Banca de DEFESA: CARLOS ALEXANDRE FERREIRA DE OLIVEIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : CARLOS ALEXANDRE FERREIRA DE OLIVEIRA
DATE: 29/04/2022
TIME: 14:00
LOCAL: Google Meet
TITLE:

INFLAMMATORY RESPONSE AND SARCOPENIA AFTER COVID-19 INFECTION IN OBESE DIABETIC RENAL PATIENTS CHRONIC IN HEMODIALYSIS.

KEY WORDS:

Chronic kidney disease. Diabetes. Obesity. Covid 19.

PAGES: 35
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

INTRODUCTION: Diabetic nephropathy is the main cause that leads diabetic patients to hemodialysis. At this time of pandemic by COVID 19, infection caused by the new coronavirus (SARS- CoV-2), patients with diabetes, especially the obese, are part of the risk group that can evolve with the most severe presentation of the disease. In this group of patients, obese with diabetes and patients with chronic kidney disease, the inflammatory process occurs in an exacerbated manner with the uncontrolled elevation of inflammatory cytokines and may have a fatal outcome. The sarcopenia present in these diabetic, obese and oral patients also appears as a complicating factor of COVID 19, with repercussions still uncertain in the post-infection scenario. OBJECTIVE: To investigate the inflammatory response and sarcopenia after covid-19 infection in participants with chronic kidney disease and overweight/obesity, diabetics, undergoing hemodialysis. MATERIALS AND METHODS: The sample consisted of 32 diabetic patients on hemodialysis (sample calculation from the data of diabetics on dialysis according to a Brazilian survey conducted by the Brazilian Society of Nephrology - SBN, in 2017), of both sexes, assisted by the Integrated Nephrology Center of the University Hospital Professor Alberto Antunes (HUPAA), Hospital Veredas and UNIRIM. The participants were divided into two groups; A: Those with confirmed Infection by Sars-COV-2 and B: Those who did not have Sars-COV-2 infection. Demographic and laboratory data were collected. RESULTS: Group A (mean + standard deviation): n = 12 Age 60.33 + 8.03 years; BMI 31.19+1.89 Kg/m2; Dialysis time 865+689 days; Hematocrit 33.32 +4.84; Hemoglobin 10.72+1.43; Urea 148.82+31.18; Creatinine 8.53+3.04; Ca 8.35+0.49; P 5.89+1.30; Albumin 3.74+0.51; Globulins 2.96+0.52; Ferritin 229+185; PTH 460.55+350.01. Group B is described as well (mean + standard deviation): n = 30; Age 65.55 + 9 years; BMI 30.95+3.24 Kg/m2; Dialysis time 1175+768 days; Hematocrit 33.17 +4.22; Hemoglobin 11.03+1.37; Urea 139+43.91; Creatinine 7.69+2.56; Ca 8.64+0.98; P 5.1+1.82; Albumin 3.79+0.61; Globulins 3.59+1.39; Ferritin 253+197; PTH 207.76+258.31. CONCLUSION: We have not found so far a difference between the markers studied in the groups studied. More analysis is required for effective completion.

BANKING MEMBERS:
Externa ao Programa - 1715527 - ALESSANDRA ABEL BORGES
Interna - 4364569 - FABIANA ANDREA MOURA
Interna - 7530212 - MERCIA LAMENHA MEDEIROS
Presidente - 2370894 - MICHELLE JACINTHA CAVALCANTE OLIVEIRA
Externa à Instituição - RAQUEL FERNANDES VANDERLEI VASCO
Interno - 2154281 - RODRIGO PEIXOTO CAMPOS