Banca de QUALIFICAÇÃO: THAMILLA MARIA SILVA MACIEL

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : THAMILLA MARIA SILVA MACIEL
DATE: 05/11/2021
TIME: 14:00
LOCAL: Google Meet
TITLE:

Mapping interactions between biologically active compounds with macromolecules and determining species of clinical interest: from  biophysical studies to development of fluorogenic probes

KEY WORDS:

interaction; julolidine; urease; phosphatase; thiol.

PAGES: 80
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUMMARY:

Biophysical studies were carried out in this work with enzymes and small molecules (ligands or probes). Initially, the interaction  between julolidine and amino acid derivatives with urease was evaluated, investigating their potential to inhibit the urease enzyme  in vitro and soil tests. The inhibitory action of the compounds was evaluated against other known inhibitors: hydroxyurea (HU),  thiourea (TU), and omeprazole (OM). The second part of the work to be developed consists of evaluating the efficiency of off-on  latent fluorimetric probes for evaluating species of clinical interest such as acid phosphatase and aminothiols (cysteine,  homocysteine, and glutathione). All procedures will be optimized by simulating physiological conditions and validated against real  samples and reference tests.

BANKING MEMBERS:
Externo à Instituição - JÚLIO SANTOS REBOUÇAS - UFPB
Externo à Instituição - CLEITON MOREIRA DA SILVA - UFMG
Interna - 1869296 - CINTYA D'ANGELES DO ESPIRITO SANTO BARBOSA
Presidente - 1613338 - JOSUE CARINHANHA CALDAS SANTOS