Association study between Childhood Adversity and Inflammatory Markers in Patients with Systemic Lupus Erytheamus.
systemic lupus erythesus; IL-6; adversity in childhood
Systemic Lupus Erytheatosus (SLE) is a chronic inflammatory disease that affects connective tissue. Of multifactorial etiology, it infringes several organs and systems, simultaneously or alone, with multivariate clinical manifestations, at any stage of the pathology. Among these alterations, we highlight the increase in inflammatory markers, such as IL-6. Adversities in childhood cause neuropsychological damage during the development of the child's central nervous system, as well as the chronic increase in inflammatory markers. This research is a descriptive cross-sectional study with quantitative methodology, with the objective of studying the association between the inflammatory marker IL-6 and adversities in childhood, in women with systemic lupus erytheama treated at the rheumatology outpatient clinic of the University Hospital Prof. Alberto Antunes (HUPAA) of the Federal University of Alagoas, in the city of Maceió. To this end, after signing the free and informed consent form, the hiv-6 IL of these patients should be quantified, as well as the Childhood Trauma Questionnaire, an assessment tool for adolescents and adults, which investigates a history of abuse and neglect during childhood. At the end, the results will be evaluated through the Statistical Package SPSS - version 23. It is noteworthy that all stages of the study should carefully follow the guidelines of resolution 466/12 of the National Health Council.