Banca de QUALIFICAÇÃO: LAISA CAROLINA GOMES DE BULHOES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : LAISA CAROLINA GOMES DE BULHOES
DATE: 03/03/2023
TIME: 13:00
LOCAL: Sala 205 do PPGCF
TITLE:

Development and characterization of alginate globules loaded with essential oil of Syzygium aromaticum (clove) obtained by the ionic gelation technique and evaluation of antioxidant activity

KEY WORDS:

Syzygium aromaticum, antioxidant activity, ionic gelation

PAGES: 50
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Essential oils are complex substances that have in their composition several constituents that give these oils biological activities. The clove (Syzygium aromaticum) is an arboreal plant of the Myrtaceae family that has been used in medicine since ancient times, possessing an antioxidant, anesthetic, insecticidal and antimicrobial activity. The encapsulation technique by ionic gelation consists of producing spheres by electrostatic interactions between ionic polymers and ions with different charges, in order to form a three-dimensional network, for the entrapment of the active compound. In this context, the objective of this work was to develop alginate globules loaded with clove essential oil through the ionic gelation technique, identify and quantify the main marker of clove essential oil, quantify the total phenols and evaluate the antioxidant potential and thermally characterize the alginate globules carried with clove essential oil. The globules were obtained by the ionic gelation technique. Essential oil and globules were evaluated for antioxidant activity by DPPH methods. Quantification of total phenols was performed using the Folin-Ciocalteau method. Identification and quantification of the main oil marker were performed by GC-MS. The thermogravimetric stabilities of the globules were evaluated by TGA and DSC. Contents of 1190.66, 714.84 and 433.43 mg EAG g-1 of total phenolic compounds were found in the essential oil and globules of 1% and 2% alginate, respectively. The DPPH antioxidant method showed high activities where in the EO the percentage was from 28.16% to 80.27% and in the 1% alginate globules 12.90% to 59.36%, 2% alginate globules 11, 19% to 31.79%. Eugenol was the major compound in the essential oil with a content of 83.73. The encapsulation efficiency was 7.12% in the 1% alginate formulation and 10.22% in the 2% alginate formulation. The globules presented a translucent appearance, while those with the oil presented an opaque color, closer to white. Thermal analysis showed good stability for the globules. The ionic gelation process was successful, providing greater thermal stability to the clove essential oil, maintaining its biological properties.

 

BANKING MEMBERS:
Interno(a) - 1553302 - IRINALDO DINIZ BASILIO JUNIOR
Interno(a) - 1488396 - TICIANO GOMES DO NASCIMENTO
Externo(a) ao Programa - 4425539 - JOSE RUI MACHADO REYS