Banca de DEFESA: SAULO VITOR SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : SAULO VITOR SILVA
DATE: 29/03/2023
TIME: 15:00
LOCAL: Sala 204 do PPGCF
TITLE:

COMPATIBILITY AND THERMAL STABILITY STUDY OF RED PROPOLIS ASSOCIATED WITH DIFFERENT EXCIPIENTS IN OBTAINING POLYMERIC MEMBRANES

KEY WORDS:

Red propolis, Film, Thermal Analysis, Antioxidant activity

PAGES: 88
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Red propolis from Alagoas is a sticky resin made from a complex mixture of biologically active substances with great biotechnological potential. Various studies have shown that red propolis extracts have a wide variety of biological activities as an antioxidant. Drug-excipient compatibility testing is one of the most fundamental phases in the pre-formulation research process. Given the above, this research aims to evaluate compatibility and thermal stability of red propolis associated with different excipients in obtaining polymeric membranes. The ethanolic extract of red propolis by maceration. Assays were carried out to quantify the content of phenolic compounds, using the Folin-Ciocalteu reagent method, and flavonoids, using the aluminum chloride method of the EEPV. The investigation of the antioxidant activity of EEPV was carried out using the DPPH method. Synthetic membranes were prepared using the solvent evaporation method. And the physical-chemical properties of thermal stability of membranes, components, and binary mixtures were analyzed by Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetric Analysis (DSC). It was estimated that the content of total phenolic compounds was 208.0 mg EAG.g-1, and the total flavonoid content was 45.3 mg EAG.g-1. The analysis of the antioxidant activities of EEPV by the DPPH method varied between 59.36% and 88.31%. The thermal profile obtained by the EEPV TGA showed 4 thermal degradation events, none of which were superimposed. The second event (onset: 82.01 °C, endset: 135.29 °C and mass loss of 12.83%). Thermogravimetric thermal analyzes (TGA) showed sodium benzoate as the most stable excipient. Second curve (onset: 514.77 °C, endset: 562.11 °C and mass loss of 44.79%). Propylene glycol was the least stable excipient. Its second thermal event (onset: 117.43 °C, endset: 147.35 °C and 82.57% mass loss). Membranes and binary mixtures were successfully obtained and presented a uniform appearance. The MX1 membrane presented 7 thermal degradation events, with the 1st overlapping with the 2nd, the 3rd with the 4th, and the 6th with the 7th. The second thermal event (onset: 54.75 °C, endset: 104.48 °C and mass loss of 15.88%). The EEPV decomposition curve by DSC showed two thermal events. The first transition process was endothermic (onset: 153.32 °C; endset: 364.35 °C; peak: 346.48 °C; enthalpy: -152.62 J/g). The EEPV + sodium benzoate binary mixture curve showed 6 thermal events. The first event was endothermic (onset: 35.12 °C; endset: 79.85 °C; peak: 61.38 °C; enthalpy: -36.04 J/g). The MX1 decomposition curve by DSC showed 4 transition processes. The first and third being endothermic, and the second and fourth exothermic. The first (onset: 126.49 °C, endset at 136.09, and enthalpy: -21.53 J/g). Thus, the red propolis ethanolic extract showed good thermal stability. And, among the excipients, sodium benzoate was the most thermally stable. In contrast, propylene glycol was the excipient with the lowest thermal stability. And all excipients were compatible with red propolis ethanolic extract. All membranes were successfully obtained, however thermogravimetric analysis (TGA) determined that MX1 has better thermal stability.

BANKING MEMBERS:
Interno(a) - 1553302 - IRINALDO DINIZ BASILIO JUNIOR
Externo(a) ao Programa - 4425539 - JOSE RUI MACHADO REYS
Interno(a) - 1488396 - TICIANO GOMES DO NASCIMENTO