Banca de QUALIFICAÇÃO: MESSIAS DE OLIVEIRA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : MESSIAS DE OLIVEIRA SILVA
DATE: 19/09/2022
TIME: 09:00
LOCAL: SALA DE PÓ-GRADUAÇÃO PPGQB
TITLE:

EVALUATION OF THE ANTIGLYCANT, ANTIOXIDANT AND PHOTOPROTECTIVE POTENTIAL OF ETHANOLIC EXTRACTS FROM DIFFERENT PARTS OF THE JENIPAPO (GENIPA AMERICANA L.)

KEY WORDS:

genipap; oxidative stress; carbonyl stress; glycation;

PAGES: 80
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUMMARY:

A growing body of evidence has revealed the pathogenic role of reactive species and non-enzymatic glycation. Of biomolecules in the development and progression of various diseases, including diabetes, chronic renal failure, neurodegenerative and cardiovascular diseases. Chronic exposure to the sun, combined with a lack of sun protection, leads to formation of reactive species and represents one of the biggest risks for the premature aging of the skin and even the cancer development. The present work aimed to evaluate the antiglycating, antioxidant and photoprotective potential of ethanolic extracts from different parts of the genipap. The antioxidant potential was evaluated by the DPPH• assays, FRAP, O2•˗ and HOCl, the Antiglycant potential was evaluated in the BSA/glucose+fructose and Hemoglobin/glucose+fructose, alterations in the Soret band and hemoglobin fibrillation were also evaluated. You partial results showed that the ethanol extract of the pulp did not reduce the viability of HTR-8SV/neo cells up to a concentration of 300 μg mL-1 , showed antioxidant activity in the methods used, showed protection changes in Soret's band and formation of amyloid fibrils of glycated hemoglobin for the using BSA, the extract showed fluorescence in the region of AGEs formation, making it impossible to determine the IC50, for the analysis of cell viability, the extract did not reduce cell viability and presented a photoprotective effect with FPS > 6.

 

BANKING MEMBERS:
Externa à Instituição - IARA BARROS VALENTIM - IFAL
Presidente - 1006306 - JADRIANE DE ALMEIDA XAVIER
Interno - 1613338 - JOSUE CARINHANHA CALDAS SANTOS
Interna - 2120103 - MARILIA OLIVEIRA FONSECA GOULART
Externa ao Programa - 1320545 - THAISSA LUCIO SILVA