Banca de QUALIFICAÇÃO: JÉSSICA ALVES NUNES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : JÉSSICA ALVES NUNES
DATE: 10/02/2023
TIME: 14:00
LOCAL: RMN do Instituto de Química da UFAL - NAPRMN
TITLE:

Rational design of new coumarins as potential cysteine protease inhibitors from Trypanosoma cruzi and Trypanosoma brucei

KEY WORDS:

Chagas disease; Human African trypanosomiasis; Cruzain; Rhodesain; Rational drug design.

PAGES: 52
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUMMARY:

Chagas disease and Human African Trypanosomiasis are caused by Trypanosoma cruzi and T. brucei, respectively. Cruzain (CRZ) from T. cruzi and cathepsin L-like from T. brucei (TbrCATL) are cysteine proteases considered promising targets for the development of new compounds with trypanocidal activity, since they play vital roles in these parasites. Coumarin derivatives have been reported as promising trypanocidal agents. In this sense, this study aims to synthesize rationally designed coumarin-derived compounds targeting such cysteine proteases from T. cruzi and T. brucei protozoa. Therefore, to discover potential inhibitors of such targets, the rational design of compounds based on molecular docking studies was applied. Subsequently, the biological evaluation of the derivatives and in silico studies of the most promising compounds will be carried out. Finally, it is expected, at the end of this work, to produce potentially active molecules against the T. cruzi and T. brucei parasites, through enzymatic inhibition.

BANKING MEMBERS:
Presidente - 3182336 - EDEILDO FERREIRA DA SILVA JUNIOR
Interno(a) - 1369387 - JOAO XAVIER DE ARAUJO JUNIOR
Externo(a) à Instituição - PEDRO GREGORIO VIEIRA AQUINO
Externo(a) ao Programa - 1461121 - SILVIA HELENA CARDOSO
Interno(a) - 1366289 - THIAGO MENDONCA DE AQUINO
Externo(a) ao Programa - 1488396 - TICIANO GOMES DO NASCIMENTO