Banca de DEFESA: MESSIAS DE OLIVEIRA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MESSIAS DE OLIVEIRA SILVA
DATE: 20/03/2023
TIME: 14:00
LOCAL: SALA DE PÓS-GRADUAÇÃO - PPGQB
TITLE:

EVALUATION OF THE ANTIGLYCANT, ANTIOXIDANT AND PHOTOPROTECTIVE POTENTIAL OF ETHANOLIC EXTRACTS FROM DIFFERENT PARTS OF THE JENIPAPO (GENIPA AMERICANA L.)

KEY WORDS:

genipap; oxidative stress; carbonyl stress; glycation;

PAGES: 100
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUMMARY:

A growing body of evidence has revealed the pathogenic role of reactive species and non-glycation enzymatic action of biomolecules in the development and progression of various diseases, including diabetes, chronic kidney disease, neurodegenerative and cardiovascular diseases. Chronic exposure to the sun, combined with a lack of sun protection, leads to the formation of reactive species and represents one of the greatest risks for aging premature aging of the skin and even the development of cancer. The present work aimed to evaluate the antiglicante potential, antioxidant and photoprotective properties of ethanolic extracts from different parts of genipap. The antioxidant potential was evaluated by DPPH tests• , FRAP, O2 •˗ and HOCl, the Antiglycant potential was evaluated in the systems BSA/glucose+fructose and Hemoglobin/glucose+fructose, alterations in the Soret band and fibrillation were also evaluated of hemoglobin, the photoprotective potential was evaluated by the Mansur method. The results showed activity antioxidant in the methods used for the extracts, the pulp extract showed low protection against changes in Soret's band and formation of amyloid fibrils from hemoglobin subjected to glycation, for the system using BSA all extracts showed fluorescence in the region of AGE formation making it impossible to determine IC50, for the analysis of cell viability, the extract did not reduce cell viability and showed an effect sunscreen with SPF > 6 both for extracts and for formulations containing only extracts and formulations incorporated with benzophenone-3.

BANKING MEMBERS:
Interno(a) - 2089586 - FRANCIS SOARES GOMES
Externo(a) à Instituição - IARA BARROS VALENTIM - IFAL
Presidente - 1006306 - JADRIANE DE ALMEIDA XAVIER
Interno(a) - 1613338 - JOSUE CARINHANHA CALDAS SANTOS
Interno(a) - 2120103 - MARILIA OLIVEIRA FONSECA GOULART