Banca de QUALIFICAÇÃO: PATRICIA ALMEIDA LIRA SANTOS VEIGA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : PATRICIA ALMEIDA LIRA SANTOS VEIGA
DATE: 26/10/2023
TIME: 09:00
LOCAL: famed
TITLE:

Correlation of body composition and ultrasound findings with risk
Cardiovascular Disorders in Patients With Rheumatoid Arthritis

KEY WORDS:

Rheumatoid Arthritis; body composition; cardiovascular risk.

PAGES: 35
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

INTRODUCTION: Rheumatoid Arthritis (RA) is a systemic autoimmune disease characterized by symmetric and additive polyarthritis of large, medium and small joints, with potential for erosion and extra-articular manifestations, in addition to progression to deformities and loss of functional capacity. RA patients are at high risk of cardiovascular disease (CVD), leading to increased morbidity and mortality, and existing CVR screening methods are not sufficient. OBJECTIVES: To determine the correlation between body mass index, ultrasound findings and cardiovascular risk in patients with RA. METHODS: Cross-sectional study carried out on individuals with RA aged 20 years or over, treated at the Rheumatology service of the Professor Alberto Antunes University Hospital (HUPAA) – Federal University of Alagoas (UFAL). Sociodemographic factors and risk factors for CVD were assessed. The Clinical Disease Activity Index (CDAI) and the Health Assessment Questionnaire – Disability Index (HAQ-DI) were applied. Body mass index was performed using the dual-energy radiological absorptiometry (DEXA) method. Risk analysis was also performed using duplex scan of the carotid and vertebral arteries to assess intima-media thickness (IMT) or the presence of atherosclerotic plaques and transthoracic Doppler echocardiography to assess the presence of target organ damage (LOA). RESULTS: The sample consisted of 56 patients with RA with a mean age of 54 and with a higher prevalence of females (91%). The percentage of hypertension was 50%; 23.2% were diabetic, 7.14% were active smokers, overweight occurred in 41% of the sample and obesity in 37.5%. The finding of carotid plaque revealed a significant association with the Framingham Score, thus presenting a greater risk of cardiovascular diseases, regardless of other risk factors. All patients with diabetes were considered be at high cardiovascular risk. Our study demonstrated that the use of immunobiological drugs were associated with lower risk of developing cardiovascular diseases, regardless of other risk factors. Thus, treatments that decrease disease activity in RA may also have beneficial effects on CVD risk. In contrast, the use of corticosteroids can increase CVR, as it increases the prevalence of risk factors. Our sample included 24 patients (42%) using glucocorticoids, 20 of which were considered to have high CVR. CONCLUSION: Our results corroborate previous data in the literature that patients with RA have an increased cardiovascular risk, regardless of the presence of risk factors. The finding of atherosclerotic plaque in carotid arteries demonstrates an increase in this CVR. The next stage of this project will be to correlate these data with body composition findings, assessed using the dual-energy X-ray absorptiometry (DEXA) method, possibly helping to determine CVR scores.

COMMITTEE MEMBERS:
Interno(a) - 1627935 - AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
Interno(a) - 1791653 - FLAVIO TELES DE FARIAS FILHO
Presidente - 1483526 - THIAGO SOTERO FRAGOSO