Banca de DEFESA: RODGER MARCEL LIMA ROCHA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : RODGER MARCEL LIMA ROCHA
DATE: 28/03/2022
TIME: 09:00
LOCAL: por videoconferência
TITLE:

PERINEURAL INVASION IN EPIDERMOID CARCINOMA OF THE HEAD AND NECK: IMPACT OF GENES RELATED TO CIRCADIAN RHYTHM

KEY WORDS:

Proliferation; Schwann; Tumor progression; Metastasis.

PAGES: 61
BIG AREA: Ciências Biológicas
AREA: Bioquímica
SUMMARY:

During the processes of tumor formation and progression there is the involvement of the action of cells

that create a favorable microenvironment for cancer development. Among the mechanisms involved in

these events are circadian rhythm alterations and perineural invasion. Both events have been described,

separately, as active in tumor aggressiveness. It is important to identify events related to circadian

rhythm alterations that are associated with cancer that may directly impact the invasion of this tissue

into the peripheral nervous system. The aim of this study was to evaluate perineural invasion in head

and neck cancer, associating it with genes related to the peripheral nervous system and circadian rhythm.

The data showed that the circadian rhythm and axon guidance pathways were deregulated in head and

neck squamous cell carcinoma with positive perineural invasion. Differential expression analyses identified

that genes associated with Schwann cell response in injured nerves that are positively regulated

activate the circadian rhythm pathway. Negative correlation was identified between expression and

methylation of PER3 and RORC genes when analyzed separately in both tumor groups. Positive correlations

between expression of PER2 and RORC, as well as of RORC with MPZ, S100A8 and NUF2

genes were identified only in the groups of patients who did not present perineural invasion. Circadian

rhythm genes are dysregulated in neoplastic tissues, with increased expression of oncogenes and decreased

expression of tumor suppressors. Increased expression of mTOR protein was identified in patients

presenting with perineural invasion. The data suggest that dedifferentiation and proliferation of

Schwann cells may be associated with downregulation of circadian rhythm genes; consequently,

Schwann cells produce different factors that participate in various processes of tumor progression and

invasion of adjacent tissues, including activation of the mTOR pathway. These processes may also be

involved in tumor invasion into the perineural tissue in head and neck cancer.

BANKING MEMBERS:
Externa ao Programa - 2363781 - AMANDA KARINE BARROS FERREIRA RODRIGUES
Presidente - 2361727 - CARLOS ALBERTO DE CARVALHO FRAGA
Interna - 2269479 - CAROLINNE DE SALES MARQUES
Externa ao Programa - 2390962 - JUSSARA ALMEIDA DE OLIVEIRA BAGGIO