Banca de DEFESA: ANTONY ERNESTO DOS SANTOS SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ANTONY ERNESTO DOS SANTOS SILVA
DATE: 27/06/2022
TIME: 14:00
LOCAL: Vìdeoconferência - Google Meet
TITLE:

Synthesis of aminoquinolinic compounds with potential antimalarial activity

KEY WORDS:

Malaria; Antimalarials; Aminoquinolines; Catalytic Hydrogenation; Synthesis.

PAGES: 102
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUBÁREA: Análise e Controle de Medicamentos
SUMMARY:

Malaria is considered one of the most serious parasitic diseases of this class, often being fatal and with a high rate of transmission in countries with tropical climates. In 2020 alone, it is estimated that there were 241 million cases and 627,000 deaths from the disease. Such alarming numbers point to a deficiency in antimalarial treatment triggered, basically, by the resistance of the parasites that cause malaria, especially by plasmodium falciparum against chloroquine, making it necessary to develop new antimalarial agents active against these resistant strains. Therefore, this work proposed two strategies in order to obtain compounds with potential antimalarial action from a base aminoquinoline compound that has already shown good activity: i) modification of the side chain that contains a CC triple bond for the olefinic and saturated forms; and ii) alteration of the amino group at the end of the side chain by heterocycles. Thus, the active base compound, N1-(7-chloroquinolin-4-yl)-N4,N4-diethyl-but-2-yne-1,4-diamine (DAQ), underwent catalytic hydrogenation, leading to the generation of compounds (E)-N1-(7-chloroquinolin-4-yl)-N4,N4-diethyl-but-2-ene-1,4-diamine (DAQH2) and N1-(7-chloroquinolin-4-yl)-N4,N4-diethyl-butane-1,4-diamine (DAQH4) and as a by-product the compound N1-(quinolin-4-yl)-N4,N4-diethyl-butane-1,4-diamine (DAQH4(-Cl)) . The yield and proportion between these compounds formed is dependent on the time of the hydrogenation reaction. In addition, the novel compounds N-(4-(pyrrolidin-1-yl)-but-2-yn-1-yl)-7-chloro-quinolin-4-amine (DAQP), N-(4-(morpholino) )-but-2-yn-1-yl)-7-chloro-quinolin-4-amine (DAQM) and N-(4-(piperidin-1-yl)-but-2-yn-1-yl)- 7-Chloro-quinolin-4-amine (DAQPP) were obtained in yields of 35%, 24% and 25% respectively, from Mannich reactions with N-(prop-2-ynyl)-7-chloro-quinolin- 4-amine (PCQ) and heterocycle compounds. These compounds were characterized by techniques such as Nuclear Magnetic Resonance (NMR), Infrared Spectroscopy (FT-IR), Mass Spectrometry (GC-MS), and Simultaneous Thermal Analysis (DSC-TGA). All compounds obtained in this work were sent for biological analysis to determine their toxicity and antimalarial action, especially against chloroquine-resistant strains.

BANKING MEMBERS:
Externa ao Programa - 1820117 - ISIS MARTINS FIGUEIREDO
Interno - 1369387 - JOAO XAVIER DE ARAUJO JUNIOR
Interno - 1348288 - MARIO ROBERTO MENEGHETTI