Banca de DEFESA: FABIO SOUZA MOURA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : FABIO SOUZA MOURA
DATE: 29/08/2023
TIME: 09:00
LOCAL: Instituto de Ciências Farmacêuticas/UFAL
TITLE:

Technological Prospecting and Evaluation of the Leishmanicidal Potential of Pyroligneous Extracts.

KEY WORDS:

pyroligneous extracts, leishmanicidal, technological prospectio

PAGES: 94
BIG AREA: Ciências Biológicas
AREA: Farmacologia
SUBÁREA: Farmacologia Bioquímica e Molecular
SUMMARY:

Leishmaniasis is still one of the most neglected diseases in the world, affecting millions of people mainly in poor and underdeveloped countries. In Brazil, leishmaniasis is a public health problem due to its ease of propagation and ability to cause epidemics. Given this scenario, pyroligneous extracts have drawn the attention of many researchers, given that their processing can contribute to the development of chemical entities with pharmacological potential. In the Technological Prospecting carried out, it was possible to observe the
formulation of innovations using pyroligneous extracts for therapeutic purposes and the application of these extracts in the treatment of pathologies such as cancer. The exercise of technological prospection is fundamental to guide the development of new technologies. In the experimental study, seven extracts from plants typical of the Brazilian flora were tested. All extracts showed leishmanicidal effects for the evolutionary form of promastigote amazonensis (100% ± 0.00) with IC 50 ranging from 0.01% (Mimosa tenuiflora) to 0.26%
(Eucalyptus), however, they showed cytotoxic effects in the order of 95.13% (Pennisetum purpureum) for macrophages of the J774.A1 strain in the MTT assay. The results obtained in the pharmacological tests associated with those presented in the Technological Prospecting indicate that studies need to be implemented in order to standardize an extraction method, thus favoring the obtainment of compounds with pharmacological
properties.

BANKING MEMBERS:
Presidente - 2272670 - ALINE CAVALCANTI DE QUEIROZ
Interno(a) - 1488396 - TICIANO GOMES DO NASCIMENTO
Externo(a) à Instituição - CAMILA CALADO DE VASCONCELOS - CESMAC
Externo(a) à Instituição - AMANDA EVELYN DA SILVA