Banca de QUALIFICAÇÃO: TAYNA FERREIRA DE LIMA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : TAYNA FERREIRA DE LIMA
DATE: 06/03/2024
TIME: 08:30
LOCAL: Sala 204 do PPGCF/ICF-UFAL
TITLE:

Synthesis and characterization of ferulic acid in polymeric matrices containing Eudragit and Polycaprolactone (PCL), analyzing its functions and properties and antioxidant activity and benefits for use of this medicine

KEY WORDS:

Ferulic acid, antioxidant, collagen, phenols, polymers

PAGES: 28
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Studies indicate that phenolic acids are excellent natural antioxidants due to the presence of phenolic hydroxyl groups in their structures capable of effectively eliminating free radicals, in addition to having bactericidal properties due to their ability to interact with the cell wall. Ferulic acid (FA) is a phenolic acid that is the subject of this study. Its advantage is that it aids in the formation of collagen, a fibrous protein with high biodegradability and the ability to form collagen films due to its unique triple helix structure and high mechanical resistance. Addition to manifesting antidiabetic, antitumor and lung protection properties, improving neurodegenerative disorders in addition to combating other pathologies and having low toxicity. Ferulic acid has some disadvantages, such as low bioavailability, rapid absorption and metabolic elimination via oral administration. Its classification in the Biopharmaceutical Classification System (SCB) is class II, presenting os its main characteristics an active ingredient with low solubility and high permeability, resulting in an ineffective profile in the gastrointestinal tract through conventional delivery systems. As there is no contraindication to its use with a topical effect, the objective of the project is to synthesize a polymeric substance containing ferulic acid for use in pharmaceutical inputs and products due to its antioxidant, anti-inflammatory and collagen cross-linking functions. Scanning electron microscopy, Fourier transform infrared - (FTIR), free radical method - DPPH, UV dosing, particle determination and polydispersity and spectrophotometry - UV-VIS will be used for characterization, seeking to evaluate the benefits of AF in a system with PCL and Eudragit. Preliminary results indicate good antioxidant activity using DPPH, corroborating the literature, good transformation of crystals into amorphous agglomerates when incorporated into the PCL, Eudragit system or in conjunction with both through the SEM technique, pointing to ferulic acid as a promising low-cost active ingredient for topical use.  

COMMITTEE MEMBERS:
Interno(a) - 1527220 - CAMILA BRAGA DORNELAS
Presidente - 1885138 - ISABEL CRISTINA CELERINO DE MORAES PORTO
Externo(a) ao Programa - 3495043 - NATANAEL BARBOSA DOS SANTOS - UFAL