Banca de QUALIFICAÇÃO: ADRIELLE FIRMINO DA SILVA NUNES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ADRIELLE FIRMINO DA SILVA NUNES
DATE: 13/02/2023
TIME: 09:00
LOCAL: Google Meet
TITLE:

Synthesis of p-chloro-cinnamamide derivatives: Discovery of new larvicides against Ae. aegypti through
rational planning

KEY WORDS:

Aedes aegypti, cinnamamides, in silico studies, organic synthesis.

PAGES: 53
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUMMARY:

The Ae. aegypti is a vector that has caused great concern in society in recent years, due to the spread of arbovirus epidemics caused by it. Currently, its population control has been occurring through the application of insecticides, which, however, have not been effective due to generalized resistance among populations of this vector. In view of this, the present study aimed at the in silico design and synthesis of pchloro-cinnamamide derivatives. For this approach, the target fishing method was used, followed by a virtual screening. The results were validated and showed that this chemotherapeutic can be a good candidate for larvicide, as it has a structure that is within the standards set for a selective and environmentally safe insecticide. In addition, it showed pronounced affinity for acetylcholinesterase, epoxide hydrolase and juvenile hormone binding protein present in the larva. Cinnamamides were selected, synthesized and characterized, obtaining yields between 45-60%. In short, molecules were planned and synthesized, the results in question suggest good candidates for larvicide, however experimental studies must be carried out to prove the accuracy of in silico studies.

BANKING MEMBERS:
Externo(a) ao Programa - 776.707.014-04 - CENIRA MONTEIRO DE CARVALHO - UFAL
Interno(a) - 2089941 - DIMAS JOSE DA PAZ LIMA
Interno(a) - 1006306 - JADRIANE DE ALMEIDA XAVIER
Externo(a) à Instituição - Verônica Diniz da Silva