Banca de DEFESA: PAULO RICARDO DOS SANTOS CORREIA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : PAULO RICARDO DOS SANTOS CORREIA
DATE: 28/03/2022
TIME: 09:00
LOCAL: Google Meet
TITLE:

SYNTHESIS, BIOLOGICAL EVALUATION AND IN SILICO STUDIES OF MORITA-BAYLIS-HILLMAN ADDUCTS AGAINST
AEDES AEGYPTI

KEY WORDS:

Morita-Baylis-Hillman; in sílico; Larvicida; Aedes aegypti.

PAGES: 145
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Orgânica
SUMMARY:

Currently, pathogens that have adapted to the changes imposed by nature continue to cause
extensive socioeconomic damage and, especially, to human health. One example is the
Neglected Tropical Diseases caused by viruses, such as Dengue, Zika, and Chikungunya. These
arboviruses, in turn, emerge from zoonotic cycles, mostly transmitted by the arthropod Aedes
aegypti, where for Zika and Chikungunya no vaccine is available yet. Although there is a vaccine
for some serotypes of Dengue, the high expansion of the vector has caused increasing levels of
this disease in epidemic cycles every 3 to 5 years. Therefore, this work aimed to contribute to the
planning and development of molecules with potential biological action against the vector Aedes
aegypti through the Morita-Baylis-Hillman (MBH) reaction methodology and in silico studies to
understand the possible mode of action of such compounds. Thus, the results of the synthesis
were presented satisfactory yields, without the compounds were later submitted to larvicidal
evaluation, together with some MBH compounds made available through a partnership with an
external research group. Among these, 3 showed promising activity, especially methyl 2-([1,1'-
biphenyl]-4-yl(hydroxy)methyl)acrylate (3k). Furthermore, molecular docking studies were
conducted with the enzyme AaAChE, the main biological target in veto control, and other possible
biological targets, suggesting a possible multiple action. However, morphological analyses
suggest probable damage in organs in the thorax region responsible for the synthesis of the
peritrophic membrane, an essential component of the insect defense system. Thus, a
degenerative response was observed in the epithelial tissue in the abdomen region of the larva. In
summary, it is evident that MBH adducts are a promising class of compounds in the population
control of Aedes aegypti.

BANKING MEMBERS:
Presidente - 2089941 - DIMAS JOSE DA PAZ LIMA
Externo ao Programa - 1820228 - RICARDO SILVA PORTO
Interno - 1366289 - THIAGO MENDONCA DE AQUINO
Externo à Instituição - Verônica Diniz da Silva - UFAL