Banca de QUALIFICAÇÃO: ERIKA ELITA ARAUJO LESSA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ERIKA ELITA ARAUJO LESSA
DATE: 21/03/2023
TIME: 10:00
LOCAL: Sala 205 do PPGCF
TITLE:

Analysis of problems related to sleep and medication adherence in patients with chronic kidney disease: perspective on the importance of pharmaceutical care

KEY WORDS:

Chronic Kidney Disease. Sleep disorder. Sleep-wake cycle. Circadian Rhythm. Chronotype. Medication Adherence.

PAGES: 60
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Chronic kidney disease (CKD) is underestimated in Brazil and the main risk factors such as hypertension, obesity, smoking, diabetes and cardiovascular diseases can develop asymptomatically in the long term and progress to the advanced stage of CKD. The hemodialysis procedure requires the patient to stay at least three times a week for 3 to 4 hours. Dialysis schedules can interfere with sleep and cause irregular sleep schedules in the long term, which, in turn, indicates changes in the sleep-wake cycle and in the circadian rhythm that can alter melatonin levels and decrease its nocturnal release, leading to disorders of sleep and increased risk of cardiovascular complications and mortality. In the literature, the prevalence of sleep disorders and poor medication adherence in patients with CKD are well evidenced, but there are few studies on whether sleep-related problems are associated with poor medication adherence. In addition, until the time of the study, there were no reports in the literature on the identification of circadian chronotype and occurrence of social jetlag in hemodialysis patients. Therefore, the study aims to analyze the problems related to sleep, circadian preference behavior and medication adherence in hemodialysis patients. A cross-sectional study was carried out with 108 patients with CKD undergoing hemodialysis treatment in three hospitals in Maceió from June to November 2022. Data collection was performed through interviews with the patient using the following questionnaires validated in the literature: Pittsburgh Sleep Quality Index – PSQI, EPWORTH Daytime Sleepiness Scale, Chalder Fatigue Scale, Morisky Therapeutic Adherence Scale (MMAS-8), Obstructive Sleep Apnea Risk Factor Questionnaire - STOP-Bang, identification of circadian chronotypes Morningness Eveningness Questionnaire - MEQ, evaluation of the occurrence of social jetlag and sleep duration in the Munich Chronotype Questionnaire - MCQT. Questions about health conditions, lifestyle, sociodemographic data and continuous use medication were also addressed. The main results obtained, the patients had morning circadian preference (56.5%), the majority resided in the municipalities of Alagoas (62%) and traveled by car to Maceió, underwent hemodialysis for more than 3 years (67.6% ). Among concomitant diseases, hypertension was the most frequent (60.2%), patients used cell phones before going to bed (61.1%), reporting that they used them for more than 2 hours (27.8%). Short sleep duration was observed in patients, 62.9% had a sleep duration < 6 hours, poor sleep quality (57.4%), high-risk prevalence of obstructive sleep apnea syndrome (64.8% ), low adherence to medication (72.2%) and occurrence of social jetlag in patients was evidenced over 1 hour (56.5%). Therefore, interventions for sleep disorders and medication adherence are necessary in the multidisciplinary team. The results also indicate the importance of the pharmacist's presence in the hemodialysis unit in carrying out pharmaceutical care.

BANKING MEMBERS:
Interno(a) - 1640070 - ELIANE APARECIDA CAMPESATTO
Interno(a) - 1547952 - EURICA ADELIA NOGUEIRA RIBEIRO
Externo(a) ao Programa - 4425539 - JOSE RUI MACHADO REYS