Banca de QUALIFICAÇÃO: BRENDA ALEXIA DE LIMA THEODOSIO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : BRENDA ALEXIA DE LIMA THEODOSIO
DATE: 31/08/2023
TIME: 14:00
LOCAL: famed
TITLE:

Interrelationship of nutritional profile, risk of sarcopenia, functional capacity and inflammation in chronic kidney disease

KEY WORDS:

Chronic kidney disease, sarcopenia, nutritional perfl

PAGES: 35
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Chronic kidney disease (CKD) is a condition in which progressive loss of kidney function occurs, leading to complications and impacting patients' quality of life. The global increase in the number of CKD cases has led to an increase in hemodialysis (HD). However, HD is associated with complications such as nutritional disorders and chronic inflammation. Knowing this, the present study aimed to evaluate the interrelationship between the nutritional profile, risk of sarcopenia, functional capacity and inflammation, in order to identify groups of patients most vulnerable to these associations. This is a cross-sectional study that was conducted with patients on hemodialysis in the nephrology centers of Hospital Veredas, UNIRIM of Hospital Memorial Arthur Ramos and UNIRIM of Hospital do Coração. The work was divided into three stages, being: 1st application of socioeconomic questionnaires and data collection in medical records; 2nd nutritional assessment, including anthropometry and tests to assess functional capacity; 3rd blood collection and measurement of inflammatory cytokines. The initial sample consisted of 148 participants, most of whom were adults (52.7%) and the remaining elderly, with mean ages of approximately 46.6 years and 70.45 years, respectively. Regarding BMI, 41.7% of the participants were overweight, while 16.7% were underweight. Low strength was observed in 9% of the sample and low velocity in 16.8%. The risk of SARC-F sarcopenia was observed in 31% of participants, while SARC-f+CC was observed in 33%. The inflammatory parameters IL-6 and TNF-α were detected in 82.3% and 49.6% of the participants, respectively. Dialysis was considered inadequate in 19.4% of the participants. The mean Kt/V was better in adults compared to the elderly. It was observed that low weight (n=4; 23.5%) and eutrophy (n=10; 58.8%) presented worse gait speed than overweight patients (n=3; 17.7%). The risk of SARC-F sarcopenia was the same in overweight patients (n=9; 47.4%) and in patients with eutrophy (n=9; 47.4%), while underweight patients only represented 5.2% (n=1). When using SARC-F+CC, more eutrophic patients were classified as at risk (n=16; 53.3%), followed by overweight (n=16; 33.3%), and underweight (n=4; 13.4%). These findings may help in the formulation of more targeted and effective therapeutic strategies to care for this group of patients.

BANKING MEMBERS:
Externo(a) ao Programa - 1640502 - ANTONIO FILIPE PEREIRA CAETANO
Interno(a) - 4364569 - FABIANA ANDREA MOURA
Interno(a) - 7530212 - MERCIA LAMENHA MEDEIROS
Presidente - 2370894 - MICHELLE JACINTHA CAVALCANTE OLIVEIRA