Banca de QUALIFICAÇÃO: MARINA DEMAS REZENDE GISCHEWSKI

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : MARINA DEMAS REZENDE GISCHEWSKI
DATE: 22/06/2023
TIME: 09:00
LOCAL: famed
TITLE:

Nutritional profile, frailty and sarcopenia in liver transplant candidates and their association with redox imbalance and pro-inflammatory cytokines

KEY WORDS:

liver transplantation, sarcopenia, fragility, oxidative stress,
inflammation.

PAGES: 35
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

INTRODUCTION: Liver transplantation (HTT) is the treatment of choice for cases
acute or chronic end-stage liver disease, provided that the benefits of
treatment outweigh the risks inherent in the procedure. While the patient is on the list
Waiting, the team should focus on the management of the underlying disease and complications, to
that is in adequate conditions at the time of TxH. In these individuals it is observed
a metabolic change in the primary fuel from glucose to fatty acids and
proteins, combined with a reduction in protein synthesis which also contributes to the
muscle depletion and installation of sarcopenia. Also seen in patients with liver disease, the
frailty manifests as loss of muscle function, beyond dimensions
psychological and social, being amenable to reversal when properly diagnosed.
The presence of these nutritional extremes is directly related to the inflammatory process
related to the underlying mechanism of disease, which is intrinsically linked to stress
oxidative. OBJECTIVE: To identify how nutritional status, frailty and sarcopenia
are associated with the presence of inflammation and oxidative stress in candidates for
liver transplantation. MATERIALS AND METHODS: This is a cross-sectional study,
whose data collection, in progress, began in October 2022, after approval by the
Research Ethics Committee of the Federal University of Alagoas, with a forecast of
end in August 2023, at the pre and post liver transplant outpatient clinic of the Hospital
University Professor Alberto Antunes. Screening tools and
nutritional assessment for cirrhotic RFH-NPT and RFH-GA, screening for
sarcopenia as recommended by the EWGSOP2 and frailty through the

Liver Fragility. For the comparison of frequencies, the chi-
square or Fischer's exact test with Bonferroni fit. Logistic regression

binary was calculated between the nutritional risk identified by RFH-NPT and CHILD (A
vs BC), adjusted for sex, age, and etilogy of liver disease. Data were expressed
as a 95% confidence interval (CI) and odds ratio (OR). Were
Results with a p-value < 0.05 were considered significant. FINDINGS
PRELIMINARIES: To date, the sample has consisted of 37 patients,
70.3% (n=26) were male and 29.7% (n=11) were female. Ages
ranged from 18 to 70 years, with a mean age of 46.24±15.17 years.

BANKING MEMBERS:
Presidente - 4364569 - FABIANA ANDREA MOURA
Interno(a) - 1791653 - FLAVIO TELES DE FARIAS FILHO
Externo(a) ao Programa - 1727406 - JOAO ARAUJO BARROS NETO
Externo(a) ao Programa - 1042196 - SAMARA BOMFIM GOMES CAMPOS