Banca de DEFESA: CLARA ANDREZZA CRISOSTOMO BEZERRA COSTA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : CLARA ANDREZZA CRISOSTOMO BEZERRA COSTA
DATE: 21/08/2023
TIME: 09:00
LOCAL: Sala 205 do PPGCF
TITLE:

Determination of Thermal Stability and Microstructure Degradation of Acrylamides LQM330, 333, 336 and 338 Active Against the CHIKV Virus

KEY WORDS:

Thermalanalysis; DSC; Drugs; Medicines; TG.

PAGES: 69
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

The characterization of solids for the development of pharmaceuticals and medicines is essential to ensure the processing, transport, and storage of final products. Acrylamides are organic substances, some of which are active against Dengue (DENV) and Zika (ZIKV) viruses, showing significant biological action and low toxicity in human cells. In recent decades, it has been noted a growing number of cases of pests infection by chikungunya (CHIKV), this disease, is quite neglected, with the absence of vaccination and treatments. The study and characterization of active molecules are of great importance for therapeutic alternatives still unknown or little explored. Thus, characterization by thermal analysis and complementary analytical techniques for solids are essential tools for the development of new drugs, as they provide data on the thermal behavior and chemical structure of materials. The work aimed to determine the thermal stability and degradation of the microstructures of acrylamides LQM330, 333, 336, and 338 active against the virus CHIKV. The characterization of the molecules was carried out by thermogravimetry (TG), Differential Scanning Calorimetry (DSC), Spectrophotometry in the Ultraviolet and Visible Region (UV-vis) It in the infrared region with Fourier transform (IRTF), Gas chromatography coupled to mass spectrometry (GC/IN), High-Performance Liquid Chromatography (HPLC) It is Scanning electron microscopy (SEM). The obtained results showed that LQM330 molecules, 333, 336, and 338 showed GC/MS and HPLC purities in the range of 92.50 to 99.55 and from 99.81 to 98.88%. The TG curves demonstrated that the molecules are stable at indifferent heating rates (10,20,30,40, and 50 ºC/min). Thermal decomposition profiles are very similar among acrylamides, with the presence of an endothermic event, except for sample LQM330 that presented exothermic events by DSC, this technique also provided data on the purity of the molecules in the range of 96.31% to 98.82%. The UV-vis spectra evidenced that the speak maximums of absorption for around 220 to 335 nm. Already the IR spectra TF demonstrated the presence of C=O stretching and NH stretching. The samples showed morphology heterogeneous, brittle with clusters in general, except for samples at T600 C that expose Forms of whole and homogeneous cubes, results verified by SEM. Soon, the good thermal stability of the molecules confirmed that they are promising candidates for the development of future drugs against the virus CHIKV and, that characterization by thermal analysis and complementary analytical techniques provided specific and crucial data for the advancement of the pharmaceutical sector.

 

BANKING MEMBERS:
Externo(a) à Instituição - ALAN JOHN DUARTE DE FREITAS - IFAL
Interno(a) - 3182336 - EDEILDO FERREIRA DA SILVA JUNIOR
Externo(a) à Instituição - JOHNNATAN DUARTE DE FREITAS - IFAL
Interno(a) - 1488396 - TICIANO GOMES DO NASCIMENTO