Banca de DEFESA: JEFERSON SANTANA URSULINO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : JEFERSON SANTANA URSULINO
DATE: 25/08/2021
TIME: 08:30
LOCAL: meet.google.com/wqd-ayed-cux
TITLE:

IDENTIFICATION OF URBAN AND PLASMATIC METHODS OF THE POPULATION OF THE POPULATION SURROUNDING THE LAGUNA MUNDAÚ (MACEIÓ-AL) EXPOSED TO INORGANIC CONTAMINATIONS FOR METABOLIC MEMBERS

KEY WORDS:

Metabonomics, Metabolome, Exposure to the aquatic environment, 1H NMR spectroscopy, Heavy Metal.

PAGES: 103
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUMMARY:

Expanding environmental studies is critical to understanding the crucial role the environment plays in population health. Inorganic contaminants, especially mercury, can accumulate in organs, which pose health risks. We showed in another study that fishermen (Exposed group) from Lagoa Mundaú (Maceió – Al) have higher concentrations of total mercury in blood (0.73 - 48.38 µg L-1 ) and urine (0.430 - 10.15 µg L-1 ) than the total mercury concentrations in the blood (0.29 - 17.30 µg L-1 ) and urine (0.210 - 2.65 µg L-1 ) of the control group. Our objective was to create metabolomic models capable of identifying the toxic effects of mercury found in the urine and blood of fishermen. Hydrogen nuclear magnetic resonance was used to determine urine and plasma metabolites. The results showed that the two metabolomic models were able to reveal patterns through principal component analysis (PCA), Heatmap and orthogonal least squares discriminant analysis (OPLS-DA). And the significant metabolites (biomarkers) were selected by the combination based on the volcano plot at a fold change limit (FC) > 2 and t test p-value limit < 0.05. Therefore, fishermen had higher concentrations of glutamate, creatinine, formate and glutamine in plasma, and glycine and trimethylamine oxide (TMAO) in urine. These results indicate that mercury in fishermen's blood may be responsible for causing disturbances in energy metabolism (Krebs cycle and fatty acid oxidation), glutathione biosynthesis, indicating oxidative stress in blood cells, and also, creatine pathway accompanied by highs TMAO levels, supporting indicative of renal dysfunction.

BANKING MEMBERS:
Externo à Instituição - FRANCISCO JAIME BEZERRA MENDONÇA JÚNIOR - UEPB
Externo à Instituição - RICARDO OLIVEIRA DA SILVA - UFPE
Interna - 2022362 - ANA CATARINA REZENDE LEITE
Interno - 1613338 - JOSUE CARINHANHA CALDAS SANTOS
Presidente - 1366289 - THIAGO MENDONCA DE AQUINO