Banca de QUALIFICAÇÃO: SUZANNE PINHEIRO VIEIRA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : SUZANNE PINHEIRO VIEIRA
DATE: 17/02/2022
TIME: 14:00
LOCAL: Vìdeoconferência
TITLE:

Cardiovascular Effects induced by Anonnacea: A Systematic Review of the Literature

KEY WORDS:

Anonnacea; Antihypertensive; vasorelaxant; hypotension; bradycardic; cardiotonic; cardioprotection; antiarhythimic e cardiovascular effects

PAGES: 57
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUBÁREA: Farmacognosia
SUMMARY:

Cardiovascular diseases (CVDs) are the main causes of mortality worldwide and generate a significant financial impact on the health system. Among the CVDs, the most prevalent in the public health scenario is Systemic Arterial Hypertension (SAH), which presents a multifactorial clinical state, defined by the sustained increase in blood pressure. The asymptomatic character of SAH defies early diagnosis and its pharmacological treatment is difficult to adhere to due to drug interactions, due to polypharmacy, the cost of drugs and lack of education. Given these circumstances, it is attractive to implement new resources that help to overcome the lack of drug acceptance among patients. Thus, medicinal plants are an important alternative in the treatment of CVDs and the genus Annona has shown hypotensive and vasodilating properties in teas and leaves of some species. Therefore, the current work aimed to carry out a systematic review of the literature on the cardiovascular effects of plant species belonging to the Annonaceae family, emphasizing their implications for arterial hypertension and for the development of this study, the search and analysis of information by bibliographic means was carried out. based on scientific articles. The selected databases were: Scielo, Web of Science, Scopus, Lilacs, Pubmed, Science direct and Medline. The research strategies to obtain information were using the following keywords: "Anonnacea" associated with the name of each species belonging to the family, followed by the terms: "Antihypertensive", "vasorelaxant", "hypotension", "bradycardic", " cardiotonic”, “cardioprotection”, “antiarhythimic” and “cardiovascular effects”. Furthermore, there was no language or time restriction. 9.6% of the genera and 0.72% of the plant species presented studies on pharmacological effects on the cardiovascular system (CVS). The genera Annona and Xylopia stood out. 68.42% evaluated the pharmacological effects of only substances isolated from different species of Annonaceae, 26.32% evaluated only extracts, while 5.3% evaluated essential oil. Regarding the part of the plant used to obtain the extracts/fractions/isolated substances: 42.86% of the studies used the leaves; 28.57% stem bark; 21.43% the roots; 7.14% the seeds; and 7.14% the fruits. Regarding the type of experimental animal: 88.88% of the studies used rats, of which 87.5% were Wistar and 12.5% Sprague–Dawley; 11.11% used mice; and 5.55% used rabbit, frog or guinea pig. Regarding the type of experimental approach: 27.77% of the studies carried out an in vitro and in vivo approach; 50% in vitro only; and 22.22% only in vivo. It is concluded that the Annonaceae family has phytochemical substances with great pharmacological properties in the SCV, and the vasorelaxant and hypotensive effects were mentioned several times, revealing in a uniform way that the main mechanism of action observed was the induction of changes in intracellular calcium levels. . Therefore, this family proved to be a great therapeutic potential to be studied for the treatment of diseases that affect the SCV.

BANKING MEMBERS:
Interna - 1547952 - EURICA ADELIA NOGUEIRA RIBEIRO
Interna - 1331191 - SABRINA JOANY FELIZARDO NEVES
Interno - 1488396 - TICIANO GOMES DO NASCIMENTO