative for the development of larvicides. The use of coumarins as larvicides has potential as an alternative to conventional mosquito control methods. These compounds act by inhibiting the AChE and GSTs enzymes, interfering with the mosquito's metabolism and causing its death, but additional studies are still needed to evaluate their efficacy and safety in different field conditions. The in silico study was carried out using enzymes homologous to Acetylcholinesterase (AchE) and Glutathione S-transferase (GST). Compounds 1a (R1=R2=H, R3=COOEt) and 1d (R1=R2=OH, R3=COOEt) presented the best score values for the AChE and GST enzymes, respectively. The methodology for the synthesis of coumarin derivatives is being carried out via the Knoevenagel reaction, the compounds of the R3=COOET series were isolated and characterized by 1H, 13C and FTIR NMR, the derivatives of the R3=COMe and R3=CN series are still in the process of synthesis and purification. The bioassays will be carried out using a qualitative and quantitative approach using fourth instar larvae.

COMMITTEE MEMBERS:
Presidente - 2089941 - DIMAS JOSE DA PAZ LIMA
Interno(a) - 1006306 - JADRIANE DE ALMEIDA XAVIER
Externo(a) à Instituição - Verônica Diniz da Silva