Banca de QUALIFICAÇÃO: RITA MARCIA PACHECO LINS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : RITA MARCIA PACHECO LINS
DATE: 20/09/2021
TIME: 20:00
LOCAL: google meet
TITLE:

Association between suicide risk and plasma levels of Interleukin-6 in patients with Systemic Lupus Erythemitatosus

KEY WORDS:

Suicide; Systemic Lupus Erythemitaesus; Interleukin-6; Depression;

PAGES: 35
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Introduction: Suicidal behaviors constitute a global health burden and lead to the annual death of 1 million people worldwide. Populations with depression and suicide risk have high il-6 levels. Patients with Systemic Lupus Erytheatosus (SLE) have a prevalence of psychiatric manifestations between 10 and 80%. Objective: To investigate the risk of suicide in patients with SLE and the association with plasma levels of the biomarker- Interleukin-6. Material and Methods: Cross-sectional study, convenience sample of women diagnosed with SLE and attended at the Professor Alberto Antunes University Hospital of the Federal University of Alagoas. Data were collected using the assessment instruments: Mini International Neuropsychiatric Interview v.5.0.0, Beck Depression Inventory, Beck Hopelessness Scale, Pittsburgh Sleep Quality Index, Short-Form-36 form and peripheral blood collection for IL-6 biomarker analysis through ELISA through cytokine kits (Biosciences®). The data was transferred to the SPSS program for Windows version 23 (SPSS Inc. Chicago, IL). The Shapiro-Wilk Test was used to assess the normality of the variables, the distribution of the sample was non-normal, the mean scans between the groups were performed by the Mann-Whitney test. For the analysis of the association of dichotomous variables, a Chi-square test was performed and the odds ratio calculation (odds-ratio), 95% confidence interval and statistical significance established in 5% (p<0.05) were generated. Preliminary results: The sample consisted of 45 women, mean age 36.57 (±9.47 years. Of these, 31.1% had Major Depressive Episode (MD) and 53.3% had at least one anxiety disorder. Patients with MDD presented suicide risk 14.5 times higher than non-depressed patients, in addition to worsening sleep quality and greater impairment in quality of life in several domains of the SF-36. Interleukin-6 biomarker analysis has not yet been performed. Conclusion: The prevalence of depression was higher than that described in the general population. The risk of suicide was associated with higher severity of depressive symptoms and hopelessness and worse scores of quality of life and quality of sleep.

BANKING MEMBERS:
Externa à Instituição - SHEILA CAVALCANTE CAETANO - UNIFESP
Interno - 1137473 - CLAUDIO TORRES DE MIRANDA
Interna - 2370894 - MICHELLE JACINTHA CAVALCANTE OLIVEIRA
Presidente - 1728726 - VALFRIDO LEAO DE MELO NETO