PPCM PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS MÉDICAS FACULDADE DE MEDICINA Teléfono/Ramal: 32141857
Disertación/Tesis

Clique aqui para acessar os arquivos diretamente da Biblioteca Digital de Teses e Dissertações da UFAL

2024
Disertaciones
1
  • ANDREZA FERREIRA DA SILVA
  • Hemoglobin levels and risk of sarcopenia in patients undergoing treatment hemodialysis in the wild of Alagoas
     
  • Líder : SAMIR BUAINAIN KASSAR
  • MIEMBROS DE LA BANCA :
  • FABIANA ANDREA MOURA
  • FLAVIO TELES DE FARIAS FILHO
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • SAMARA BOMFIM GOMES CAMPOS
  • SAMIR BUAINAIN KASSAR
  • Data: 25-ene-2024


  • Resumen Espectáculo
  • Introduction: Anemia in Chronic Kidney Disease (CKD) results from insufficient production
    of erythropoietin by the kidney and characteristic uremic metabolic changes. The chronic
    anemic condition generates a decrease in the nutrition and oxygenation of the muscle tissue,
    altering its functionality and contributing to sarcopenia, which can worsen the quality of life
    and increase morbidity and mortality, making early detection essential for the initiation of
    interventions. Objectives: To identify whether hemoglobin levels are associated with the risk
    of sarcopenia in patients with chronic kidney disease on hemodialysis in the rural area of
    Alagoas. Methods: Analytical cross-sectional study with individuals aged over 18 years with
    CKD on hemodialysis at the hemodialysis service of Hospital Regional Santa Rita (HRSR) in
    the city of Palmeira dos Índios and at the Hemodialysis and Hypertension Center Antonieta
    Barreto do Centro Manoel André Hospital (CHAMA) in the city of Arapiraca. The study was
    carried out in two stages: data collection from medical records (socioeconomic, demographic
    and clinical), followed by the application of questionnaires (socioeconomic, demographic,
    SARC-F and SARC-FP), nutritional and biochemical assessment. Data were tabulated in the
    Excel® 2010 package and processed by IBM SPSS Software (Statistical Package for the
    Social Sciences) version 26. Associations were made according to Pearson's chi-square test.
    Results: 230 participants were included in the study, mostly elderly (55.7%), male (50.4%),
    illiterate or with incomplete primary education (63.9%) and family income of less than two
    minimum wages (91.3%). Predominantly diabetics (74.8%) with a risk of sarcopenia greater
    than 50%. The Body Mass Index indicated eutrophy in 55.2% of the sample, followed by
    malnutrition (32.6%) and overweight/obesity (12.2%). Arm circumference and calf
    circumference indicated malnutrition in more than 50% of the sample. Hemoglobin showed
    mean values of (10.4±0.12), hematocrit 32.14% (±0.33), creatinine, phosphorus, potassium,
    calcium, pre-dialysis urea, post-dialysis urea respectively: (9, 95±0.15), (5.11±0.09),
    (5.19±0.09), (7.46±0.10), (134.51±1.99) and (39, 55±1.13). The risk of sarcopenia was
    positively associated with the Body Mass Index (p=0.008) and the KTV index (p=0.04).
    Conclusion: Although hemoglobin levels did not show statistical significance with the risk of
    sarcopenia, most patients had low hemoglobin levels. The limitation of the instrument used to

    screen the risk of sarcopenia must be taken into account. On the other hand, variables such as
    BMI and KTV showed statistically significant associations when analyzed with the risk of
    sarcopenia. The socioeconomic factor of the region was presented as a potential influencer of
    the profile found in the study indicating the need for adequate strategies and public policies
    resulting in a decrease in public expenses involving the treatment of individuals since the state
    of Alagoas has a precarious socioeconomic condition.

     
2
  • DANIELLE DE ARAUJO VANDERLEI
  • Evaluation of sarcopenia in the elderly and its association with glomerular filtration from serum creatinine levels

  • Líder : JULIANA CELIA DE FARIAS SANTOS
  • MIEMBROS DE LA BANCA :
  • ANTONIO FILIPE PEREIRA CAETANO
  • FABIANA ANDREA MOURA
  • FLAVIO TELES DE FARIAS FILHO
  • JULIANA CELIA DE FARIAS SANTOS
  • SAMARA BOMFIM GOMES CAMPOS
  • VALFRIDO LEAO DE MELO NETO
  • Data: 08-feb-2024


  • Resumen Espectáculo
  • INTRODUCTION: Serum creatinine is a marker highly used to evaluate renal function, but it has limitations to evaluate elderly people, since it varies according to muscle reserve, inflammation status and diet. Over the years, muscle reserve tends to decrease, which makes the elderly more predisposed to the development of sarcopenia and the current guidelines for assessing glomerular filtration rate do not provide formulas that fit these limitations in the elderly population. OBJECTIVE: The present study aimed to evaluate whether there is an association between sarcopenia and glomerular filtration rate estimated from serum creatinine. MATERIALS AND METHODS: This was a cross-sectional study to be conducted in participants selected by convenience, in which socioeconomic, demographic, clinical, anthropometric and sarcopenia data were collected. Anthropometric evaluation included BMI, waist and calf circumferences, and bioimpedance analyses. Sarcopenia was evaluated according to the criteria proposed by the European Working Group on Sarcopenia in Older People – EWGSOP (2019). The statistical analysis used Student's t-test, chi-square test, simple linear regressions and adjusted for sex and age, all in IBM SPSS software version 21, adopting an alpha value of 5%. RESULTS: The study included 65 elderly participants with chronic kidney disease (CKD), 29 women (44.6%) and 36 men (55.4%), with 55.4% of individuals who declared themselves brown. Of the individuals evaluated, according to the GFR estimated from the formula proposed by BIS1, 87.7% were between stages 3 of Chronic Kidney Disease and 33.84% of all participants were at risk of sarcopenia. CONCLUSION: The work is still ongoing.

3
  • ALINE ARAUJO PADILHA
  • Association of anemia, muscle strength, physical performance and inflammation in hemodialysis

  • Líder : MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • MIEMBROS DE LA BANCA :
  • ANDRE FALCAO PEDROSA COSTA
  • AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
  • FABIANA ANDREA MOURA
  • MARCELA CAVALCANTE DE ANDRADE SILVA
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • SAMARA BOMFIM GOMES CAMPOS
  • Data: 27-feb-2024


  • Resumen Espectáculo
  • Anemia is considered one of the main complications of chronic kidney disease. This study investigated the association of anemia with muscle strength, physical performance and inflammation. It was an analytical cross-sectional observational study with 128 hemodialysis patients, of both sexes, aged 18 years or older and on dialysis for at least 6 months. The patients underwent the gait speed test and the handgrip test, in addition to the collection of inflammatory markers (interleukin-6, tumor necrosis factor and C-reactive protein). In this study, 62.5% were male, with a mean age of 58.4 ± 14.6 years, 47.7% were elderly and 89.9% were hypertensive. Anemia was considered as a dependent variable and was categorized according to the indication for the use of erythropoiesis-stimulating agents (Hb <10 g/dL), 54.7% of the participants had anemia. The comparison of the groups with and without anemia with muscle strength, physical performance and risk of sarcopenia showed no significant association. However, when considering the parameters with greater power to explain anemia in the multivariate adjustment, the elevation of interleukin-6 was considered a risk factor and muscle strength a protective factor for anemia. The importance of these findings contributes to the search for more targeted treatments regarding inflammatory control, in addition to encouraging the performance of physical activity in chronic renal dialysis patients.

4
  • ARYANA ISABELLE DE ALMEIDA NEVES SIQUEIRA
  • Assessment of the importance of sarcopenia associated with quality of life and oxidative stress in patients with chronic liver disease
  • Líder : FABIANA ANDREA MOURA
  • MIEMBROS DE LA BANCA :
  • FABIANA ANDREA MOURA
  • JOAO ARAUJO BARROS NETO
  • JULIANA CELIA DE FARIAS SANTOS
  • LEILA MARIA SOARES TOJAL DE BARROS LIMA
  • VALFRIDO LEAO DE MELO NETO
  • Data: 27-feb-2024


  • Resumen Espectáculo
  • Responsible for protein synthesis, bile production, glucose balance, micronutrient storage, cholesterol production, detoxification and metabolism of some hormones, among others, the liver plays an extremely important role in the body's homeostasis. Constant aggression to the liver by alcohol, viral hepatitis, metabolic and autoimmune diseases can lead to irreversible damage, with impaired liver function. The natural history of chronic liver disease is characterized by a long asymptomatic (silent) or compensated phase (VUILLELESSARD; RODRIGUES; BERZIGOTTI, 2021), which can progress to clinical decompensation, a phase characterized by the systemic manifestation of liver damage. One of the main consequences of advanced chronic liver disease (ACHD) is portal hypertension, which is responsible for the main complications in clinical decompensation that manifests itself with ascites, hepatic encephalopathy and digestive hemorrhage due to rupture of esophagogastric varices. After the first episode of decompensation, the disease progresses more quickly, increasing morbidity and mortality, and the patient should be evaluated for the possibility of liver transplantation (LTx). The transition from compensated cirrhosis to decompensated cirrhosis occurs at a rate of 5 to 7% per year (D'AMICO; GARCIA-TSAO; PAGLIARO, 2006). The progression of decompensated disease can be further accelerated by the development of other complications such as rebleeding, acute kidney injury, with or without the features of hepatorenal syndrome, hepatopulmonary syndrome, portopulmonary hypertension, cirrhotic cardiomyopathy, and bacterial infections. 2018).

     

5
  • ANA CAROLINA ABREU MACHADO
  • EVALUATION OF THE BERLIN INITIATIVE STUDY (BIS 1) EQUATION TO ESTIMATE GLOMERULAR FILTRATION RATE IN THE ELDERLY

  • Líder : MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • MIEMBROS DE LA BANCA :
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • JULIANA CELIA DE FARIAS SANTOS
  • MERCIA LAMENHA MEDEIROS
  • ANDRE FALCAO PEDROSA COSTA
  • DIEGO DERMEVAL MEDEIROS DA CUNHA MATOS
  • PRISCILA SILVA PONTES PEREIRA
  • Data: 27-feb-2024


  • Resumen Espectáculo
  • Aging is a universal biological phenomenon where individuals and their
    organs age at varying rates, influenced by genetic coding and
    environmental factors. The renal system is also affected by this process, presenting
    anatomical, histological, and hemodynamic changes that ultimately lead to
    a reduction considered "physiological" in glomerular filtration rate (GFR).
    (GLASSOCK, 2016). In clinical practice, correctly measuring GFR is extreme
    Importance for the proper classification and follow-up of individuals with
    or not, of chronic kidney disease, aiding in the reduction of complications, as well as in the
    correction of drug doses and in making decisions regarding the need for
    drug therapies, invasive or contrasted procedures. (SCHAEFFNER et
    al., 2012; FERNANDES, et al., 2015). GFR measurement can ideally be done
    by determining the renal clearance of some exogenous substances, such as:
    inulin, iohexol or a radiolabelled molecule (e.g. EDTA). However, these measures
    are invasive, complex to perform and expensive and are rarely used in the
    daily clinical practice. Thus, the measurement of the estimated GFR ends up being more
    frequent through the clearance of creatinine in the urine collected within 24 hours.
    (PÉQUIGNOT et al., 2009). The choice of creatinine for this purpose is due to the fact
    to be produced in the skeletal musculature and to be almost entirely excreted via the kidney,
    having a very low rate of tubular secretion and resorption. This is one more option
    feasible, however, in the elderly, the use of urinary creatinine brings a series of
    particularities that end up interfering with the applicability of this measure. One of the
    main is the difficulty in collecting 24-hour urine due to issues related to
    urinary incontinence, dementia or even immobility, common in this
    population. (PÉQUIGNOT et al., 2009) Being then in the vast majority of cases,
    serum creatinine was used through pre-established and validated formulas for
    achieve this end. In the elderly, the high prevalence of sarcopenia is low
    protein consumption, especially in the most fragile, leads to a reduction in levels
    serum creatinine, which may remain normal even in the elderly with
    reduced renal function. This change in the creatinine/creatinine clearance ratio
    (where creatinine remains constant while clearance tends to decrease) ends
    for generating a challenge when the goal is to reliably measure GFR in the
    elderly population. (ABREU et al., 1998). The most commonly used formula is that of

    Cockroft-Gault (CG) of 1976, where creatinine clearance ml/min = [ (140-age in
    years) x weight in kg / 72 x serum creatinine mg/dl] x 0.85 if female. (PÉQUIGNOT et
    al. 2009). In the last 15 years, new formulas for estimating GFR have been
    developed, including the best known as the Modification of Diet in Renal
    Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI).
    However, its use is still limited in the elderly due to the lack of representativeness
    of this population in the validation studies, and most of them excluded the individuals
    over 70 years. (LENGNAN et al., 2021; XIA, F. et al., 2021). In this context, the
    Berlin Initiative Study has developed a new formula based on creatinine, sex and
    age (BIS 1), in a study where only individuals over 70 were included
    years. (SCHAEFFNER et al., 2012). The aim of the present study is to evaluate the
    diagnostic performance of the BIS 1 equation and compare its agreement
    tool with the most used currently within our population, analyzing the
    possible variables related to the differences found, so that we can have
    a more reliable, low-cost, and easy-to-manage option for measuring renal function
    in elderly patients and serve as a basis for future validation studies with our
    population.

6
  • CATARINA ROSA E SILVA SANTOS
  • Integration of single cell RNA and spatial transcriptome data for investigation of perineural invasion and circadian rhythm in pancreatic adenocarcinoma
  • Líder : CARLOS ALBERTO DE CARVALHO FRAGA
  • MIEMBROS DE LA BANCA :
  • ALYSSON WAGNER FERNANDES DUARTE
  • AMANDA KARINE BARROS FERREIRA RODRIGUES
  • BRUNA DEL VECHIO KOIKE
  • CARLOS ALBERTO DE CARVALHO FRAGA
  • EMISAEL STENIO BATISTA GOMES
  • JUSSARA ALMEIDA DE OLIVEIRA BAGGIO
  • Data: 29-feb-2024


  • Resumen Espectáculo
  • The association between circadian rhythm, perineural invasion, and pancreatic
    adenocarcinoma is a topic of growing interest in medical and scientific research. Pancreatic
    adenocarcinoma is an aggressive form of cancer that originates from the mucus-producing
    cells in the pancreas. These cells are located in the pancreatic ducts and play an important role
    in digestion. Perineural invasion is a process in which cancer cells penetrate the nerves
    surrounding the pancreas. This can occur when neoplastic cells spread beyond the primary
    tumor, affecting adjacent nerve structures. Several studies have shown that disruption of the
    circadian rhythm can promote tumor growth, perineural invasion, and metastasis in patients
    with pancreatic adenocarcinoma. It is believed that the dysregulation of genes involved in the
    circadian rhythm, such as the PER2 gene, may contribute to disease progression. Additionally,
    changes in sleep patterns, night shift work, and exposure to artificial light at night have been
    associated with an increased risk of developing this type of cancer. The present study aims to
    understand the interaction between circadian rhythm and perineural invasion in the context of
    pancreatic adenocarcinoma. For this purpose, scRNA (single-cell RNA) and spatial
    transcriptome data will be used to analyze the molecular and spatial characteristics of cancer
    cells, nerve cells, and the surrounding environment. A systematic review of pancreatic
    adenocarcinoma studies was conducted using the Gene Expression Omnibus (GEO-NCBI)
    database, from which studies were selected to identify the inflammatory processes associated
    with the injury. These studies were analyzed using a pipeline developed in the R programming
    language to standardize the processing of single-cell RNA sequencing and spatial
    transcriptome gene expression data. The pipeline allows for downloading data from GEO,
    quality control analysis, normalization, identification and removal of potential outliers,
    summarization of gene expression data, gene annotation, identification of cells present in the
    samples, and analysis of differentially expressed genes (DEGs). The processed scRNA-seq
    data and annotation tables were downloaded from the GEO database. The dataset consisted of
    180,000 cells corresponding to 36 patients with brain metastasis. Untreated samples were
    specified and investigated to eliminate unnecessary factors. Separately, the cell count matrices
    of the selected samples were introduced into R (4.1.0) and analyzed for cellular composition,
    cell-cell interaction, and spatial transcriptome. The data were analyzed using specific
    packages in R software, demonstrating that there are gene expression patterns in the different
    analyzed samples. Our observations expand the notion by identifying that proliferative and
    inflammatory processes coexist as opposing main cellular states and suggest that immune
    escape and proliferation act as combined events. The present study identifies neoplastic,
    stromal, and immune cell types in different types of pancreatic adenocarcinoma and presents
    hypotheses to understand the interaction between intrinsic characteristics of tumor cells and
    host environment characteristics in human metastasis.

7
  • PATRICIA ALMEIDA LIRA SANTOS VEIGA
  • Correlation of body composition and ultrasound findings with risk
    Cardiovascular Disorders in Patients With Rheumatoid Arthritis

  • Líder : THIAGO SOTERO FRAGOSO
  • MIEMBROS DE LA BANCA :
  • THIAGO SOTERO FRAGOSO
  • AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
  • FLAVIO TELES DE FARIAS FILHO
  • ANTONIO LUIZ RIBEIRO BOECHAT
  • Data: 25-abr-2024


  • Resumen Espectáculo
  • INTRODUCTION: Rheumatoid Arthritis (RA) is a systemic autoimmune disease characterized by symmetric and additive polyarthritis of large, medium and small joints, with potential for erosion and extra-articular manifestations, in addition to progression to deformities and loss of functional capacity. RA patients are at high risk of cardiovascular disease (CVD), leading to increased morbidity and mortality, and existing CVR screening methods are not sufficient. OBJECTIVES: To determine the correlation between body mass index, ultrasound findings and cardiovascular risk in patients with RA. METHODS: Cross-sectional study carried out on individuals with RA aged 20 years or over, treated at the Rheumatology service of the Professor Alberto Antunes University Hospital (HUPAA) – Federal University of Alagoas (UFAL). Sociodemographic factors and risk factors for CVD were assessed. The Clinical Disease Activity Index (CDAI) and the Health Assessment Questionnaire – Disability Index (HAQ-DI) were applied. Body mass index was performed using the dual-energy radiological absorptiometry (DEXA) method. Risk analysis was also performed using duplex scan of the carotid and vertebral arteries to assess intima-media thickness (IMT) or the presence of atherosclerotic plaques and transthoracic Doppler echocardiography to assess the presence of target organ damage (LOA). RESULTS: The sample consisted of 56 patients with RA with a mean age of 54 and with a higher prevalence of females (91%). The percentage of hypertension was 50%; 23.2% were diabetic, 7.14% were active smokers, overweight occurred in 41% of the sample and obesity in 37.5%. The finding of carotid plaque revealed a significant association with the Framingham Score, thus presenting a greater risk of cardiovascular diseases, regardless of other risk factors. All patients with diabetes were considered be at high cardiovascular risk. Our study demonstrated that the use of immunobiological drugs were associated with lower risk of developing cardiovascular diseases, regardless of other risk factors. Thus, treatments that decrease disease activity in RA may also have beneficial effects on CVD risk. In contrast, the use of corticosteroids can increase CVR, as it increases the prevalence of risk factors. Our sample included 24 patients (42%) using glucocorticoids, 20 of which were considered to have high CVR. CONCLUSION: Our results corroborate previous data in the literature that patients with RA have an increased cardiovascular risk, regardless of the presence of risk factors. The finding of atherosclerotic plaque in carotid arteries demonstrates an increase in this CVR. The next stage of this project will be to correlate these data with body composition findings, assessed using the dual-energy X-ray absorptiometry (DEXA) method, possibly helping to determine CVR scores.

8
  • GABRIELA MARIA DE ANDRADE CORREIA
  • Polymerase Chain Reaction as a Diagnostic Complement for Turner Syndrome and Gonadal Dysgenesis 46,XX in the Unified Health System of Alagoas.

  • Líder : REGINALDO JOSE PETROLI
  • MIEMBROS DE LA BANCA :
  • ALESSANDRA PLACIDO LIMA LEITE
  • Fernanda Caroline Soardi
  • JOSE ROBERTO DE OLIVEIRA FERREIRA
  • JULIANA CELIA DE FARIAS SANTOS
  • MANOEL ALVARO DE FREITAS LINS NETO
  • REGINALDO JOSE PETROLI
  • Data: 26-abr-2024


  • Resumen Espectáculo
  • Introduction: Gonadal Dysgenesis (GD) is classified as Sex Development Disorder/Differences (DSD) and is characterized by impaired gonad development. GD can be classified as Complete Gonadal Dysgenesis (GDC), Mixed Dysgenesis (GDM) or Partial Gonadal Dysgenesis (GDP). Turner Syndrome (TS), related to alterations in the X chromosome, is one of the most prevalent syndromes in females and impairs gonadal development. Individuals with GD and TS are at increased risk for developing germline tumors due to abnormalities in gonad organogenesis, which are aggravated by the presence of Y chromosome markers. Objective: To investigate Y chromosome markers in cases diagnosed with TS and GD 46,XX treated at the SUS of Alagoas. Methods: This is a cross-sectional, observational, descriptive study with a sample consisting of individuals with a clinical and cytogenetic diagnosis of TS and GD 46,XX, regardless of age, treated at the SUS in Alagoas between May 2008 and May 2023. To describe the sample, medical records with sociodemographic, clinical, cytogenetic and molecular data were analyzed. The molecular investigation of Y markers took place through Conventional Polymerase Chain Reaction (PCR) and NESTED. All results were organized in an Excel spreadsheet for later analysis. Results: From a sample of 233 cases of DSD treated at the Clinical Genetics Service of the Professor Alberto Antunes University Hospital (SGC/HUPAA), 12 had GD 46.XX and 34 had TS. All cases with 46.XY karyotypes and cases with 46.XX karyotypes without clinical characteristics of DG and TS were excluded.  The sample of this study consisted of 46 participants. Of these, 60.87% of the participants came from the interior of Alagoas, 32.61% from the capital and 6.52% did not have information on origin. The mean age for the first visit was 16.91 years, with primary amenorrhea, short stature, and delayed development of secondary sex characteristics. 73.91% of the cases were clinically diagnosed with TS, while 26.09% were diagnosed with Gonadal Dysgenesis 46.XX. The presence of Y chromosome markers was observed in 4.35% of the sample and 95.35% did not present the investigated markers. Discussion: According to the literature, about 4-60% of TS cases may have Y-specific sequences in their chromosomal constitution. On the other hand, for DG 46,XX, these data are not presented in the literature. Cases with DG 46,XX and ST, which have Y chromosome markers in their chromosomal constitution, have an increased risk for the development of gonadal tumors and prophylactic gonadectomy is indicated in these cases. Conclusion: The investigation of Y markers was performed in 34 individuals with clinical and cytogenetic diagnosis of TS and 12 individuals with GD 46,XX. PCRs revealed Y chromosome markers in 2 participants of the sample, both with TS. Participants who did not present Y markers remain under investigation.

9
  • ELEN BATISTA DANTAS
  • CHANGES IN THE GLOMERULAR FILTRATION RATE IN THE ELDERLY LIVING IN COMMUNITIES IN THE STATE OF ALAGOAS AND ITS ASSOCIATION WITH SARCOPENIA
  • Líder : JULIANA CELIA DE FARIAS SANTOS
  • MIEMBROS DE LA BANCA :
  • ENAIANE CRISTINA MENEZES
  • JULIANA CELIA DE FARIAS SANTOS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • SANDRA MARY LIMA VASCONCELOS
  • Data: 30-abr-2024


  • Resumen Espectáculo
  • INTRODUCTION: Chronic kidney disease (CKD) is known to be associated with a systemic catabolic state, patients are commonly at high risk of sarcopenia, being a prevalent complication that negatively interferes in the quality of life of elderly. OBJECTIVE: To evaluate changes in glomerular filtration rate (GFR) in elderly living in communities in the State of Alagoas and its association with Sarcopenia. MATERIALS AND METHODS: This is an observational, analytical and descriptive study, cross-sectional population-based model, an integral part of a larger project called I Alagoas Diagnosis on health and quality of life of the elderly, carried out from April 2021 to October 2023 in the State of Alagoas. A The sample of this study will consist of a subsample of the main project, formed by 500 elderly people (age > 60 years) residing in 14 municipalities in the State of Alagoas. Socioeconomic, demographic, clinical, biochemical, anthropometric, body composition, muscle strength and physical performance.
10
  • EDUARDO LIMA BARBOSA
  • TIME TO DIAGNOSIS OF SYSTEMIC LUPUS ERYTHEMATOSUS IN THE SYSTEM

  • Líder : THIAGO SOTERO FRAGOSO
  • MIEMBROS DE LA BANCA :
  • AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
  • KLAYSA MOREIRA RAMOS
  • THIAGO SOTERO FRAGOSO
  • VALFRIDO LEAO DE MELO NETO
  • Data: 28-jun-2024


  • Resumen Espectáculo
  • Systemic Lupus Erythematosus (SLE) is one of the most important rheumatic autoimmune diseases
    prevalent in the population and affects mainly working-age adults. LES has a
    Varied clinical course, and may present as a relatively benign disease up to a
    rapidly progressive disease, with organ failure and fulminant death. The improvement in
    Patient survival is probably due to several factors, including increased
    recognition of the disease with more sensitive diagnostic tests; early diagnosis; the
    increasingly judicious therapy and the immediate treatment of complications. It is known that the treatment
    specific with corticosteroids and immunosuppressive drugs, when started immediately after
    the appearance of symptoms, have greater chances of obtaining an effective response, including to the
    total remission of the symptomatic picture. Therefore, the early diagnosis of the disease is necessary,
    having as a direct result the prevention of serious complications. Objective: to check the interval
    of time between the onset of SLE symptoms and definitive diagnosis. Methodology: this is
    a cross-sectional study with a qualitative and quantitative approach with a duration of 12 (twelve)
    months and will be held in the outpatient clinic and in the rheumatology ward of the University Hospital
    Professor Alberto Antunes (HPAA) of the Federal University of Alagoas and the sample will be
    consisting of individuals with SLE who present themselves for routine consultation at the
    Rheumatology outpatient clinic, or are hospitalized at the Professor University Hospital
    Alberto Antunes (HC) of the Federal University of Alagoas (UFAL) and who meet the criteria of
    inclusion/exclusion from the study and agree and sign the free and informed consent term.

11
  • MARINA DEMAS REZENDE GISCHEWSKI
  • Strategies for diagnosing sarcopenia and their agreement with
    Traditional methods of assessing nutritional status in patients with
    liver cirrhosis

  • Líder : FABIANA ANDREA MOURA
  • MIEMBROS DE LA BANCA :
  • ANTONIO FILIPE PEREIRA CAETANO
  • FABIANA ANDREA MOURA
  • JOAO ARAUJO BARROS NETO
  • LEILA MARIA SOARES TOJAL DE BARROS LIMA
  • RALMONY DE ALCANTARA SANTOS
  • VALFRIDO LEAO DE MELO NETO
  • Data: 22-jul-2024


  • Resumen Espectáculo
  • INTRODUCTION: Liver transplantation (HTT) is the treatment of choice for cases
    acute or chronic end-stage liver disease, provided that the benefits of
    treatment outweigh the risks inherent in the procedure. While the patient is on the list
    Waiting, the team should focus on the management of the underlying disease and complications, to
    that is in adequate conditions at the time of TxH. In these individuals it is observed
    a metabolic change in the primary fuel from glucose to fatty acids and
    proteins, combined with a reduction in protein synthesis which also contributes to the
    muscle depletion and installation of sarcopenia. Also seen in patients with liver disease, the
    frailty manifests as loss of muscle function, beyond dimensions
    psychological and social, being amenable to reversal when properly diagnosed.
    The presence of these nutritional extremes is directly related to the inflammatory process
    related to the underlying mechanism of disease, which is intrinsically linked to stress
    oxidative. OBJECTIVE: To identify how nutritional status, frailty and sarcopenia
    are associated with the presence of inflammation and oxidative stress in candidates for
    liver transplantation. MATERIALS AND METHODS: This is a cross-sectional study,
    whose data collection, in progress, began in October 2022, after approval by the
    Research Ethics Committee of the Federal University of Alagoas, with a forecast of
    end in August 2023, at the pre and post liver transplant outpatient clinic of the Hospital
    University Professor Alberto Antunes. Screening tools and
    nutritional assessment for cirrhotic RFH-NPT and RFH-GA, screening for
    sarcopenia as recommended by the EWGSOP2 and frailty through the

    Liver Fragility. For the comparison of frequencies, the chi-
    square or Fischer's exact test with Bonferroni fit. Logistic regression

    binary was calculated between the nutritional risk identified by RFH-NPT and CHILD (A
    vs BC), adjusted for sex, age, and etilogy of liver disease. Data were expressed
    as a 95% confidence interval (CI) and odds ratio (OR). Were
    Results with a p-value < 0.05 were considered significant. FINDINGS
    PRELIMINARIES: To date, the sample has consisted of 37 patients,
    70.3% (n=26) were male and 29.7% (n=11) were female. Ages
    ranged from 18 to 70 years, with a mean age of 46.24±15.17 years.

12
  • LUNA LIRA BERGAMINI
  • Fear of childbirth in the puerperal period

  • Líder : MERCIA LAMENHA MEDEIROS
  • MIEMBROS DE LA BANCA :
  • ALESSANDRA PLACIDO LIMA LEITE
  • AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
  • MERCIA LAMENHA MEDEIROS
  • REGINALDO JOSE PETROLI
  • TELMO HENRIQUE BARBOSA DE LIMA
  • Data: 29-jul-2024


  • Resumen Espectáculo
  • Introduction: The fear of childbirth is referred to as an irrational fear of the approaching birth, affecting the mental health of women in the pregnancy-puerperal cycle. The most widely used research instrument is currently the Wijma Delivery Expectancy/Experience Questionnaire, which has been translated into several languages and can be applied both in the gestational and postpartum periods, versions A and B, respectively. The present study aimed to perform a cross-cultural adaptation of version B of the questionnaire for the Portuguese of Brazil and then apply the instrument in a sample of Brazilian puerperal women.

    Methodology: We conducted a cross-sectional study covering a process of cross-cultural adaptation of WDEQ-B in Portuguese of Brazil, and then applied the instrument to 186 postpartum women hospitalized in three different public maternity hospitals in Maceió, in the state of Alagoas. Clinical-obstetric information and perception of social support of the puerperal women were also evaluated, considering possible associations with severe fear of childbirth.

    Results: A cross-cultural adaptation of the WDEQ-B was performed, with reasonable correspondence of the original instrument and widely understood by the participants. The prevalence of severe fear of childbirth found in our sample was 7.54% (mean 62.95). The non-occurrence of complete high school education proved to be a protective factor against severe fear of childbirth, with a prevalence ratio of 0.24 (CI 0.03 - 0.85) p = 0.03. The following variables showed a positive correlation with severe fear of childbirth: perception of low social support (prevalence ratio 3.83, CI 1.39 - 10.51 and p < 0.01), disagreement between preference of mode of delivery and current delivery (prevalence ratio 4.97, CI 1.43 - 17.27 and p < 0.01) and presence of diabetes mellitus prior to pregnancy (prevalence ratio 3.32, CI 1.14 - 9.64, p = 0.03).

    Conclusions: The WDEQ-B was successfully adapted to the Brazilian Portuguese and proved to be an adequate research instrument to identify the presence of severe fear of childbirth among Brazilian women in the puerperal period. The results found raise several questions about the fear of childbirth in Brazil, emphasizing the importance of expanding our knowledge in this area.

13
  • ALEXANDRE OTILIO PINTO JUNIOR
  • ASSOCIATION BETWEEN LONELINESS, PSYCHOLOGICAL PAIN, AND DEPRESSION WITH THE IMPACT OF FIBROMYALGIA ON ADULT WOMEN.

  • Líder : VALFRIDO LEAO DE MELO NETO
  • MIEMBROS DE LA BANCA :
  • AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
  • CRISTIANE MONTEIRO DA CRUZ
  • JORGE ARTUR PECANHA DE MIRANDA COELHO
  • THIAGO SOTERO FRAGOSO
  • VALFRIDO LEAO DE MELO NETO
  • Data: 30-jul-2024


  • Resumen Espectáculo
  • According to the American College of Rheumatology (American College of
    Rheumatology – ACR), Fibromyalgia (FM) is a chronic and complex disease,
    characterized by moderate to severe pain at specific muscle points
    (tender points). The prevalence of FM is 2 to 5% of the population, estimated in Brazil at 2.5%.
    most frequently affecting women with an average age between 30 and 50 years, however,
    Symptoms can appear at any age. Commonly, it is accompanied by fatigue,
    sleep disorders, headache, systemic dysfunctions such as irritable bowel syndrome, cystitis
    interstitial; as well as cognitive and psychological changes. Pain is the most common symptom,
    mostly related to allodynia and hyperalgesia, and is considered a limiting factor
    to carry out activities of daily living and work. A Spanish study from this year
    noticed that women with FM had a higher rate of psychopathological alterations,
    such as somatization, OCD, depression, and anxiety when compared to those who did not have
    diagnosis of FM. Depression is the leading mental condition that affects people living
    with FM, which leads them to the restriction of activities and personal relationships. (ANAYA et al., 2021;
    CUYUL-VÁSQUEZ et al., 2021; GRAMINHA et al., 2021).
    Psychological Pain (PD) can also be found in the literature as mental pain,
    psychic suffering, psychic pain, emptiness or internal disturbance. PD being understood
    as an unpleasant state of consciousness, resulting from experiences of loss, which leads to the
    breakdown of individual and social integrity. Also, during a depressive episode the pain
    The psychological crisis had been described as worse than any physical pain an individual had ever felt.
    The concept of loneliness can be defined as a cognitive perception that people
    social relationships are insufficient or inadequate, which results in a feeling of
    of emptiness or sadness. In 1978, the first version of the Loneliness Scale of
    UCLA, which already showed a moderate correlation with screening for depression, having
    showed improvement in this relationship with its most current version, being one of the most
    used (BARROSO et al., 2016; LUIS, 2016).

2023
Disertaciones
1
  • LILYANA WALESKA NUNES ALBUQUERQUE
  • Development of a new diagnostic method and in vitro evaluation of a new therapeutic strategy for leishmaniasis

  • Líder : ALINE CAVALCANTI DE QUEIROZ
  • MIEMBROS DE LA BANCA :
  • ALINE CAVALCANTI DE QUEIROZ
  • ANDRESSA LETICIA LOPES DA SILVA
  • CAMILA DE BARROS PRADO MOURA SALES
  • FABIANA ANDREA MOURA
  • GLAUBER JOSE FERREIRA TOMAZ DA SILVA
  • JULIANA CELIA DE FARIAS SANTOS
  • Data: 26-ene-2023


  • Resumen Espectáculo
  • Introduction: Leishmaniasis is a neglected disease that, despite its epidemiological importance, still has limitations in terms of diagnosis, either because of the gold standard using an invasive biological sample collection method, or because of the variation in sensitivity, requirement of laboratory structure, highly qualified technicians. or high cost of other methods used. Objective: The present study aims to carry out a technological prospection of patents that indicate new immunodiagnostic methods for human tegumentary leishmaniasis in the last 10 years, aiming at diagnostic alternatives with a greater degree of sensitivity and specificity, of easy utilization and lower cost.Methods: This review of patent literature used six patent databases: The LENS, WIPO, EPO, USPTO, Patent Inspiration, Google patents and INPI.Results: 630 patents were analyzed, of which 13 were selected according to combinations of descriptors and study criteria. The information gathered here covered the main characteristics of the immunodiagnostic methods evaluated. Conclusion: In conclusion, the present prospective study indicated the biotechnological advances in the immunodiagnosis of cutaneous leishmaniasis in the last decade, especially in Brazil, which has the largest number of patents on new methods for the immunodiagnosis of cutaneous leishmaniasis. However, despite being a neglected disease, in the last three years no patent document on the subject was found, which raises a concern about the diagnosis of leishmaniasis.

2
  • VANESSA MIRANDA PEREIRA FAUSTO
  • METABOLOMIC BIOMARKERS AS PREDICTORS OF CARDIOVASCULAR RISK IN PATIENTS WITH SYSTEMIC LUPUS ERYTHESUM

  • Líder : THIAGO SOTERO FRAGOSO
  • MIEMBROS DE LA BANCA :
  • ANTONIO LUIZ RIBEIRO BOECHAT
  • AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
  • FLAVIO TELES DE FARIAS FILHO
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • RODRIGO PEIXOTO CAMPOS
  • THIAGO SOTERO FRAGOSO
  • Data: 27-feb-2023


  • Resumen Espectáculo
  • INTRODUCTION: Systemic Lupus Erytheamus is a chronic, immunomediated inflammatory disease, where the loss of immune regulation and the presence of autoantibodies result in multiple organ involvement. Lupus patients have increased cardiovascular risk compared to healthy people of the same sex and age. Existing methods of cardiovascular risk screening are not sufficient for patients with Systemic Lupus Erytheamus. OBJECTIVES: To evaluate metabolomic biomarkers that may be predictors and aid for cardiovascular risk assessment in this population. MATERIALS AND METHODS: Observational study and cross-sectional cohort. The sample was selected by convenience, composed of patients with SLE by the Rheumatology outpatient clinic of the Professor Alberto Antunes Hospital, a tertiary hospital in a northeastern capital. Patients of both sexes over the age of 18 years were included and signed the Free Consent and Informed Consent Form (Informed Consent). For the comparative analysis, the sample of patients control by convenience was also selected, composed of people of both sexes aged over 18 years who did not have autoimmune disease. These control patients also signed the Free Consent and Informed Consent Term (TCLE). Blood examination was collected at the Laboratory of the Professor Alberto Antunes University Hospital and a sample was sent to the Chemistry Laboratory of the Federal University of Alagoas for metabolomics evaluation. Subsequently, a statistical comparison of patients with Lupus and controls will be performed.

3
  • TENILDO LOPES
  • PATIENT WITH SISTEMIC LUPUS ERYTHESIS AND ITS ASSOCIATION WITH FATIGUE, CLINICAL PARAMETERS AND DRUG THERAPY

  • Líder : THIAGO SOTERO FRAGOSO
  • MIEMBROS DE LA BANCA :
  • FLAVIO TELES DE FARIAS FILHO
  • MARIA DO SOCORRO MENESES DANTAS
  • MERCIA LAMENHA MEDEIROS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • THIAGO SOTERO FRAGOSO
  • VALFRIDO LEAO DE MELO NETO
  • Data: 08-mar-2023


  • Resumen Espectáculo
  • INTRODUCTION: Systemic Lupus Erythesus (SLE) is an autoimmune disease that affects several organs and is associated with fatigue. In addition, the patient of this disease suffers losses in daily activities with impairment in functional capacity with low level of muscle strength and postural instability. In addition, with the evolution of the disease, there is an increase in the risk of fall and low physical conditioning. OBJECTIVES: To verify the level of fatigue in patients with systemic lupus erythesus; Evaluate the level of handgrip strength in patients with systemic lupus erytheamsum; Analyze functional capacity in patients with systemic lupus erythesus; Evaluate the strength of the lower limbs in patients with systemic lupus erythesus; Assessing the handgrip strength in patients with systemic lupus erythesus MATERIALS AND METHODS: An observational, cross-sectional study was performed in patients with confirmed diagnosis Systemic Lupus Erytheamus (SLE) followed at the Professor Alberto Antunes University Hospital – Federal University of Alagoas in the city of Maceió-AL. The sample was composed of people from 18 years of age, in which all signed the Free Consent and Informed Consent Term (TCLE). The variables of analysis were: anthropometric measurements such as weight, height and BMI; systemic lupus erithematosus disease activity index); functional capacity through handgrip tests, sitting and lifting of the chair 5 times and static balance; verification of the presence of fatigue through the Fatigue Severity Scale; verification of covid-19 contagion and post-covid-19 sequelae through self-report and socio-demographic questionnaire. Descriptive analyses were performed using mean, standard deviation, relative and absolute frequency for continuous variables and percentage for binary variables. The Shapiro-Wilk test was used to verify the normality of the distribution of continuous variables. In the normal condition of the data, the comparison between two means will be made by the t-Student test. In the case of non-normality of the data, the Mann-Whitney test was applied. P< 0.05 values were considered statistically significant. FINDINGS; The sample presented a predominance of 100% female, mean time of disease installation 9.1 years, no patient reported using alcohol or smoking, 23% reported having hypertension and 10% diabetes, mean age of 40.1±12.5, weight 66.2±13.1, BMI 26.0 ±4.9, regarding physical activity practice 75% reported not doing any type of exercise,  80% of the patients revealed to have taken the covid vaccine on average 2.6 ±0.9, among the functional capacity test 92% of the patients were above the cutoff point of 13 seconds in the sit and lift test 5 times, in the static balance test only 10% presented difficulties in the monopedal phase and could not complete the test,  in the right handgrip test value in kilos in the right hand 10.0 ±6.3 left hand 9.1 ±5.9, among the verification of the fatigue severity scale the mean value was 35.5 ±16.8, in the items that focus on constant physical performance, obligation, responsibilities, disabilities and in the social and family relationship the mean value was above the cutoff point 4.0,  among the medications used were Hydroxychloroquine and Azathioprine CONCLUSION: the results of the present study demonstrate that the presence of fatigue in the activities of daily living of patients with systemic lupus erytheams, has impaired their obligations and responsibilities especially in those who depend on the performance of some physical effort, the presence of fatigue also influences the low level of physical activity increasing body composition and the emergence of new diseases  hypertension and diabetes.

4
  • ÍCARO RAPHAEL SOUZA DOS SANTOS
  • ASSOCIATION BETWEEN LEVEL OF PHYSICAL ACTIVITY AND CIRCADIAN PREFERENCE IN PATIENTS WITH SYSTEMIC ERYTHESUM LUPUS

  • Líder : THIAGO SOTERO FRAGOSO
  • MIEMBROS DE LA BANCA :
  • ALEXANDRE URBAN BORBELY
  • AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
  • FLAVIO TELES DE FARIAS FILHO
  • MARIA DO SOCORRO MENESES DANTAS
  • THIAGO SOTERO FRAGOSO
  • VALFRIDO LEAO DE MELO NETO
  • Data: 09-mar-2023


  • Resumen Espectáculo
  • INTRODUCTION: Systemic lupus erithematosus (SLE) is an autoimmune condition of multisystem character associated with significant morbidity and mortality rates. Physical inactivity is highly prevalent in individuals with SLE. The phenotypic expression of an individual’s circadian rhythm or circadian preference is closely related to biological variables, and as a result it might influence the level of physical activity and clinical conditions in a population. OBJECTIVES: This study aimed at determining levels of physical activity and their associations with circadian preferences and clinical parameters in systemic lupus erythematosus. MATERIALS AND METHODS: SLE patients according to ACR’s criteria for diagnosis were included in this research. Physical inactivity was assessed through IPAQ short form. Circadian preference was assessed via MEQ. Disease activity and damage were assessed through modified SLEDAI-2K and SLICC. Data was analysed statiscally considering p < 0,05

5
  • GRAZIELA CYNTIA SILVA SANTOS
  • EARLY FEEDBACK AFTER CESAREAN IN A PRIVATE HOSPITAL IN MACEIÓ: IMPACT ON THE HEALTH OF THE MATERNAL-FETAL BINOMIUM
  • Líder : FABIANA ANDREA MOURA
  • MIEMBROS DE LA BANCA :
  • FABIANA ANDREA MOURA
  • JULIANA CELIA DE FARIAS SANTOS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • SAMIR BUAINAIN KASSAR
  • ALANE CABRAL MENEZES DE OLIVEIRA
  • ANDREA MARQUES VANDERLEI FREGADOLLI
  • Data: 21-mar-2023


  • Resumen Espectáculo
  • The international protocol ERAS (Enhanced Recovery After Surgery), published in 2005 on the European continent, brings a series of recommendations backed by scientific evidence for perioperative care and improvements in patient recovery (Eras Society, 2021). Based on this protocol, the ACERTO project – Acceleration Total Post-Operative Recovery - which deals, among others, with issues nutritional supplements in the recovery of the surgical patient and points out measures that reduce postoperative complications and reduce the length of hospital stay, without increase in readmission rates (EDUARDO, 2017) . As recommended by the ERAS protocol for pregnant women (WILSON et al. al., 2018) , in preoperative fasting, women should be encouraged to drink liquids clear (juice without residue, coffee or tea) up to 2 hours before surgery and a light meal can be consumed up to 6 hours before surgery. In the same vein, the Society of Anesthesiology (SMITH et al., 2011) already recommended that children and adults should be encouraged to drink clear fluids up to two hours before elective surgery, including cesareans.
6
  • KAROLINE BÁRBARA DA SILVA OLIVEIRA
  • Handgrip strength and corrected arm muscle area as risk factors for clinical outcomes and mortality in patients with chronic kidney disease on hemodialysis

  • Líder : RODRIGO PEIXOTO CAMPOS
  • MIEMBROS DE LA BANCA :
  • FABIANA ANDREA MOURA
  • FLAVIO TELES DE FARIAS FILHO
  • JULIANA CELIA DE FARIAS SANTOS
  • RODRIGO PEIXOTO CAMPOS
  • SAMARA BOMFIM GOMES CAMPOS
  • Data: 25-abr-2023


  • Resumen Espectáculo
  • INTRODUCTION: Chronic kidney disease (CKD) negatively affects muscle health
    with consequent increase in frailty. Especially in patients undergoing
    hemodialysis (HD), peculiar factors of the pathology and the dialysis process favor the
    decline in nutritional status, greater fragility and risk of falls and fractures in these
    patients, negatively impacting quality of life and contributing to a worse
    prognosis. OBJECTIVES: To investigate the association of muscle strength and muscle mass
    reduced in patients with CKD on HD and their impact as a risk factor for
    hospitalizations, cardiovascular events, and mortality. MATERIAL AND METHODS:
    This is a prospective cohort, carried out with 300 patients between 18 and 80 years of age, in
    Chronic HD. Muscle strength was measured by handgrip strength (HGS) and
    muscle mass by the equation estimating the corrected arm muscle area (AMBc).
    Patients were classified as reduced HGS as HGS<26kg for men and
    <16kg for women. Those were classified with muscle depletion by AMBc
    who presented values ≤15th percentile according to sex and age group. The patients were
    followed for a minimum period of 9 months to observe the incidence of
    clinical outcomes investigated. For analysis of the association between reduced HGS and AMBc
    and clinical outcomes, the Kaplan-Meier survival curve and the logrank test were used. A multivariate analysis was also performed using the regression model of
    Cox proportional hazards presented as hazard ratio (RR) at intervals of
    95% confidence (95% CI) and considered significant when p<0.05.
    RESULTS: Reduced FMF was significantly associated with Mass Index
    Body (BMI) and type of vascular access (p=<0.05). The reduced AMBc was also
    associated with BMI (p=0.015), in addition to longer HD time (p<0.001). According to analysis
    of regression, it was evidenced that HGS and reduced AMBc presented themselves as factors
    of significant risk for the incidence of hospitalizations (p<0.001) and events
    cardiovascular (p=0.025). The reduced AMBc is still strongly associated with
    increased relative risk for mortality (p=0.020). CONCLUSION: Patients with
    CKD on HD that showed reduced muscle strength and muscle mass measured by
    HGS and AMBc have a higher risk for the incidence of hospitalizations, events
    cardiovascular and mortality when compared to patients with HGS and AMBc
    Normal.

7
  • LARISSA STHEFANE SANTANA DA CUNHA
  • Assessment of Covid-19 fear, anxiety and quality of life in chronic renal patients

  • Líder : MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • MIEMBROS DE LA BANCA :
  • JULIANA CELIA DE FARIAS SANTOS
  • MERCIA LAMENHA MEDEIROS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • SAMIR BUAINAIN KASSAR
  • THIAGO SOTERO FRAGOSO
  • VALFRIDO LEAO DE MELO NETO
  • Data: 26-may-2023


  • Resumen Espectáculo
  • Introduction: COVID-19, a disease caused by Sars-Cov-2 or new Coronavirus since its appearance in Wuhan (China), has aroused fear and apprehension on a global scale due to its rapid spread. The consequences caused by the new Coronavirus were mainly sanitary and psychological, with a cluster of cases of depression, anxiety and domestic violence. Studies conducted in China early in the pandemic identified chronic kidney disease as a risk factor for worsening the disease and mortality in COVID-19 infected patients. Objectives: To evaluate the fear of COVID-19, anxiety and quality of life in the study participants with chronic dialysis and non-dialysis patients. In addition to characterizing the socioeconomic, demographic and clinical profile of the population studied, patients according to the scale of fear and anxious trait, measure anxious trait and fear with clinical and laboratory data and associate quality of life and anxiety disorder in chronic renal patients. Methodology: The research is a cross-sectional study that is being conducted through the application of questionnaires, including the quality of life scale with SF-36 instrument, the State Trait Anxiety Inventory (STAI) and the COVID-19 fear scale. The study is being conducted in chronic renal participants treated at conservative treatment outpatient clinics for chronic kidney disease treated at the Nephrology outpatient clinic of the Prof. Alberto Antunes University Hospital (HUPAA/UFAL). Results: To date, 47 chronic renal patients have been approached, all non-dialysis. Being 22 males and 25 females. The mean age of the participants ranged from 18 to 97 years of age, and most are over 60 years of age. More than 50% of the sample is brown, living in Maceió, has a partner (a) and took the vaccine for COVID-19. The other questionnaires have not yet been analyzed for the scores. Conclusion: With the research it is expected to know whether the fear of COVID-19 decreased in chronic renal patients after vaccination, whether dialysis has higher levels of anxiety than those on conservative treatment and whether the fear of COVID-19 is higher in more inflamed chronic renal.

8
  • KASSIA ALICE ANJOS DE LIMA
  • EPIDEMIOLOGICAL APPROACH AND SPACE-TIME DIN MICA OF LEPROSY AND DISABILITIES IN THE POPULATION OF ALAGOAS

  • Líder : CAROLINNE DE SALES MARQUES
  • MIEMBROS DE LA BANCA :
  • ALDA GRACIELE CLAUDIO DOS SANTOS ALMEIDA
  • ALYSSON WAGNER FERNANDES DUARTE
  • CAROLINNE DE SALES MARQUES
  • CHRISTEFANY REGIA BRAZ COSTA
  • CLODIS MARIA TAVARES
  • JULIANA CELIA DE FARIAS SANTOS
  • Data: 30-jun-2023


  • Resumen Espectáculo
  • Leprosy is caused by Mycobacterium leprae, an alcohol-acid bacillus
    (ADR) with a predilection for skin and peripheral nerve cells. When
    in contact with the body, this bacillus can cause neurological dermato lesions and,
    therefore, physical, functional and psychological impairments. The high
    incidence of infection is related to ecological factors. From this perspective, studies
    make important advances in the conception of the natural history of
    diseases, as they contribute to the understanding of the dynamics of
    transmission of various pathologies, especially infectious diseases, such as
    leprosy. This research is part of the larger project "Susceptibility factors to
    leprosy in Alagoas: epidemiological, genetic and immuno-inflammatory aspects" and
    its primary objective is to analyze the sand-time epidemiological dynamics of
    leprosy in the state of Alagoas in the period 2010-2019 and identify factors of
    associated susceptibility and underreporting. To this do so, this retrospective study
    quantitative ecological nature involved confirmed cases of leprosy in the
    years from 2010 to 2019 that have obtained adequate records since the recognition of
    diagnostic form of the disease and the type of patient's entry into health services until the
    reported cases, which counted 4739 cases. These were obtained in the
    from October 2021 to February 2022 in the Injury Information System
    (SINAN) of the State Secretariat of Alagoas. Based on the
    Database of the Department of Informatics of the Brazilian Unified Health System
    (DATASUS). The analysis is being structured in five stages (descriptive, temporal,
    risk factors and underreporting) with the elaboration of tables, figures and graphs.
    Through temporal analysis, it was possible to infer that new cases of leprosy in
    population showed a decreasing trend (PCA/AAPC = - 3.0).
    However, for new cases of the population under 15 years of age, the disease
    presented a stationary trend which points out that the elimination of it in the
    state is more illusory than real. In addition, despite the
    physical disability in the diagnosis has a decreasing tendency, the indicator of
    2 of physical disability in the diagnosis is stationary. This given alert to
    a possibility of late diagnosis of the disease in the state of Alagoas. Still, it is worth
    point out that the indicator of degree of physical disability in healing that assesses the quality of
    attention and follow-up of new cases diagnosed until the completeness of the
    treatment- has a decreasing trend, which points to a fragility in the
    leprosy patients in the state. Still at this core, the indicator of
    grade 2 of physical disability in healing has a steady pattern. It is expected that
    this research is able to guide the identification of areas with greater vulnerability
    in Alagoas, as well as the definition of priority areas for tackling the
    leprosy. It is intended to produce and implement mechanisms to combat
    pathology and its complications.

9
  • NATHALY ESPERIDIAO DE MELO
  • Inflammatory status and levels of impulsivity and aggressiveness as risk factors for suicide

  • Líder : VALFRIDO LEAO DE MELO NETO
  • MIEMBROS DE LA BANCA :
  • VALFRIDO LEAO DE MELO NETO
  • ALYSSON WAGNER FERNANDES DUARTE
  • AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
  • FABIANA ANDREA MOURA
  • JULIANA CELIA DE FARIAS SANTOS
  • MARIA CICERA DOS SANTOS DE ALBUQUERQUE
  • Data: 14-jul-2023


  • Resumen Espectáculo
  • Introduction: Suicide and suicide-related behaviors represent a
    major global public health problem, with an estimated 800,000 deaths from
    suicide each year, making it one of the leading causes of death worldwide. Or
    suicidal behavior may result from the interaction of many risk factors. Evidence
    point out the relationship of some biological markers with the sharpening of the
    including the activation of immunoinflammatory pathways. Among other factors, they may
    impulsivity and aggressiveness should also be cited. Objectives: Analyze how traces of
    personality (aggressiveness and impulsivity) and inflammatory state may contribute to
    for suicidal behavior and scale the impact of brief telecalls on
    prevention of further suicide attempts. Methodology: Cases of suicide attempt
    were identified at the State General Hospital (HGE) and the study continued at the
    Professor Alberto Antunes (HUPAA/UFAL). The following were applied to the
    questionnaires: Socio-demographic and clinical questionnaire specific to the research; BIS-11
    (Barratt Impulsivity Scale) and AQ (Buss-Perry Aggressiveness Scale). The
    serum levels of inflammatory cytokines (IL-6, TNF-α, IL-8, IL-1β) will be quantified
    elisa technique. In parallel, patients were contacted by telephone or
    video call, in brief and regular contacts, with periodicity varying according to
    the distancing from the attempt. Results: So far eight
    Patients. Regarding the profile, half of the sample was male, and half of the sex
    female. Most were non-white ethnicity, marital status without a partner, with teaching
    incomplete fundamental and active occupational situation and had the unplanned attempt.
    The mean age of the sample ranged from 22 to 60 years of age. The other questionnaires
    high scores, showing a high degree of impulsiveness and/or aggressiveness
    in the sample studied. Conclusion: The data obtained up to the current moment of the search
    suggest that characteristics such as impulsive and aggressive personality traits increase
    the risk of suicide. The investigation of suicidal behavior, the sizing of the
    the problem and the analysis of its determinants, aims to encourage the adoption of more
    specific to the region studied in order to reduce the rates of death by suicide

10
  • GABRIELA BARBOSA AZEVEDO
  • Relationship between domestic violence and suicide attempt among women

  • Líder : VALFRIDO LEAO DE MELO NETO
  • MIEMBROS DE LA BANCA :
  • VALFRIDO LEAO DE MELO NETO
  • ALYSSON WAGNER FERNANDES DUARTE
  • JULIANA CELIA DE FARIAS SANTOS
  • MERCIA LAMENHA MEDEIROS
  • MARIA CICERA DOS SANTOS DE ALBUQUERQUE
  • VERONICA DE MEDEIROS ALVES
  • Data: 18-jul-2023


  • Resumen Espectáculo
  • Violence against women is a serious global public health problem, particularly in Brazil there
    are high and increasing cases of domestic aggression against women especially after the Covid
    Pandemic 19, from childhood to adulthood, this violence causes a series of physical changes
    and mental disorders that favor ideation and consequent suicide attempts. It is necessary to
    study the predisposing factors and symptoms more related to these attempts so that objective
    actions aimed at the impediment are taken and effected. Most suicide attempts are not even
    attended in health services and it is estimated that before the consumption of lethal fact a
    person performs previous attempts, in women the attempts are more frequent and this is
    justified by the use of less lethal methods, while men use more invasive and destructive
    methods, attempts can be prevented if well addressed, for this, in-depth data on factors
    involved are needed since the majority is not at least notified, a record that according to
    Ordinance No. 204 of the Ministry of Health should be done within 24 hours. This study seeks
    to understand and relate suicide attempts involving patients treated at the largest public
    emergency hospital in the state of Alagoas with domestic violence. Patients over 18 years of
    age treated in the emergency department with admission due to self-inflicted injury by suicide
    attempt will be interviewed, first a sociodemographic questionnaire and psychological pain
    scale, later the WAST scale validated for screening for domestic violence in women, patients
    who acentire will be followed at the University Hospital with psychiatric and psychological
    care, in addition, they will be monitored through teleservices performed by researchers
    weekly, every two weeks, monthly and quarterly. Between March and July 2022, 4 women
    were approached (50% of the total sample), all did not have a partner, all have children (2 to 3
    children) per woman and all have incomplete elementary school, 85% non-white, half inactive
    work, family income ranged from 400 to 2400 methods used were burn and injury by misplate,
    the mean age was 43.25 ranging from 24 to 60 years, one reported prior planning; the
    Psychological Pain scale showed a high degree of suffering indicated by high scores 44.75,
    higher than the general 43.85 [±8.68]. The data reveal the difficulties of screening, prevention
    and treatment of these women since none remained in the study, and it is not possible to
    apply the WAST questionnaire and subsequent follow-up.

11
  • GLAUCIO MAUREN DA SILVA GERONIMO
  • Cardiovascular risk and its correlation with inflammatory biomarkers in dialytic chronic kidney disease.
  • Líder : MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • MIEMBROS DE LA BANCA :
  • CARLOS ROMERIO COSTA FERRO
  • DANIELA MARTINS LESSA BARRETO
  • MERCIA LAMENHA MEDEIROS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • SAMIR BUAINAIN KASSAR
  • VALFRIDO LEAO DE MELO NETO
  • Data: 09-ago-2023


  • Resumen Espectáculo
  • INTRODUCTION: Patients undergoing hemodialysis (HD) have a cardiovascular risk (CVR) considerably higher than that of the general population, because these individuals end up presenting specific organic and inflammatory changes, in addition to lesions induced by substitutive therapy. In people with chronic kidney disease (CKD), there is also a pro-inflammatory state that contributes substantially to the occurrence of CV events and that induces an acceleration of atherosclerosis. OBJECTIVE: To analyze the CVR and its correlation with inflammatory markers in chronic renal dialysis patients. MATERIALS AND METHODS: This is a cross-sectional observational study, carried out in 3 tertiary hospitals, both public and private, with the application of socioeconomic and clinical questionnaires (gender, age, history, lifestyle habits), laboratory evaluation (hemogram , renal function, lipid profile, C-reactive protein – CRP, ferritin), measurement of inflammatory cytokines (Interleukin 6 – IL-6 and high tumor necrosis factor – TNFα) and measurement of cardiovascular risk score (assessment of global risk score – ERG). RESULTS: A total of 149 participants with CKD on renal replacement therapy (RRT), with a mean age of 58 ± 15 years, with 76 (64.4%) male participants. The adequacy of HD was measured through Kt/V, proving to be satisfactory in the sample. 81 (54.4%) were diabetic, 133 (89.3%) were hypertensive and 32 (21.5%) were obese. 36 participants were known to have heart disease, in addition to 8 others having already presented events resulting from significant obstruction. The CVR scores showed: 105 (70.5%) at high risk and 44 (29.5%) at very high risk.
12
  • EDER DA SILVA ROCHA SANTOS
  • Evaluation of leishmanicide activity of microorganism extracts isolated from the Caatinga biome.

  • Líder : ALINE CAVALCANTI DE QUEIROZ
  • MIEMBROS DE LA BANCA :
  • ALINE CAVALCANTI DE QUEIROZ
  • AMANDA EVELYN DA SILVA
  • CAROLINNE DE SALES MARQUES
  • FLAVIANA SANTOS WANDERLEY
  • JULIANA CELIA DE FARIAS SANTOS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • Data: 16-ago-2023


  • Resumen Espectáculo
  • Leishmaniasis is anthropozoonosis caused by protozoa of the genus Leishmania
    sp. and transmitted by vectors, mainly affect less-favored populations, where the
    access, medical care and drug therapy are limited, causing serious
    public health problems. For these reasons too,
    and are endemic in several countries. Clinical forms are varied, from
    simple skin lesions that may spontaneously disappear into the visceral form,
    affecting several organs, and may lead the individual to death. In Brazil, for all
    forms of leishmaniasis, first-line treatment is pentavalent antimonials
    Sb(V), currently the available antimonials are N-methyl-glucamina antimoniate
    (Glucantime) and sodium sybogluconate (Pentostan) for all forms of leishmaniasis,
    the first-line treatment are pentavalent antimonial Sb(V), currently the
    antimonial scans are N-methyl-glucamina antimoniate (Glucantime) and
    sodium sybogluconate (Pentostan), in addition to other second-choice drugs, however,
    cause a number of side effects and resistance on the part of patients. In view of this, the
    bioprospecting of natural products is an excellent alternative for
    production of new antiparasitium drugs, especially bioactive compounds of
    microorganisms, including bacterial ones. To this end, the present study aims to
    investigate the leishmanicide activity of extracts of microorganisms isolated from the biome
    Caatinga. To this do so, five bacterial isolates obtained from liquen samples were
    nutrient broth for seven days at 25 °C for biomass production. The
    intracellular pigmented metabolites were extracted with methanol and ethyl acetate,
    the extractive solutions obtained were dried in a vacuum desiccator.
    Subsequently, the cytotoxic activity against macrophages of the J774 scan was evaluated. A1
    using the MTT method. The anti-promastigote activity of
    Leishmania amazonensis and Leishmania chagasi, after cultivation of the parasite with the products
    Natural. It was found that the extracts did not present cytotoxic effect for macrophages.

13
  • CARLOS VIRGILIO ROCHA DE SOUSA SILVA
  • Sex Differentiation Disorders 46,XY: screening for pathogenic changes in a case series.

  • Líder : REGINALDO JOSE PETROLI
  • MIEMBROS DE LA BANCA :
  • Fernanda Caroline Soardi
  • DELIA MARIA DE MOURA LIMA HERRMANN
  • IRAMIRTON FIGUEREDO MOREIRA
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • REGINALDO JOSE PETROLI
  • Data: 28-ago-2023


  • Resumen Espectáculo
  • INTRODUCTION: Human sexual development is a process that depends on the integral functioning of several genes and their proteins. Defects in any of these components can cause sex differentiation disorders (DSD). DSDs are congenital conditions in which genetic changes lead to the atypical development of chromosomal, gonadal and/or anatomical sex. The term DDS, adopted from the Consensus Statement on Management of Intersex Disorders, replaces terms considered pejorative and stigmatizing, such as hermaphroditism, pseudohermaphroditism, among others. DSDs may result from variations in genes involved in sexual determination and differentiation, resulting in disorders in gonadal and/or adrenal steroidogenesis, being classified into three groups, according to the karyotype: DDS 46,XY; DDS 46,XX; and DSD associated with chromosomal abnormalities. The DDS 46,XY group, the focus of this work, is characterized by its genetic complexity and phenotypic overlap, where the etiological clarification of these cases is carried out through molecular investigation in genes involved in the determination and differentiation of sex. OBJECTIVE: To perform molecular investigation in a series of cases of 46,XY DSD with no clear etiology. METHODS: From a sample of 58 cases of DDS 46,XY treated at the Clinical Genetics Service of the Professor Alberto Antunes University Hospital (HUPAA), 10 cases were selected for study. For the selection of samples, the following criteria were adopted: previous sequencing of the AR and SRD5A2 genes, no pathogenic changes in these genes and DNA sample available for study. The first stage of the molecular investigation consisted of the sequencing of the HSD17B3 gene by the Sanger method, carried out at the Laboratory of Human Molecular Genetics of HUPAA/UFAL. The second stage, for those cases in which no pathogenic changes in the HSD17B3 gene were identified, the next-generation sequencing (NGS) of 18 genes related to DDS 46,XY, was performed at the Large-Scale Sequencing Center of the Medical School of the University of São Paulo. RESULTS AND DISCUSSION: No pathogenic alterations in the HSD17B3 gene were identified in any of the selected cases. Through the NGS, changes were identified in four cases. In the case of DDSXY-03, hemizygosis of c.89G>T (p.Arg30Ile) alteration in the SRY gene was identified; in the case of DDSXY-04, heterozygosis of the c.565C>T alteration (p.Arg189Cys) in the FKBP4 gene was identified; in the case of DDSXY-07, the heterozygosis of the c.2389C>G (p.Leu797Val) alteration in the DHX37 gene was identified; and in the case of DDSXY-10, the heterozygosis of the c.250C>G alteration (p.Arg84Gly) in the NR5A1 gene was identified. The p.Arg84Gly alteration has not been previously described in the literature, the p.Leu797Val has been described as a variant of uncertain significance, and the p.Arg189Cys alteration has been reported in databases, without reference to the associated clinical condition. The p.Arg30Ile alteration has been described in cases of 46,XY gonadal dysgenesis. In silic predictive analyses revealed that the p.Arg189Cys; p.Leu797Val and p.Arg84Gly are deleterious. According to the literature, the frequency of patients diagnosed with DSD 46,XY without clarified etiology can vary between 33%-80%, even with advances in diagnostic elucidation tools. CONCLUSION: In this study, 40% of the sample presented alterations in genes that are fundamental in the determination/differentiation of sex and remain under investigation of the possible genotype-phenotype correlation. Already 60% remain under investigation aiming at the identification of pathogenic alterations that may justify the phenotype. The functional analysis of the alterations identified here are necessary for the correct genotype and phenotype correlation in each case. The results of this study reinforce the complexity of the etiological elucidation of DSD 46,XY.

14
  • ANALICE SAMPAIO DE ALMEIDA BOMFIM
  • Epidemiological profile and clinical status of phenylketonurics in the State of Alagoas

  • Líder : SAMIR BUAINAIN KASSAR
  • MIEMBROS DE LA BANCA :
  • AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
  • GRACILIANO RAMOS ALENCAR DO NASCIMENTO
  • MERCIA LAMENHA MEDEIROS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • REGINALDO JOSE PETROLI
  • SAMIR BUAINAIN KASSAR
  • Data: 30-ago-2023


  • Resumen Espectáculo
  • Phenylketonuria or PKU is an ininate error of amino acid metabolism caused by the mutation of the gene encoding the liver enzyme phenylalanine hydroxylase. This enzymatic defect, related to autosomal recessive inheritance, leads to the accumulation of phenylalanine and its metabolic in the bloodstream and tissues that may imply neurotoxicity and cause irreversible cognitive and neurological damage, including mental retardation, when not diagnosed and treated early. Dietotherapy is the basis of the treatment of this aminoacidopathy and consists of a restrictive diet associated with the use of metabolic formula throughout life. This cross-sectional and observational study has, to date, a sample of 27 participants in follow-up to the Reference Service in Neonatal Screening (SRTN) of the State of Alagoas and aims to analyze the epidemiological profile and clinical situation of alagoan phenylketonurics. The variables surveyed were collected during a face-to-face interview through a questionnaire prepared by the executing researcher followed by physical examination and review of medical records. For the crossing between categorical variables, the chi-square test and fisher's exact test were used when necessary. The differences were considered statistically significant for p < than 5%. Preliminary results reveal that, of the 27 patients, 14 (51.83%) are children under 11 years of age, 70.40% male and 74.10% from the interior of Alagoas. All are single and only 3/27 have some paid activity. Only 29.60% have a family income above 2 minimum wages and 33% receive disease assistance because they have clinical complications and/or cognitive impairment. More than 80% reported clinical complications and 66.70% are classified as mild PKU. Adequate metabolic control was observed in only 22.20% of the study participants. Statistically significant associations were observed between the use of metabolic formula and the presence of clinical complications (p = 0.03) and between cognitive impairment associated with receiving social benefit p < 0.001. The shortage through the state program of acquisition and distribution of these formulas is considered by 74.10% the main factor that impairs the treatment and continuity of treatment. Finally, most alagoan phenylketonurics, although screened and assisted by SRTN/AL, suffer sequelae, avoidable, related to treatment conditions and have compromised health conditions.

15
  • VANNESSA RODRIGUES TELES MAIA
  • Antimicrobial and antioxidant profile of metabolites produced by filamentous fungi of the Caatinga biome

  • Líder : ALYSSON WAGNER FERNANDES DUARTE
  • MIEMBROS DE LA BANCA :
  • CAROLINNE DE SALES MARQUES
  • ANA PAULA DE ALMEIDA PORTELA DA SILVA
  • CAMILA SOUZA PORTO
  • ELOIZA LOPES DE LIRA TANABE
  • MICHEL RODRIGO ZAMBRANO PASSARINI
  • Data: 31-ago-2023


  • Resumen Espectáculo
  • The advent of antibiotics has revolutionized medical treatments, enabling the
    development of invasive and surgical techniques with feasibility of recovery and
    maintenance of the lives of individuals after the procedures, as well as the cure of diseases
    before fatal. Nevertheless, excessive and irregular use, in addition to genetic mechanisms
    developed by the microorganisms themselves, brought about microbial resistance,
    growing problem that has become a global concern in the 21st century, bringing to the fore the
    need for research for new antimicrobials. The search for new bioactive compounds
    antimicrobial and antioxidant activities from natural sources have great
    potential for application in human health. From this perspective, the Caatinga, because it is a biome
    exclusively Brazilian, with unique climatic characteristics, can host fungi
    producers of differentiated secondary metabolites. Thus, the objective was to evaluate the
    antimicrobial and antioxidant potential of secondary metabolites produced by fungi
    isolated filamentous liqueurs from the Caatinga of Alagoas. To this do so, 35
    fungi, produced in solid culture medium Czapek Agar supplemented with
    glucose 2% by incubation at 30 oC for 15 days. The extraction of secondary metabolites was
    performed in ethyl ACETATE PA, followed by concentration in rotary stirrer and drying in
    desiccator coupled to the vacuum pump, followed by production yield evaluation. The
    extracts were resuspended in DMSO (100 mg/mL) and initially evaluated the
    antibacterial and antifungal activities by disc diffusion and antioxidant assay by
    FRAP and DDPH. The next steps will be the assessment of Minimum Injunction Concentrations
    (MIC) of extracts with antimicrobial activity, in addition to the analysis of the effect of metabolites
    antimicrobials in biofilms of Staphylococcus aureus and Candida albicans, by means of
    cell viability test at different concentrations of extracts, as well as by
    scanning optical microscopy. As partial results, the yield of the extracts
    ranged from 45.00 mg to 173.00 mg, and the extracts showed different
    colors such as 15 yellows, seven oranges and two roses. The fungal extract 3UVLFC1
    antimicrobial activity against Staphylococcus aureus, while the samples
    Penicillium sp. (2LCL1), Fusarium sp. (4LCEM2) and 4UVLFC2 demonstrated
    against Candida abicans. Regarding antioxidant activity, the following samples showed
    activity identified by frap and DPPH methods: 2LCL1, 4UVLFC2, 3UVLFC7,
    4LCEM2, 7UVLFC2, 4UVLFC7, PLC6, Fusarium sp. (ALC3), 1UVLFC7 while the samples
    then revealed antioxidant activity by frap method: GLC5 and 2UVC8. It can be insated that
    the fungi isolated from Caatinga liquens have antioxidant potential and
    which indicates the possibility of biotechnological application.

16
  • AMANDA ALVES FEITOSA BATISTA
  •  

    Genetic assessment and surgical treatment of non-syndromic oral clefts in the Brazilian Unified Health System: a multicenter analysis.

  • Líder : ISABELLA LOPES MONLLEO
  • MIEMBROS DE LA BANCA :
  • VERÔNICA OLIVEIDA DIAS
  • DEBORA DE PAULA MICHELATTO
  • DÉBORA GUSMÃO MELO
  • ISABELLA LOPES MONLLEO
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • RAFAELA SCARIOT
  • Data: 31-ago-2023


  • Resumen Espectáculo
  • Background: Oral clefts are complex and frequent congenital anomalies. The frequency of dysmorphic signs associated varies from 3% to 63%. The presence of dysmorphic features may change the status from non-syndromic OC (NSOC) to syndromic OC. The diagnosis established through genetic assessment allows treatment planning accordingly to the patient needs and genetic counseling. Treatment is longitudinal and multidisciplinary throughout the health system levels. Timely primary surgery (cheiloplasty and palatoplasty) is essential for successful rehabilitation. A network of 30 craniofacial hospitals accredited by the the Ministry of Health (CFAH) provides specialized treatment in Brazil. However, throughout the country, non-CFAH also operate to the supply-demand disequilibrium. Aim: To investigate the access of patients with NSOC to genetic assessment and surgery in CFAH and non-CFAH. Methods: Quantitative, retrospective, observational, multicenter study with patients with FONS, followed-up from 2008 until 2019 in two CFAH and two non-CFAH members of Brazil's Craniofacial Project. Data was collected during outpatient visits using the CranFlow platform that feeds the Brazilian Database on Craniofacial Anomalies (BDCA). Genetic assessment and cheiloplasty performed after 12 months-old and palatoplasty after 18 months-old were classified as delayed. Odds ratio (OR), Chi-square and Fisher's exact tests were used for statistics with a p-value of 0,05 for significance.  Results: Information on 840 patients with NOC feeded the BDCA after genetic assessment. The CFAH and non-CFAH patient rate was 2:1, with the majority attending hospitals in the Northeast of Brazil. Age ranged from 1 day to 61 years-old (4±8) with a predominance of children up to 12 months old. Most lived outside the city where the hospital is located, had low-income families and parents with low education. Cleft lip and palate (CLP) occurred in 54.1%, cleft lip (CL) in 25.4%, and cleft palate (CP) in 20.5% of cases. CLP predominated in males and CP in females (p<0.00); unilateral over bilateral clefts (p<0.00), and left-sided over right-sided clefts (p<0.00). The first genetic assessment was performed before completing 12 months-age in 53.1% of the sample. When comparing patients who had timely genetic assessment with late assessment, there was an increased odds of patients in the delayed group experiencing the following barriers: attending a Non-CFAH (OR=1.8; p<0.000), living outside the hospital's location (OR=1.40; p=0.032) and having illiterate mother (OR=11.72; p<0.000) and father (OR= 3.67; p<0.000). Due to the lack of information on the status of surgical treatment in the BDCA, 331 (39.4%) patients were excluded from this analysis. Among the remaining 509, 261 (51.3%) have had surgical delay, 170 had been timely repaired and 78 were into the time-window for surgery. Summing up there were 431 patients timely-repaired, late repaired and late non-repaired for whom 666 surgeries were needed. However, 418 surgeries were overdue, 219 of which were palatoplasties. When comparing patients who had timely surgery with late surgery, there was an increased odds of patients in the delayed group experiencing the following barriers: attending a Non-CFAH (OR=2.7; p<0.000) from the Northeast (OR=3.93; p<0.000), being in a low-income family (OR=2.32; p=0.005), and having parents with low education (mother: OR=15.11; p<0.000; father: OR=3.53; p=0.001). There was a statistically significant increased odds of patients who needed palatoplasty compared to those who needed cheiloplasty (OR=1.8; p<0.000). Conclusion: Clinical-genetics characteristics of the sample corroborate the literature on the epidemiology of NSOC around the world. Overall, half of the patients included in this study had a delay in genetic assessment and/or surgical rehabilitation. Differences were found in the access of patients with NSOC to genetic assessment and surgery, with a greater disadvantage for those followed at NCFH and needing palatoplasty. Patients with NSOC experienced many barriers to access genetic assessment and surgery through the Brazilian Unified Health System. These results highlight and strengthen the need to establish a transversal health policy, having the CFAH as a reference network able to address the unmet health needs of this population.

17
  • CIANE DE JESUS GOMES VIEIRA
  • Level of Physical Activity associated with Asthma, Rhinitis and Eczema in Adolescents in Maceió.

  • Líder : MERCIA LAMENHA MEDEIROS
  • MIEMBROS DE LA BANCA :
  • AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
  • FLAVIO TELES DE FARIAS FILHO
  • JULIANA CELIA DE FARIAS SANTOS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • NATALIA DE ALMEIDA RODRIGUES
  • VALFRIDO LEAO DE MELO NETO
  • Data: 26-oct-2023


  • Resumen Espectáculo
  • Introduction: The prevalence of allergic diseases has demonstrated a continuous
    growth in recent years (FERREIRA et al., 2021). It is observed that changes in
    environments and lifestyles, foster the rise of adolescents with
    chronic diseases such as obesity, hypercholesterolemia, diabetes and may be associated with
    with asthma, rinitis and atopic dermatitis. The impacts on the physical health of adolescents are not
    should be the only ones to observe, because the routine and quality of life of these patients
    are very affected (HATHERILL, 2007), making it difficult for them to be participated in
    physical activity, not decreasing sedentary behaviors (BLACKMAN;
    CONAWAY, 2012; chamlin, 2010. CHREN, 2010; SHIN; CHO, 2012; KIM; LEE;
    RIESCHE, 2020). Objectives: To know the level of physical activity, behavior
    mental disorders and their association with asthma, rinitis and atopic eczema in patients with
    adolescents. Methodology: This is a cross-sectional study, through the application of
    written questionnaires (QE) translated and validated. Adolescents were evaluated,
    public and private schools, based on the proportion of enrolled. Inclusion criteria
    in the research were literate adolescents who had cognitive conditions to
    answer the questionnaires. Exclusion criteria were the correct non-completion
    questionnaire or if it is incomplete, and those with
    cardiorespiratory and dermatological conditions. Results: The initial sample was composed of
    821 adolescents, 380 (47.3%) boys and 423 (52.6%) girls, 662 of which were
    (80.6%) from the public network and 159 (19.3%) privately. The prevalence of adolescents with
    Common Mental Disorders (CMD) was 548 (75.3%), with 311 (83.8%) of girls
    and 220 (64.9%) of the boys with CMD (p of 0.00). We infer that 428 (73.4%)
    of public school adolescents and 120 (83.3%) of private adolescents had CMD,
    demonstrating that being from private school is a risk factor for the presence of CMD
    (PR: 1.13; CI 1.03 - 1.23; p< 0.01). We saw that 178 (83.9%) from class A to B1 and 370
    (72.1%) of classes B2 to E had some type of CMD, and the level of
    schooling and CMD, 331 (76.4%), had completed high school to higher education
    Complete, and 185 (74.9%) from illiterate to Incomplete High School. In diseases
    the prevalence of asthma in adolescents was 145 (18.3%), allergic rhinitis
    278 (36.3%), and Eczema 78 (87.6%). Of the adolescents with asthma, 120 (90.2%)
    presented CMD, demonstrating that those with Asthma may be more likely to

    for the development of mental disorders (PR: 1.24; CI 1.15 - 1.34; p< 0.01). Of
    adolescents with Rinitis, 214 (84.9%), and 97 (12.8%) with Eczema, showed CMD. The
    prevalence of the level of physical activity (NAF) in adolescents was 321 (39.6%) students
    145 (34.6%) of girls reaching 180 minutes per week and 273 (65.3%)
    below ideal, and among boys, 170 (45.4%) reached the recommendations and 204
    (54.5%) stated that they were not active. The NAF of adolescents related to CMDs is not
    was so significant (PR: 1.01; CI 0.93 - 1.11; p of 0.65). In asthmatic adolescents, 64
    (20.7%) were active and 76 (16.1%) in sedentary behavior, in rinitis 112 (34.4)
    and 162 (35.6%) in sedentary behavior, and with Eczema 57 (59.3%) are
    39 (40.6%) reach the ideal weekly duration. About screen time,
    343 (79.0%) of the adolescents exposed for more than 3 hours on the screens, reported having
    CMD, as well as 525 (98.5%) of adolescents who use social networks, expressed
    signs and symptoms of CMD. Conclusion: rinitis showed a higher prevalence among
    allergic diseases, as well as sedentary behaviour and mental disorders
    asthma, rinitis and eczema were identified in adolescents who identified them.

18
  • CAMILA MAIA COSTA DE QUEIROZ SOUTO
  • Clinical and molecular characterization of families with Congenital Adrenal Hyperplasia in the Brazilian Unified Health System of Alagoas

  • Líder : REGINALDO JOSE PETROLI
  • MIEMBROS DE LA BANCA :
  • AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
  • Fernanda Caroline Soardi
  • IRAMIRTON FIGUEREDO MOREIRA
  • JOSE ROBERTO DE OLIVEIRA FERREIRA
  • JULIANA CELIA DE FARIAS SANTOS
  • REGINALDO JOSE PETROLI
  • Data: 14-nov-2023


  • Resumen Espectáculo
  • Introduction: Congenital Adrenal Hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is an inborn error of autosomal recessive metabolism. The clinical form depends on the 21OH residual enzymatic activity. The classic salt-wasting form (CL-PS) causes homeostatic imbalance, leading to death in the neonatal period if not identified and treated in time. HAC-21OHD was incorporated into the National Neonatal Screening Program (PNTN) in Brazil in 2012 and implemented in the Brazilian Unified Health System of Alagoas (SUS-AL) in 2016 and the screened patients are referred to a multidisciplinary team at the reference service of neonatal screening (Serviço de Referência em Triagem Neonatal – SRTN), linked to the Santa Monica Maternity Hospital of the Health Sciences State University of Alagoas (SRTN/MESM/UNCISAL). Before the PNTN, since 2008, CAH patients from SUS-AL have been followed up at the Clinical Genetics Service of the Professor Alberto Antunes University Hospital of the Federal University of Alagoas (SGC/HUPAA/UFAL). Both services are a reference in the care of patients with HAC-21OHD in SUS-AL. Objective: To describe the clinical-molecular profile of HAC-21OHD in SUS-AL, based on the composition of a unique database. Methods: Patients treated from 03/2008 to 02/2022 in both services, with HAC-21OHD clinical and laboratory diagnosis, were included. Data were collected from medical files and molecular reports of CYP21A2 gene analysis. Case series descriptive analysis was performed, with frequency distribution and measures of central tendency and dispersion. Results: The unique database consisted of 45 patients distributed in 40 families, most from the interior of AL (71,1%), and 17,5% reported consanguinity. The age at the 1st consultation ranged from 7 days to 43 years old and 68,2% had genital ambiguity. The CL-PS form was the most frequent, with the c.290-13A/C>G variant being the most prevalent, followed by p.Ser170Lisfs*125. Four patients died from adrenal crisis, one of them, screened by the PNTN, died before the results were published. Conclusion: The data presented here are in accordance with the literature, where the CL-PS form is more frequent, with a higher prevalence of the c.290-13A/C>G variant. However, the high frequency of the p.Ser170Lisfs*125 variant, considered rare, provides evidence of a possible founder effect. The need for decentralization of services to the interior of the state is evident. Deaths from the adrenal crisis have substantially reduced, but there is still a need to improve the flow of service. The recognition of these characteristics is important both at the individual and at the collective level, supporting the construction of specific health policies for these patients.

19
  • BRENDA ALEXIA DE LIMA THEODOSIO
  • Interrelationship of nutritional profile, risk of sarcopenia, functional capacity and inflammation in chronic kidney disease

  • Líder : MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • MIEMBROS DE LA BANCA :
  • ALESSANDRA PLACIDO LIMA LEITE
  • ANTONIO FILIPE PEREIRA CAETANO
  • AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
  • FABIANA ANDREA MOURA
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • VALFRIDO LEAO DE MELO NETO
  • Data: 19-dic-2023


  • Resumen Espectáculo
  • Chronic kidney disease (CKD) is a condition in which progressive loss of kidney function occurs, leading to complications and impacting patients' quality of life. The global increase in the number of CKD cases has led to an increase in hemodialysis (HD). However, HD is associated with complications such as nutritional disorders and chronic inflammation. Knowing this, the present study aimed to evaluate the interrelationship between the nutritional profile, risk of sarcopenia, functional capacity and inflammation, in order to identify groups of patients most vulnerable to these associations. This is a cross-sectional study that was conducted with patients on hemodialysis in the nephrology centers of Hospital Veredas, UNIRIM of Hospital Memorial Arthur Ramos and UNIRIM of Hospital do Coração. The work was divided into three stages, being: 1st application of socioeconomic questionnaires and data collection in medical records; 2nd nutritional assessment, including anthropometry and tests to assess functional capacity; 3rd blood collection and measurement of inflammatory cytokines. The initial sample consisted of 148 participants, most of whom were adults (52.7%) and the remaining elderly, with mean ages of approximately 46.6 years and 70.45 years, respectively. Regarding BMI, 41.7% of the participants were overweight, while 16.7% were underweight. Low strength was observed in 9% of the sample and low velocity in 16.8%. The risk of SARC-F sarcopenia was observed in 31% of participants, while SARC-f+CC was observed in 33%. The inflammatory parameters IL-6 and TNF-α were detected in 82.3% and 49.6% of the participants, respectively. Dialysis was considered inadequate in 19.4% of the participants. The mean Kt/V was better in adults compared to the elderly. It was observed that low weight (n=4; 23.5%) and eutrophy (n=10; 58.8%) presented worse gait speed than overweight patients (n=3; 17.7%). The risk of SARC-F sarcopenia was the same in overweight patients (n=9; 47.4%) and in patients with eutrophy (n=9; 47.4%), while underweight patients only represented 5.2% (n=1). When using SARC-F+CC, more eutrophic patients were classified as at risk (n=16; 53.3%), followed by overweight (n=16; 33.3%), and underweight (n=4; 13.4%). These findings may help in the formulation of more targeted and effective therapeutic strategies to care for this group of patients.

2022
Disertaciones
1
  • ANTONIO FILIPE PEREIRA CAETANO
  • Physical Activity, Quality of Life and Nutritional Profile in Chronic Renal Patients

  • Líder : JULIANA CELIA DE FARIAS SANTOS
  • MIEMBROS DE LA BANCA :
  • JULIANA CELIA DE FARIAS SANTOS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • VALFRIDO LEAO DE MELO NETO
  • BRAULIO CESAR DE ALCANTARA MENDONCA
  • SAMARA BOMFIM GOMES CAMPOS
  • Data: 03-feb-2022


  • Resumen Espectáculo
  • INTRODUCTION: Chronic Kidney Disease (CKD) is sustained damage to the renal parenchyma causing deterioration and progressive loss of kidney function that may progress to the end stage. Some studies have shown beneficial results for the practice of physical exercise in the treatment adjunct to various pathologies, especially for metabolic diseases such as obesity, dyslipidemia and diabetes mellitus; and for cardiovascular diseases and Systemic Arterial Hypertension, pathologies that are bases or metabolic alterations associated with the development of CKD. Such benefits can also be observed in aspects of quality of life, especially those focused on emotional, psychosocial and general perception of well-being. OBJECTIVE: To evaluate the level of physical activity, quality of life and nutritional profile; associate and correlate the levels of physical activity, nutritional profile and quality of life level with ckD stages of patients undergoing conservative treatment for Chronic Kidney Disease in a high complexity hospital in a capital of northeastern Brazil. MATERIALS AND METHODS: Observational study and cross-sectional study. The sample was selected by convenience, formed by all patients with CKD assisted by nephrology outpatient clinics (CIN-HUPAA). Patients of both sexes were studied; over 18 years of age; signed the Free Consent and Informed Consent Form (TCLE). The analysis variables were: socioeconomic and outpatient data; nutritional profile data (Body Mass Index, Waist Circumference and Fat Percentage); level of physical activity (from the application of the International Physical Activity Questionnaire, IPAQ-Short Version); quality of life (from the World Health of Quality of Live (WHOQOL-Bref)). All analyses were performed with the aid of software R, with the jasp statistical package version 0.13.1, adopting a confidence level of 95% (p<0.05). The Shapiro-Wilk Test was used to verify the normality of the data. For the association between the variables, the Mann Whitney was used; as well as the R-Spearman correlation was used for the monotonic variables (continuous or ordinal) of the variables QOL, NAF and BMI and GFR. The size of the effect based on D-Cohen's Standardt having as reference 0-0.2 for irrelevant effect; 0.3-0.5 for small effect; 0.6-0.8 average effect; above 0.9 wide effect. Significance levels were considered p= <0.05 and confidence interval at 95%. RESULTS: Fifty-two patients with a mean age of 60.3 years ± 9.11 years participated in the study. Within the social profile and general health aspects were patients 53.84% women, 88.46% mixed color, 63.49% resident in Maceió, 42.3% single, 34.61% with incomplete elementary school, 57.69% with Diabetes Mellitus Type 2, 76.92% with Systemic Arterial Hypertension, 13.47% with dyslipidemia; 86.53% non-smokers and 78.84% non-smokers. Nutritional Profile: 76.73±5.31Kg; 38.46% were obese and 61.53% eutrophic or overweight; 82.69% with elvados DC standards; 15.34±5.02 %G (eutrophic). Level of physical activity: 38% are insufficiently active and 29% sedentary, a sample with low levels of physical activity. Quality of Life level: lower scores in satisfaction with health (2.98± 0.83) and environment (2.75± 0.38); better scores in the psychological domain (3.80± 0.53) and Social Relations (3.58± 0.58), but the sample presents regular levels of perception with quality of life. Only health satisfaction (p=0.043) and BMI (p=0.034) showed a significant difference in the association between ckd stages of patients with levels of physical activity, nutritional profile and quality of life level. The correlation was negative of the CKD stage only with the social relations dimension (0.084) of the quality of life level, but the other variables showed positive correlations. CONCLUSIONS: The subjects presented low levels of physical activity, but these levels did not change in association with ckD stages, but the higher the CKD stage, the lower the levels of physical activity practices recommended by the WHO. Regarding the perception of quality of life, the patients evaluated presented low levels, especially in the context of health satisfaction. The subjects undergoing conservative treatment with GFR < 59ml min revealed lower scores, even though the associations between the groups did not present significant differences. The greatest impact on the stages in the correlation was observed in social relations.

2
  • AMANDA LIRA DOS SANTOS LEITE
  • Analysis of pain control of patients submitted to pectoral block (PEC) in radical mastectomies with axillary approach in an oncological hospital in Maceió

  • Líder : CAROLINNE DE SALES MARQUES
  • MIEMBROS DE LA BANCA :
  • ALESSANDRA PLACIDO LIMA LEITE
  • AMANDA KARINE BARROS FERREIRA RODRIGUES
  • CARLOS ALBERTO DE CARVALHO FRAGA
  • CAROLINNE DE SALES MARQUES
  • FREDERICO THEOBALDO RAMOS ROCHA
  • Data: 21-mar-2022


  • Resumen Espectáculo
  • Introduction: Patients submitted to mastectomies with axillary dissection suffer greatly from postoperative pain and discomfort, so we sought to study regional blockade techniques that could minimize this effect, such as interpecal block (PEC). This technique may become an analgesic option widely used in axillary surgery due to the low rate of complications and the characteristic technique of single puncture that allows simultaneous blockade of several dermatomes, probably reducing postoperative pain and reducing the abusive use of opioids and their complications. Objectives: To evaluate the efficacy of pec anesthetic block alone when compared to the use of intravenous analgesics in the postoperative period of radical mastectomy, to evaluate complications from opioids and PEC block, to analyze the average consumption of opioids within 24 hours and cost-benefit of performing the blockade. Methodology: Randomized, controlled clinical trial with 78 patients with breast cancer who underwent mastectomy with axillary approach. Randomized 2 groups, one control, with exclusive general anesthesia and another group that received general anesthesia and PEC block with Levobupivacaine/Ropivacaine (infiltration of 10 ml between pectoral muscles and 20 ml between the pectoralis minor and serrátil), guided by intraoperative ultrasound. Prescription of Novalgina, Tramadol and morphine if necessary were offered post-surgery. In 24 hours postoperatively, a questionnaire was applied with the EVA pain scale and the statistical analysis of data used the Shapiro-Wilk test to assess the normality of the data, and the Mann-Whitney test for comparison between the groups. Chi-square was used to compare proportions. The data were analyzed by sigmaplot software 12. Results: Pain was observed, according to the VAS scale, on average, lower in the group with PEC (1.08) than in the group without PEC (1.56). This difference, however, was not statistically significant (p = 0.186). The percentage of participants who used analgesics in the group with PEC (45.9%, 17/37) was lower than the percentage of patients in the group without PEC (58.5%, 24/41), but without statistical significance (p = 0.2689). The percentage of those who used opioids in the groups with PEC (18.92%, 7/37) and without PEC (23.80%, 10/41) was equivalent (p = 0.6026), although higher in the group without PEC. The total amount of opioid consumed in the group without PEC was higher (1010 mg) than in the group with PEC (620 mg), but comparison of mean use was equivalent (p = 0.454). There was a low rate of complications such as PONV in both groups. Conclusion: Pec blockade showed a slight improvement in the quality of analgesia, reduced analgesic consumption after surgery in breast cancer, and presented a low rate of complications, and may be a first-line option for analgesia in breast surgeries, however, it was not possible to prove its superiority in the control of postoperative pain over the course of 24 hours in relation to exclusive intravenous analgesia used intraoperatively.

3
  • SERGIO LOPES DA SILVA
  • INFLUENCE OF SCHWANN CELLS ON THE PROGRESSION OF PROSTATE CANCER

  • Líder : CARLOS ALBERTO DE CARVALHO FRAGA
  • MIEMBROS DE LA BANCA :
  • ALINE CAVALCANTI DE QUEIROZ
  • AMANDA KARINE BARROS FERREIRA RODRIGUES
  • BRUNA DEL VECHIO KOIKE
  • CARLOS ALBERTO DE CARVALHO FRAGA
  • CAROLINNE DE SALES MARQUES
  • JUSSARA ALMEIDA DE OLIVEIRA BAGGIO
  • Data: 31-mar-2022


  • Resumen Espectáculo
  • The phenomenon of carcinogenesis is a complex process that occurs through multiple genetic events that alter the normal functions of oncogenes and tumor suppressor genes. Studies have shown that Schwann cells participate in the tumor microenvironment, producing several factors that benefit cancer cells. During this process, Schwann cells are undifferentiated and aid the process of cancer cell proliferation. These cells then migrate to the region near the tumor tissue and aid the development of the neoplastic cell. In this context, the aim of this study was to evaluate the influence of Schwann cells on prostate cancer. We performed a bioinformatics view and observed that the "neuroactive connecting-receptor interaction" was positively regulated in prostate cancer. The "p53 signaling pathway" is active, since CCNE1, CDKN2A and PERP are increased. specific miRNAs inactivate the pathway of "guidance of axons", aiming at the ROBO2 and SLIT2 genes. Both genes are also associated with inhibition of schwann cell migration. In addition, GFAP and GAP43 are overexpressed, leading to dedifferentiation of Schwann cells. Both Schwann and neoplastic cells are stimulated via phosphorylation cascade to proliferate and migrate. The results show that schwann cell dedifferentiation and proliferation are induced by neoplastic tissue; consequently, Schwann cells produce different factors that will participate in various tumor progression processes. These processes may also be involved in tumor invasion in perineural tissue in prostate neoplasia.

4
  • ELISA ESTEVES ROSSINI
  • Association study between Childhood Adversity and Inflammatory Markers in Patients with Systemic Lupus Erytheamus.

  • Líder : MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • MIEMBROS DE LA BANCA :
  • WILLIAM BERGER
  • ALINE CAVALCANTI DE QUEIROZ
  • ANDRÈ BARCIELA VERAS
  • FLAVIO TELES DE FARIAS FILHO
  • JULIANA CELIA DE FARIAS SANTOS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • Data: 27-abr-2022


  • Resumen Espectáculo
  • Systemic Lupus Erytheatosus (SLE) is a chronic inflammatory disease that affects connective tissue. Of multifactorial etiology, it infringes several organs and systems, simultaneously or alone, with multivariate clinical manifestations, at any stage of the pathology. Among these alterations, we highlight the increase in inflammatory markers, such as IL-6. Adversities in childhood cause neuropsychological damage during the development of the child's central nervous system, as well as the chronic increase in inflammatory markers. This research is a descriptive cross-sectional study with quantitative methodology, with the objective of studying the association between the inflammatory marker IL-6 and adversities in childhood, in women with systemic lupus erytheama treated at the rheumatology outpatient clinic of the University Hospital Prof. Alberto Antunes (HUPAA) of the Federal University of Alagoas, in the city of Maceió. To this end, after signing the free and informed consent form, the hiv-6 IL of these patients should be quantified, as well as the Childhood Trauma Questionnaire, an assessment tool for adolescents and adults, which investigates a history of abuse and neglect during childhood. At the end, the results will be evaluated through the Statistical Package SPSS - version 23. It is noteworthy that all stages of the study should carefully follow the guidelines of resolution 466/12 of the National Health Council.

5
  • FELIPE CAMILO SANTIAGO VELOSO
  • Preparation of a neonatal death prediction score using Data from SINASC and
    SIM of the State of Alagoas between 2016 and 2020: a case-control study.

  • Líder : SAMIR BUAINAIN KASSAR
  • MIEMBROS DE LA BANCA :
  • ALYSSON WAGNER FERNANDES DUARTE
  • AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
  • MERCIA LAMENHA MEDEIROS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • RICARDO QUEROZ GURGEL
  • SAMIR BUAINAIN KASSAR
  • Data: 27-abr-2022


  • Resumen Espectáculo
  • Context. Being born in Brazil is a challenge. In 2019, approximately 24,000 neonatal deaths
    were registered in the country. There are almost three deaths per hour in the country, something worrisome and that
    needs attention. Health professionals have several tools to assist in
    prediction of this outcome. However, such tools are mostly based on
    in-hospital aspects, focused on the points of intensive care, and based on
    data from developed countries. Goal. Develop a neonatal death prediction score
    using data present in the declarations of live birth and death of the State of Alagoas
    between 2016 and 2020. Methods. This is a case-control study, which
    involved newborns whose death occurred between birth and 27 full days of life
    (case) and surviving newborns at the same period (control). Data collection was
    held at the Health Surveillance Superintendence of the Health Department of the State of
    between December 2020 and February 2021. The sample size
    based on the absolute number of neonatal deaths between 2016 and 2020. The variable
    dependent was neonatal death. The independent variables corresponded to the
    present in the DAndd. The statistical analysis included descriptive analysis of the data, as well as
    bivariate and multivariate analysis, in addition to sensitivity, specificity and
    construction of the ROC curve. Findings. There were 1,338 neonatal deaths between 2016 and
    2020 in Alagoas. The weight < 2500 g obtained an adjusted OR of 7.52 (5.86 – 9.74); the presence
    congenital malformation 28.15 (16.73 - 47.36); gestational age < 37 weeks 6.06 (4.72
    – 7.78), APGAR < 7 in the 5th minute 61.61 (38.01 - 99.88) and prenatal care with < 7 consultations 1.29
    (1.04 – 1.59). The VK-10 score, whose best cut-off point found was greater than or equal to five,
    obtained an AUC of 89.6%, in addition to a sensitivity of 72.28%, a specificity of
    95.61%, a positive likelihood ratio of 16.46 and a likelihood ratio
    negative of 0.28. Conclusion. The VK-10 score is shown as a proposal to be valued,
    once it presented a high AUC. Moreover, because it has a reason for likelihood
    positive high, a score above five points should be valued, that is, when there is a
    higher chance of death.

6
  • RITA MARCIA PACHECO LINS
  • Association between suicide risk and plasma levels of Interleukin-6 in patients with Systemic Lupus Erythemitatosus

  • Líder : VALFRIDO LEAO DE MELO NETO
  • MIEMBROS DE LA BANCA :
  • LUCAS ARAUJO DE FREITAS
  • CLAUDIO TORRES DE MIRANDA
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • SHEILA CAVALCANTE CAETANO
  • TIAGO GOMES DE ANDRADE
  • VALFRIDO LEAO DE MELO NETO
  • Data: 27-abr-2022


  • Resumen Espectáculo
  • Introduction: Suicidal behaviors constitute a global health burden and lead to the annual death of 1 million people worldwide. Populations with depression and suicide risk have high il-6 levels. Patients with Systemic Lupus Erytheatosus (SLE) have a prevalence of psychiatric manifestations between 10 and 80%. Objective: To investigate the risk of suicide in patients with SLE and the association with plasma levels of the biomarker- Interleukin-6. Material and Methods: Cross-sectional study, convenience sample of women diagnosed with SLE and attended at the Professor Alberto Antunes University Hospital of the Federal University of Alagoas. Data were collected using the assessment instruments: Mini International Neuropsychiatric Interview v.5.0.0, Beck Depression Inventory, Beck Hopelessness Scale, Pittsburgh Sleep Quality Index, Short-Form-36 form and peripheral blood collection for IL-6 biomarker analysis through ELISA through cytokine kits (Biosciences®). The data was transferred to the SPSS program for Windows version 23 (SPSS Inc. Chicago, IL). The Shapiro-Wilk Test was used to assess the normality of the variables, the distribution of the sample was non-normal, the mean scans between the groups were performed by the Mann-Whitney test. For the analysis of the association of dichotomous variables, a Chi-square test was performed and the odds ratio calculation (odds-ratio), 95% confidence interval and statistical significance established in 5% (p<0.05) were generated. Preliminary results: The sample consisted of 45 women, mean age 36.57 (±9.47 years. Of these, 31.1% had Major Depressive Episode (MD) and 53.3% had at least one anxiety disorder. Patients with MDD presented suicide risk 14.5 times higher than non-depressed patients, in addition to worsening sleep quality and greater impairment in quality of life in several domains of the SF-36. Interleukin-6 biomarker analysis has not yet been performed. Conclusion: The prevalence of depression was higher than that described in the general population. The risk of suicide was associated with higher severity of depressive symptoms and hopelessness and worse scores of quality of life and quality of sleep.

7
  • LIVIA MARIA BORGES AMARAL TENORIO
  • Inflammation and risk of sarcopenia in diabetic individuals with chronic kidney disease during the COVID pandemic 19.

  • Líder : JULIANA CELIA DE FARIAS SANTOS
  • MIEMBROS DE LA BANCA :
  • BRAULIO CESAR DE ALCANTARA MENDONCA
  • FABIANA ANDREA MOURA
  • FLAVIO TELES DE FARIAS FILHO
  • JULIANA CELIA DE FARIAS SANTOS
  • SAMIR BUAINAIN KASSAR
  • Data: 28-abr-2022


  • Resumen Espectáculo
  • INTRODUCTION: Diabetic nephropathy is the main complication that leads diabetic patients to hemodialysis. At this time of pandemic by COVID 19, patients with diabetes, especially the obese diabetics, are part of the risk group that can evolve with the most severe presentation of the disease. In obese individuals with diabetes and patients with chronic kidney disease, the inflammatory process occurs in an exacerbated manner with the uncontrolled elevation of inflammatory cytokines and may have an unfavorable outcome. The sarcopenia present in these patients also appears as a complicating factor during the pandemic period, with repercussions still uncertain in this scenario. OBJECTIVE: To investigate the risk of sarcopenia and inflammatory response in diabetic patients with chronic kidney disease, underconservative treatment during the COVID pandemic 19. MATERIALS AND METHODS: The dissertation presents two products. Product 1 is a review article "Metabolic pathways and hyperinflammation in covid 19 in chronic renal diabetic obese patients and their post-infection physical rehabilitation", published in the Journal of Development ISSN: 2525-8761, DOI: https://doi.org/10.34117/bjdv7n7-167. The second product refers to a cross-sectional study, observational, and the sample was calculated from 40 diabetic patients undergoing conservative treatment for Chronic Kidney Disease (CKD), with < 60mL/min/1.73m² (GFR calculated with ckd-EPI formula) of both sexes, assisted by the Integrated Nephrology Center of the Professor Alberto Antunes University Hospital (HUPAA) during the COVID pandemic 19. The collection was carried out from January to July 2021. The study was done in two stages, the first being retrospective observational by collecting data from medical records, including socioeconomic, anthropometric (weight and height) and biochemical data (blood count, urea, creatinine, albumin, fasting glycemia, lipidogram, C-reactive protein, ferritin, uric acid, sodium, potassium, calcium, phosphorus, PTH and 25-hydroxy-vitamin D). The second part was the collection of blood samples for the evaluation of inflammatory cytokines (IL-1β, IL-6, IL-8, TGF-β) and screening of sarcopenia by applying the SARC-F<® questionnaire. RESULTS: Forty-one patients (63.8% elderly and 36.1% adults) were evaluated, and a high percentage of obesity was observed (mean BMI 30.4Kg/m², with SD 6.541, p 0.001), with 39.02% of obese individuals and the presence of a decreased glomerular filtration rate (mean GFR of 38.2mL/min/1.73m², with SD 14.68, p 0.039). Of this population, 36 people answered the SARC-F questionnaire to assess the risk of sarcopenia and we found 38.9% of signs suggestive of sarcopenia, which indicates to continue with the investigation later and greater attention to care. The variables related to personal and health data were analyzed regarding the association with nutritional status and no statistical significance was found. Personal and health data when associated with nutritional status did not differ, however, the risk of sarcopenia was associated with the fasting glucose value (p 0.017) with low association effect. The correlation analysis using spearman rho coefficient, performed between nutritional status and nonlinear variables, found a positive relationship between obesity and glomerular filtration rate, fasting glycemia and glycated hemoglobin. Inflammatory markers will be analyzed at a later stage. CONCLUSION: The studied population represents patients with advanced stage of diabetic chronic kidney disease and the obesity rate appears high in this sample. This fact may be related to the presence of sarcpenic obesity, considering the data of the SARC-F. In addition, the positive correlations between obesity and GFR, fasting glycemia and glycated hemoglobin reflect the metabolic repercussions to which this nutritional profile is associated, according to the literature.

8
  • LUCAS CORREIA LINS
  • Analysis of fecal metabolomics in patients with inflammatory bowel disease through mass spectrometry

  • Líder : FABIANA ANDREA MOURA
  • MIEMBROS DE LA BANCA :
  • ANA LUIZA EXEL DA SILVA
  • FABIANA ANDREA MOURA
  • JORGE ARTUR PECANHA DE MIRANDA COELHO
  • JULIANA CELIA DE FARIAS SANTOS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • Data: 28-abr-2022


  • Resumen Espectáculo
  • Inflammatory Bowel Disease (IBD) is divided into Crohn's disease (CD) and Ulcerative Colitis (UC), and refers to an inflammatory pathology of chronic and idiopathic character, where there is a possible dysregulation of homeotase between the intestinal immune system and the microbiota in genetically susceptible individuals. Patients with IDI have significant differences in fecal metabolomics compared to healthy people. Metabolomics is the analysis of these metabolites that can relate to certain pathologies, including intestinal ones. The study aims to analyze the intestinal metabolic profile of patients with Inflammatory Bowel Disease followed by a specialized service in a reference hospital in Maceió/AL, using mass spectrometry. We selected 62 patients with inflammatory bowel disease who were submitted to a questionnaire for clinical evaluation, and a fecal sample was collected for analysis of metabolomics and fecal calprotectin. The control group is composed of 30 fecal samples of healthy individuals according to the inclusion criteria for the analysis of metabolites. Metabolomic data were analyzed using MetaboAnalyst 5.0 Software.

9
  • CARLOS ALEXANDRE FERREIRA DE OLIVEIRA
  • INFLAMMATORY RESPONSE AND SARCOPENIA AFTER COVID-19 INFECTION IN OBESE DIABETIC RENAL PATIENTS CHRONIC IN HEMODIALYSIS.

  • Líder : MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • MIEMBROS DE LA BANCA :
  • ALESSANDRA ABEL BORGES
  • FABIANA ANDREA MOURA
  • MERCIA LAMENHA MEDEIROS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • RAQUEL FERNANDES VANDERLEI VASCO
  • RODRIGO PEIXOTO CAMPOS
  • Data: 29-abr-2022


  • Resumen Espectáculo
  • INTRODUCTION: Diabetic nephropathy is the main cause that leads diabetic patients to hemodialysis. At this time of pandemic by COVID 19, infection caused by the new coronavirus (SARS- CoV-2), patients with diabetes, especially the obese, are part of the risk group that can evolve with the most severe presentation of the disease. In this group of patients, obese with diabetes and patients with chronic kidney disease, the inflammatory process occurs in an exacerbated manner with the uncontrolled elevation of inflammatory cytokines and may have a fatal outcome. The sarcopenia present in these diabetic, obese and oral patients also appears as a complicating factor of COVID 19, with repercussions still uncertain in the post-infection scenario. OBJECTIVE: To investigate the inflammatory response and sarcopenia after covid-19 infection in participants with chronic kidney disease and overweight/obesity, diabetics, undergoing hemodialysis. MATERIALS AND METHODS: The sample consisted of 32 diabetic patients on hemodialysis (sample calculation from the data of diabetics on dialysis according to a Brazilian survey conducted by the Brazilian Society of Nephrology - SBN, in 2017), of both sexes, assisted by the Integrated Nephrology Center of the University Hospital Professor Alberto Antunes (HUPAA), Hospital Veredas and UNIRIM. The participants were divided into two groups; A: Those with confirmed Infection by Sars-COV-2 and B: Those who did not have Sars-COV-2 infection. Demographic and laboratory data were collected. RESULTS: Group A (mean + standard deviation): n = 12 Age 60.33 + 8.03 years; BMI 31.19+1.89 Kg/m2; Dialysis time 865+689 days; Hematocrit 33.32 +4.84; Hemoglobin 10.72+1.43; Urea 148.82+31.18; Creatinine 8.53+3.04; Ca 8.35+0.49; P 5.89+1.30; Albumin 3.74+0.51; Globulins 2.96+0.52; Ferritin 229+185; PTH 460.55+350.01. Group B is described as well (mean + standard deviation): n = 30; Age 65.55 + 9 years; BMI 30.95+3.24 Kg/m2; Dialysis time 1175+768 days; Hematocrit 33.17 +4.22; Hemoglobin 11.03+1.37; Urea 139+43.91; Creatinine 7.69+2.56; Ca 8.64+0.98; P 5.1+1.82; Albumin 3.79+0.61; Globulins 3.59+1.39; Ferritin 253+197; PTH 207.76+258.31. CONCLUSION: We have not found so far a difference between the markers studied in the groups studied. More analysis is required for effective completion.

10
  • JACYARA FARIAS DE MELO
  • Association study between Childhood Trauma, Psychological Pain and Suicidal Behavior in Women with Depression

  • Líder : VALFRIDO LEAO DE MELO NETO
  • MIEMBROS DE LA BANCA :
  • ANTONIO EGIDIO NARDI
  • CLAUDIO TORRES DE MIRANDA
  • JORGE ARTUR PECANHA DE MIRANDA COELHO
  • JULIANA CELIA DE FARIAS SANTOS
  • VALFRIDO LEAO DE MELO NETO
  • VERONICA DE MEDEIROS ALVES
  • Data: 29-abr-2022


  • Resumen Espectáculo
  • This study aims to investigate in depressed women the association between a history of childhood trauma with psychological pain and suicidal behavior. This is an observational, cross-sectional study with a quantitative approach that was carried out at Hospital Escola Portugal Ramalho (HEPR), University Hospital Profº Alberto Antunes (HUPAA) and at Basic Health Units (UBS) in Girau do Ponciano. The display method used was non-probabilistic for convenience and the sample consisted of patients in outpatient care. Data collection took place from the application of the Sociodemographic Questionnaire, Mini International Neuropsychiatric Interview (MINI 7.0.2), Beck's Depression Inventory (BDI), Psychological Pain Scale (PAS) and Childhood Trauma Questionnaire (CTQ) . The general sample included 34 women, with a mean age of 42.1 years (± 11.0). About 82.3% (28) of the sample had a history of early trauma, 79.4% (27) of the women reported having suffered Emotional Abuse, 73.5% (25) reported having suffered Physical Negligence, 70.6% ( 24) reported having suffered Emotional Negligence, 58.8% (20) reported having suffered Physical Abuse and 47% (16) of the women interviewed reported having suffered Sexual Abuse. The average Suicidality score was 69.2 (± 47.8) (p 0.03) for patients who had a history of Emotional Abuse, 59.3% (16) of these patients had a Major Depressive Disorder (p 0 , 04) and 40.7% (11) presented with Bipolar Disorder (p 0.04). 96% (24) of the patients who reported Physical Negligence had Passive Ideation (p 0.02) with OR = 12.0 (95% CI 1.05 - 136.79) and 80% (20) had Active Ideation (p 0, 01) with OR = 8.0 (95% CI 1.46 - 43.68). For women who suffered Emotional Negligence the average Suicidality score was 72.9 (± 47.3) (p 0.01), the average BDI score was 31.5 (± 14.2) (p 0 , 02). 29.5% (7) of the patients presented with Bipolar Disorder Type 1 (p 0.05). Among the patients who reported a history of Physical Abuse, 50% (10) of them had Major Depressive Disorder (p 0.01) and 50% (10) had Bipolar Disorder (p 0.01) with OR = 13.0 (95% CI 1.42 - 119.07). The statistical tests used in this study showed an association between mood disorders and suicidal behavior according to the subtypes of abuse in childhood and adolescence. It was also observed that even in psychiatric follow-up, patients who have a history of early trauma have high scores for the severity of depressive symptoms and for the risk of suicide

11
  • THAYS DE SA TARGINO LIBERAL
  • The itinerary traveled by caregivers of children and adolescents with mental disorders in the search for specialized treatment in the state of Alagoas

  • Líder : CLAUDIO TORRES DE MIRANDA
  • MIEMBROS DE LA BANCA :
  • CLAUDIO TORRES DE MIRANDA
  • MERCIA LAMENHA MEDEIROS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • ALESSANDRA PLACIDO LIMA LEITE
  • ANTONIO CARLOS SILVA COSTA
  • DANIELA MARTINS LESSA BARRETO
  • Data: 03-may-2022


  • Resumen Espectáculo
  • INTRODUCTION: According to estimates, about 13% of children and adolescents in Brazil have some psychopathy and that only 37.5% of them receive some therapeutic intervention over 5 years. The gap between prevalence and access to specialized treatment demonstrates that some factors may interfere with the coverage and efficacy of mental health care for this population. The main barriers of access faced by family members involve both personal factors (financial situation, abdication of social commitments and physical and emotional exhaustion required in care) and factors related to deficiencies in the care network, such as: disarticulation in services, lack of investments, specialized professionals and procrastination in diagnosis. The sequence of the itinerary tends to be adjusted according to the particularities of the users and is usually preceded by care in the Basic Health Units (UBS), Emergency Care Units (UPA) and psychiatric hospitals, involving a diversity of professionals until the arrival at the Psychosocial Care Center for Children and Adolescents. Regarding the specialized network, Alagoas has only one CAPSi unit, a reference in the care of children and adolescents aged 5 to 18 years, with some serious mental disorder. OBJECTIVE: To analyze the path taken by family members or caregivers for mental health treatment of children and adolescents treated in a MACEIÓ CAPSi; identify the motivations for seeking treatment, trying to understand the difficulties and strategies used in this process and describe the factors related to treatment abandonment. MATERIALS AND METHODS: This is an exploratory, descriptive and qualitative study, based on the theoretical and methodological precepts of therapeutic itineraries. The sample consisted of 29 participants, divided with the following organization: 20 responsible for children or adolescents with mental disorders in care at CAPSi and 9 guardians who abandoned treatment between 2019 and 2020. The sampling was performed for convenience, taking into account the scheduling of consultations for psychiatrists performed at CAPSi, during the months of May and June 2021. In the case of dropouts, a search was carried out in the archive of inactive medical records, from which the first 9 that fit the described period were selected, and in which it was possible to contact through the telephone number informed. Data collection was performed through semi-structured interviews, composed of open questions elaborated by the researchers. The data produced by the interviews were worked in the qualitative typology, with the help of atlas ti software version 9, following the theoretical-methodological approach of thematic content analysis proposed by Minayo, in its three phases of analysis: Pre-Analysis, Exploration of the material and Treatment of the results obtained and interpretation. RESULTS: Considering the demographic profile of the participants, 75% showed the maternal figure, in the age group of 41 to 50 years, as the main responsible for the child or adolescent in the treatment in capsi. The predominance of family income of a minimum wage, low schooling and non-exercise of paid activity comprised the characteristic factors of a population in social vulnerability. Among users, higher frequency was observed in males, aged between 11 and 13 years, with length of stay in CAPSi up to two years. The predominant diagnostic groups were F70-79 (Mental retardation), F 84 (Global Child Development Disorders) and F 91 (Conduct Disorders). The results of the interviews were organized into three themes: Motivation to seek help; Paths traveled / difficulties until arrival at CAPSI and Reasons for withdrawal from treatment. Among the interviewees, what motivated the search for help were changes in the child's behavior, such as hyperactivity, heteroaggressiveness and introspection, perceived mainly by the mother, between 2 and 4 years. The therapeutic itinerary was described as a long and exhausting stage, in which family members moved between several establishments in the primary care of the SUS, complementary units of mental health services, as well as professionals from the private network. The average number of professionals accessed was 6 and the average time spent until referral and arrival at CAPSi was 4 years. Lack and/or long wait for vacancy, dissatisfaction with therapies, refusal to accept the diagnosis, stigma and maternal burden were the most cited difficulties in the pilgrimage for specialized treatment. The CAPSi in general was well evaluated by users, mainly by trained professionals, family reception and availability of medications, but insatisfações were recorded in the says res

12
  • LARISSA DA SILVA PINTO
  • Impact of anxiety and depression on quality of life in chronic rheumatologic diseases in childhood

  • Líder : THIAGO SOTERO FRAGOSO
  • MIEMBROS DE LA BANCA :
  • ALINE CAVALCANTI DE QUEIROZ
  • AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
  • FLAVIO TELES DE FARIAS FILHO
  • ROBERTO CORDEIRO DE ANDRADE
  • RODRIGO PEIXOTO CAMPOS
  • THIAGO SOTERO FRAGOSO
  • Data: 21-jun-2022


  • Resumen Espectáculo
  • INTRODUCTION: Pediatric systemic lupus erythesis (pLES) and juvenile idiopathic arthritis (JISA) are chronic rheumatologic diseases that affect the infant age group. In addition to organic systemic impairment, these conditions are associated with the occurrence of depression and anxiety, causing a negative impact on quality of life. OBJECTIVE: To trace the sodium demographic profile; Estimate anxiety and depression rates in patients with pediatric systemic lupus erytheams (pLES) and juvenile idiopathic arthritis (JIS); Measure the level of quality of life; Correlate anxiety and depression to the level of quality of life; Associate anxiety and depression with disease activity; To compare quality of life in groups with and without disease activity. MATERIALS AND METHODS: Observational study and cross-sectional study. The sample was selected by convenience, composed of patients with pLES and AIJ followed by the Pediatric Rheumatology outpatient clinic of the Professor Alberto Antunes Hospital, a tertiary hospital in a capital of the Northeast. We included patients of both sexes aged between 7 and 17 years whose parents signed the Informed Consent Form (Informed Consent). Data were obtained through a face-to-face interview. The variables of analysis were: socioeconomic data; anxiety (via the Screen for child anxiety related disorder- SCARED) questionnaire, depression (from the Children's Depression Inventory - CDI) instrument, quality of life level (using the Pediatric Quality of Life InventoryTM Scale Version 4.0- PedsQualis ), activity of p Les (through the modified systemic lupus erythematosus disease activity index- 2k - SLEDAI) and activity to AIJ (from the Clinical Juvenile arthritis disease activity score- cJADAS score). The analyses were made with the help of the statistical package JAMOVI version 1.6.3.0. Descriptive data are represented by means, median, frequencies, standard deviation and interquartile interval. The Shapiro-Wilk test was used to verify the normality of the distribution of the variables. The comparison between two means was made by the t-Student test. P< 0.05 values were considered statistically significant. Spearman's test was used to correlated nonparametric variables. For the association of two categorical variables, fisher's chi-square and exact tests were selected. RESULTS: There were 26 participants with a mean age of 11.2 ± 2.94 years, the majority of which were female (80.8%), coming from the interior of the state (69.2%) and belonging to economic class 6 (73.1%). Anxiety and depression rates were 50% and 11.5% respectively. The average quality of life was 70.6 + 18.1. There was a negative correlation of anxiety to the domains of emotional quality of life (rho= -0.707, p < 0.001) and school (rho= - 0.532, p < 0.005). Depression showed a negative correlation to the physical (rho= -0.632; p< 0.001), emotional (-0.564; p < 0.003) and school (-0.613; p< 0.001) domains of quality of life. Disease activity was not associated with anxiety, x 2 (1)= 1.39 (p=0.238) or depression x 2 (1)= 0.399 ( p=0.580). In this study, those with disease activity (M = 69.5; SD = 18.6), obtained similar means of quality of life in relation to those without disease activity (M = 71.7, SD = 18.2) with no significant difference (p=0.763). CONCLUSION: The impairment in the emotional, school and physical domains of quality of life in patients with rheumatologic diseases in childhood is correlated with depression and anxiety. There is no association between disease activity and quality of life and mental disorders evaluated in this study.

13
  • CARLA SANTOS DE LIMA
  • Bacteremia and mortality among patients with short-term and tunneled catheters for hemodialysis

  • Líder : RODRIGO PEIXOTO CAMPOS
  • MIEMBROS DE LA BANCA :
  • ALINE CAVALCANTI DE QUEIROZ
  • ALYSSON WAGNER FERNANDES DUARTE
  • DANIELLA BEZERRA DUARTE
  • FLAVIO TELES DE FARIAS FILHO
  • MARIA ELIETE PINHEIRO
  • RODRIGO PEIXOTO CAMPOS
  • Data: 25-ago-2022


  • Resumen Espectáculo
  • Introduction: Central venous catheters (CVCs) for hemodialysis (HD) can be short-term catheters (STC) or tunneled catheters (TC). Bacteremia and dysfunction are complications that can impact morbidity and mortality. We decided tocompare the rates of bacteremia and dysfunction between STC and TC and the survival of patient survival 90 days after catheter insertion. Methods: Retrospective cohort to evaluate CVCs inserted between January 2011 and December 2020 in a tertiary hospital. CVCs in patients with end-stage chronic kidney disease were included. Patients with acute kidney injury, CVC that lasted less than three HD sessions, and patients who died within one week after insertion were excluded. Bacteremia and dysfunction rates, bacteremia-free survival, and dysfunction-free survival were investigated. Multivariate analysis was performed using a Cox proportional hazards regression model for patient survival at 90 days. Results: A total of 670 catheters were analyzed in 287 patients, which were 422 STC (63%) and 248 TC (37%). The rates of confirmed bacteremia per 1,000 catheter-days were 1.19 for STC and 0.20 for TC (p < 0.0001). The rates of confirmed or suspected bacteremia were 2.27 and 0.37 per 1,000 catheter-days for STC and TC, respectively (p < 0.0001). The dysfunction rates were 3.96 and 0.86 for STC and TC, respectively (p < 0.0001). Patient survival at 90 days was higher in the TC group compared to the STC group (96.8% vs 89.1%; p < 0.0001). Age in years (HR 1.033: 95% CI 1.009-1.057), albumin in g/dl (HR 0.278: 95% CI 0.154-0.505) and use of STC (HR 2.807: 95% CI 1.048-7.521) were the variables that influenced mortality 90 days after insertion. Conclusion: We found lower rates of bacteremia and dysfunction for TC, in addition to demonstrating that the use of STC influences patient mortality.

14
  • MELINA PIMENTEL CAVALCANTE PEDROSA
  • Study of association between early trauma and clinical manifestations in patients with fibromyalgia.

  • Líder : VALFRIDO LEAO DE MELO NETO
  • MIEMBROS DE LA BANCA :
  • ANDRÈ BARCIELA VERAS
  • CLAUDIO TORRES DE MIRANDA
  • MARIA CICERA DOS SANTOS DE ALBUQUERQUE
  • MERCIA LAMENHA MEDEIROS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • VALFRIDO LEAO DE MELO NETO
  • Data: 29-ago-2022


  • Resumen Espectáculo
  • Introduction: Fibromyalgia (FM) is a chronic painful syndrome that affects mostly adult women (18-55 years). It has a prevalence of approximately 2.5% in the Brazilian population. Estimated at 2% to 8% in the world population. It is characterized by generalized musculoskeletal pain, often accompanied by fatigue, non-restorative sleep, cognitive disorders, anxiety, and depression. There is no well-established etiology and causes as well as an enlightened pathophysiology. Current studies have demonstrated the association between early trauma as a factor of worsening in the quality of life of fibromalgic patients as well as a triggering factor for changes in pain modulation and greater psychic distress. Objective: The general objective of this study is to investigate the association between the history of early trauma and the clinical characteristics in women with FM. Methodology: This is an observational, cross-sectional and quantitative study conducted at the pain medicine service of the general outpatient clinic of the Professor Alberto Antunes University Hospital (HUPAA) of the Federal University of Alagoas (UFAL). The sample is non-probabilistic and convenience performed during the period of outpatient care. 50 women with FM participated in the research. Data collection occurred based on a sociodemographic and clinical questionnaire, diagnostic questionnaire and validated psychometric questionnaires. The diagnostic criteria for FM of the American Society of Rheumatology (ACR) were applied to confirm the diagnosis; the questionnaire on the impact of FM (IQ) that assesses functionality and quality of life; The analogous visual scale (VAS), to assess intensity of physical pain; Psychache Scale to assess the intensity of psychological distress; Beck Depression Inventory (BDI), to measure the intensity of depressive symptoms and the Early Trauma Self-Assessment Inventory: Reduced Version (ETISR-SF) that assesses the history of trauma up to 18 years of age. Results: 41 of the 50 women reported some type of history of early trauma, with a prevalence of 82% in the sample. 62% reported general trauma, 72% reported physical abuse, 66% reported emotional abuse and 50% reported sexual abuse. The mean age of the participants was 49.84 (±8.25), 58% had a partner and the mean schooling was 7(±5.77) years of schooling. There were no significant differences regarding the sociodemographic characteristics of the group with or without a history of trauma. Dysfunction, depressive symptoms, psychological pain and diagnostic criteria scores (CRF) were more intense in fibromyalgic patients with a history of early trauma (P< 0.025; P<0,000; p<0,000; p <0,003, respectively) compared to the group without a history of trauma. Women who suffered sexual abuse were more severe in all related aspects, including the intensity of physical pain(p<0,016). Conclusion: Patients with FM who had a history of early trauma present greater severity of depressive symptoms, dysfunction, psychological pain and higher score in the diagnostic criteria of CRF than the group without a history of early trauma. Sexual abuse is the type of trauma that negatively impacts with more intensity on all criteria evaluated, in addition to physical pain, a characteristic that was not statistically significant in other types of early trauma.

15
  • BRUNA KELLEN WANDERLEY PORTO
  • Risk factors associated with loss of productivity at work

    in patients with Systemic Lupus Erytheamus

  • Líder : THIAGO SOTERO FRAGOSO
  • MIEMBROS DE LA BANCA :
  • ANTONIO LUIZ RIBEIRO BOECHAT
  • AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
  • CLAUDIO TORRES DE MIRANDA
  • SAMIR BUAINAIN KASSAR
  • THIAGO SOTERO FRAGOSO
  • VALFRIDO LEAO DE MELO NETO
  • Data: 22-sep-2022


  • Resumen Espectáculo
  • INTRODUCTION: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune
    disease involving multiple organs. Prevalence of work disability (WD) respectively
    within 5 years after diagnosis ranges from 15% to 40%, increasing to 36% and 51% at
    10 and 15 years. Several risk factors for work dysfunction have been reported in several
    SLE patients, including sociodemographic, environmental and disease-related issues.
    Although several studies have public consequences for productivity in SLE, none has
    evaluated the Brazilian targets. OBJECTIVES: To determine the prevalence and risk
    factors associated with WD in patients with SLE. METHOD: cross-sectional study
    carried out at the SLE Outpatient Clinic of the Rheumatology Service of the University
    Hospital of Alagoas, Brazil. The sampling was non-probabilistic for convenience,
    consisting of 110 patients in outpatient care. Data collection was based on the
    application of the Sociodemographic and Occupational Questionnaire, ABEP&#39;s Brazilian
    Economic Classification Criteria, MAT (Measurement of Adherence to Treatment), SF-
    12 (The 12-item Short Form Survey), SLICC (The Systemic Lupus International
    Collaborating Clinics/ American College of Rheumatology – Damage Index), SLEDAI
    (The Systemic Lupus Erythematosus Disease Activity Index), in its 2K modified
    version, and analysis of medical records. As for the statistical analysis, the Shapiro-
    Wilk test evaluated the normality of the distribution of continuous variables, which
    were compared using the Mann-Whitney test. Chi-square, Chi-square with continuity
    correction or Fisher&#39;s exact tests were performed to compare categorical variables. The
    association between sociodemographic, occupational and clinical factors with work
    disability was assessed using logistic regression. RESULTS: The sample consisted of
    98.1% female participants, with a median age of 38.5 (IQR 18) years, 78.1% non-
    Caucasians, with more than 10 years of schooling in 62.7% of participants, with 74.5%
    of the sample framed in social vulnerability status, with an average income of up to
    R$1,100.00, equivalent to US$212.76. As for occupational profile, 83.6% were inactive
    at the time of the research, while 64.55% had an active current income and 47.2%
    received social security benefit due to a temporary or permanent poor health condition.
    75.4% came to work in jobs that required high physical demand life habits. As for life
    habits, 3.6% of the participants said they were alcoholics, 1.8% said they were smokers,
    24.5% said they practiced regular physical exercise. The prevalence of WD due to SLE
    in our sample was 76.3%. In the univariate analysis, the significant predictors of labor
    dysfunction were older age, less than 10 years of education, married marital status,
    occupational position with high physical demand and not practing physical exercise. In
    the multivariate analysis, an association was found between WD and less than 10 years
    of education (p=0.028). Clinical characteristics were not significant predictors of work-
    related dysfunction. Participants with less than 10 years of education were 5.33 times
    more likely to have work disability. CONCLUSION: More than half of the sample
    (76.3% of the participants) presented loss of productivity at work. Less than 10 years of
    education was a predictor of work disability in this population.

16
  • MARIANA NOVAES SANTOS
  • Familial Adenomatous Polyposis in Alagoas

  • Líder : ISABELLA LOPES MONLLEO
  • MIEMBROS DE LA BANCA :
  • LAVÍNIA SCHULER FACCINI
  • BENEDITO MAURO ROSSI
  • ISABELLA LOPES MONLLEO
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • Data: 12-dic-2022


  • Resumen Espectáculo
  • Background: Familial adenomatous polyposis (FAP) is a hereditary colorectal cancer syndrome caused by germline variants of APC gene, with autosomal dominant inheritance and nearly complete penetrance of colorectal cancer if left untreated. The global care of patients with FAP includes timely prevention, diagnosis and surgical intervention strategies. Thus, the reduction of systemic barriers in the access of patients to information and healthcare is critical to disease management. This research was the first step for the knowledge of the molecular epidemiology of hereditary colorectal cancer syndromes in Alagoas and it focuses on the study of a family with multiple individuals affected by intermediate FAP. It aims to describe socioeconomic, health literacy, clinical and genetic characteristics of this family. Methods: his cross-sectional and observational study enrolled 54 participants. Data was collected through an inhouse clinical and socioeconomic questionnaire, the Brazilian-validated Health Literacy Test (from Portuguese, TLS), which scores from 0 to 100. Additionally, the medical records of the family members followed at the University Hospital of Federal University of Alagoas were reviewed and pedigree draft and biologic samples for family’s variant identification were obtained. Socioeconomic data will be used for the Family Development Index (from Portuguese, IDF) calculation, which scores from 0 to 1. IDF and TLS scores and clinical data were recorded on Excel and were descriptively analyzed using the statistical program JASP. Genes of interest were screened by next-generation sequencing in the index case. Results were confirmed through Sanger sequencing in the index case and allele-specific polymerase chain reaction (PCR) in four affected participants and three negative controls (intra and extrafamilial). In silico pathogenicity prediction analysis of the identified variant was performed. Results: Three hundred and twenty-seven individuals, with 32 living affected relatives, were mapped through the pedigree analysis. analysis. Most of them lived 5 km away from the healthcare unit in poor houses, with no piped water and electricity until a few years ago. The mean IDF was 0.476 and the TLS score was 23.4. Among the 54 interviewed, fourteen were diagnosed with FAP and had, in general, late diagnosis and inadequate management and surveillance. The APC heterozygous germline variant c.1255del (p.Thr419Profs*35), which has never been previously reported, was identified in the affected participants. In silico analysis confirmed the pathogenicity of the genetic alteration, since it leads to early truncation and loss of all functional domains of APC protein. Conclusions: Difficult access to healthcare services, low health literacy and economic conditions were the major patient-level barriers to global care  identified. The analysis of the genetic data enabled the identification of the genetic causing variant of FAP in this family, the confirmation of its autosomal dominant segregation and the development of a specific molecular diagnostic test, which is available for all interested relatives, after pre-test genetics counseling. Serving as translational research, a partnership with the Municipal Health Department was established and the study results might be used to overcome barriers aiming to improve individual and collective global care.


17
  • JULIANA DOS SANTOS OLIVEIRA
  • Pediatric acute leukemias: Identifying genes that relate to the
    therapeutic prognosis

  • Líder : CAROLINNE DE SALES MARQUES
  • MIEMBROS DE LA BANCA :
  • ALINE CAVALCANTI DE QUEIROZ
  • AMANDA KARINE BARROS FERREIRA RODRIGUES
  • BRUNA DEL VECHIO KOIKE
  • CAROLINNE DE SALES MARQUES
  • JUSSARA ALMEIDA DE OLIVEIRA BAGGIO
  • Data: 14-dic-2022


  • Resumen Espectáculo
  • Acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), neoplasms of the hematopoietic system, are hematological malignancies that affect adults and children, with great involvement in the latter. Analyzing these mutations allows for greater knowledge about drug resistance, complications arising from treatment, relapses and chances of cure - resulting in a better prognosis. Thus, the objective of this study was to analyze the gene expression, which is related to the therapeutic prognosis, in patients with acute myeloid and lymphoid leukemia. This is an observational, cross-sectional analytical study carried out in the pediatric oncology ward of Hospital Veredas with children, aged between 0 and 19 years old, diagnosed with leukemia. Previously, a patent was built aiming at the identification of genes related to prognosis, with regard to survival and recurrence of acute myeloid leukemias. Analysis for lymphoid subtype is ongoing. Subsequently, the evaluation of the biological material will allow the identification of the profile of the research participants. The S1PR4, PBX4, FAM171A1, RARRES2, HPGD, CD1C and PAM genes were identified in the pediatric patient group for both disease severity and negative association with AML survival. The FAM171A1, RARRES2 and PAM genes were identified in the analysis for chemoresistance. The sample, so far, consists of 13 patients, with a mean age of 7.83 years old (standard deviation of ± 7.7 years old), with 7 children (53.84%) being male. The mean time between the first symptoms and diagnosis was 55 days - the shortest and longest time, respectively: 7 and 180 days. The initial signs and symptoms, with the highest recurrence, that led to the search for a diagnosis were: pain in the lower limbs (30.76%) and pallor (23.07%). As for the type of leukemia, 10 (76.92%) patients were diagnosed with ALL, with type B being more prevalent (69.23%). No child had CNS infiltration, according to chart analysis. Spinal cord relapse was confirmed in 3 (23.07%) patients, who were on new anticancer treatment, with 2 (66.66%) of them waiting on the list for BMT. It is concluded that the knowledge of gene expression, in the sample obtained, will make it possible to present prognoses, resulting in possible improvements in the making of therapeutic decisions, regarding the treatment of pediatric leukemias.

18
  • PATRICIA PEREIRA NUNES RIBEIRO
  • Chronotype evaluation in patients with chronic kidney disease on hemodialysis

  • Líder : FLAVIO TELES DE FARIAS FILHO
  • MIEMBROS DE LA BANCA :
  • MARIO ANDRE LEOCADIO MIGUEL
  • CLAUDIO TORRES DE MIRANDA
  • DANIELLA BEZERRA DUARTE
  • FLAVIO TELES DE FARIAS FILHO
  • MARIA DO CARMO BORGES TEIXEIRA
  • VALFRIDO LEAO DE MELO NETO
  • Data: 15-dic-2022


  • Resumen Espectáculo
  • INTRODUCTION: The prevalence of sleep disorders is higher in patients with
    kidney disease (CKD) than in the general population. These patients when on hemodialysis
    are distributed in treatment shifts that constitute an appointment that occurs
    three times a week, and that can interfere with the sleep-wake cycle. Changes in rhythms
    have been observed in patients with CKD and there is accumulated evidence of
    that some of them can negatively affect health. Cronodiseruption refers to the
    chronic interruption of circadian rhythms leading to the disease. Changes in the cycle
    sleep-wakein in hemodialysis patients impact on quality of life and may
    endogenous circadian rhythms. Social jet lag is a term that describes the
    misalignment between social and biological times conventionally opposing days of
    work free days. OBJECTIVE: To investigate whether there is social Jet Lag related to
    hemodialysis, assess the chronotype of chronic renal patients on haemodialysis and whether there is
    inconsistency between the chronotype and the dialysis shift. METHODS: A total of 194
    hemodialysis patients from three local dialysis units were enrolled in February
    june 2022. The chronotype was estimated using morning-eveningness
    Questionnaire (MEQ) and a modified version of the Munich Chronotype Questionnaire
    (MCQT) was used to estimate the social Jet Lag related to hemodialysis.
    RESULTS: Hemodialysis-related jet lag was 48.1 ± 1.4 min (range 0 -
    4:57) and was inversely correlated with age (r=-0.216, p=0.01). The chronotype was
    distributed in 2.1% moderately related, 31.4% intermediate, 39.2%
    moderately morning and 27.3% definitely in the morning. Forty-four
    patients (22.7%) were being treated in the morning shift, 96 (49.5%) in the
    afternoon and 54 (27.8%) in the night shift. The inconsistency between the treatment shift and the
    chronotype was detected in 38 (19.6%) and was related to higher scores of the
    MEQ (p&lt;0.001). CONCLUSION: Therefore, this study seems to indicate that there may be
    hemodialysis-related social jet lag, that morning chronotype is the most frequent
    in hemodialysis patients and the highest MEQ score is related to
    inconsistency between the shift and the chronotype.

2021
Disertaciones
1
  • THAYSA KELLY BARBOSA VIEIRA TOME
  • Circadian rhythm reprogramming, type 2 diabetes and cancer progression: a meta-analysis of transcriptome data

  • Líder : CARLOS ALBERTO DE CARVALHO FRAGA
  • MIEMBROS DE LA BANCA :
  • ALINE CAVALCANTI DE QUEIROZ
  • AMANDA KARINE BARROS FERREIRA RODRIGUES
  • ANDRÉ LUIZ SENA GUIMARÃES
  • CARLOS ALBERTO DE CARVALHO FRAGA
  • FABIANA ANDREA MOURA
  • JULIANA CELIA DE FARIAS SANTOS
  • Data: 14-may-2021


  • Resumen Espectáculo
  • Introduction: Tumorigenesis is affected by clock genes. Changes in the expression of clock genes can increase cancer susceptibility through the effects on biological mechanisms that regulate DNA damage and repair, energy metabolism, cell growth and death in neoplastic tissues (NIRVANI et al, 2018; GERY, 2010). Objective: to analyze the association of circadian rhythm, type 2 diabetes and cancer. Methodology: The study is a meta-analysis performed on type 2 diabetes, genes related to circadian rhythm and transcriptome data associated with breast, bladder, liver, pancreas, colon and rectum cancer using the integration of gene expression profiles with biomolecular in genome scale networks in diabetes samples, the databases searched were Pubmed and TCGA. The descriptors circadian rhythm, type 2 diabetes and cancer in English were used with Boolean operators and or orResults: several common genes deregulate in diabetes mellitus and cancer. KLF10, NTKR3, IGF1, USP2, EZH2 were both down-regulated in samples of type 2 diabetes and cancer, while ARNTL2 AND AGRP were up-regulated. It appears that changes in mRNA are contributing to phenotypic changes in type 2 diabetes, resulting in phenotypic changes associated with malignant transformation. Taking these genes to perform a survival analysis, we found only the IGF1, USP2 and ARNTL2 genes associated with patient results. While negative regulation of IGF1 and USP2 had a negative impact, positive regulation of ARNTL2 was associated with poor survival in BLCA and BRCA cancer samples. Conclusion: our data stimulate efforts in new studies to achieve experimental and clinical validation on these biomolecule

2
  • MARIA LUISA MELO BARBOSA
  • Effects of physical training with exergames in sedentary and/or overweight adolescents.

  • Líder : MERCIA LAMENHA MEDEIROS
  • MIEMBROS DE LA BANCA :
  • CLAUDIO TORRES DE MIRANDA
  • FLAVIO TELES DE FARIAS FILHO
  • LUIZ RODRIGO AUGUSTEMAK DE LIMA
  • MERCIA LAMENHA MEDEIROS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • SAMIR BUAINAIN KASSAR
  • Data: 28-jun-2021


  • Resumen Espectáculo
  • Obesity is defined as a chronic disease, endemic with multifactorial origin, which has increased considerably in recent decades. Metabolic alterations that result in obesity and overweight, acquired in childhood, can accompany the individual throughout life, and sedentary lifestyle is one of the responsible for this evolution. Physical training with exergames can be an alternative to increase the level of physical activity and combat obesity. Objective: To evaluate the effects of physical training intervention with Exergames in sedentary and/or overweight adolescents. Methodology: Uncontrolled clinical trial with non-probabilistic sample. The individuals analyzed were adolescents (n=20), between 10 and 17 years of age, all genders. Variables such as body mass index, fat percentage, glycemia, total cholesterol, HDL, LDL, triglycerides, muscle endurance and flexibility Pre and Post intervention of 24 sessions with exergames were collected. Results: Physical training with exergames, for 2 months, produced a decrease in body fat percentage, risk factors and hdl elevation, associated with cardiovascular diseases, even though there was no significant change in body mass index. Conclusion: There was a reduction in the percentage of fat, systolic blood pressure and heart rate in adolescents undergoing physical training with exergames, and there was a tendency to reduce risk factors for cardiovascular diseases.

3
  • RAFAELA MONTEIRO DO NASCIMENTO FOLHA
  • Factors associated with perinatal mortality in
    a high-risk school maternity in the Northeast
    of Brazil

  • Líder : SAMIR BUAINAIN KASSAR
  • MIEMBROS DE LA BANCA :
  • RICARDO QUEROZ GURGEL
  • AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
  • CLAUDIO TORRES DE MIRANDA
  • JOSE ELIAS SOARES DA ROCHA
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • SAMIR BUAINAIN KASSAR
  • Data: 03-ago-2021


  • Resumen Espectáculo
  • home and that for the reduction of deaths

    early fetal and neonatal diseases, the indicators of perinatal mortality are stable,

    despite the significant reduction in infant mortality observed
    since the early 2000s. The occurrence of fetal deaths and
    early neonatal deaths are closely related to the
    quality of prenatal, intrapartum and postpartum care offered
    pregnant women, so that the investigation of the factors associated with
    these deaths will underpin public policy adaptations
    able to reduce the occurrence of perinatal outcomes
    Unwanted. we intend to identify sociodemographic factors,
    maternal and care-related mothers associated with perinatal mortality in

    a population of pregnant women, puerperated women and neonates admitted to
    a maternity school in northeastern Brazil, between June
    2015 to May 2016 and generate data that collaborates with the
    planning of maternal and child care. a study was carried out
    prospective cohort approach. The subjects were pregnant
    admitted to the Santa Monica Maternity School, located in the
    municipality of Maceió, State of Alagoas (Northeastern Brazil),
    between June 2015 and May 2016. Having as factors of
    exposure to sociodemographic, obstetric,
    care delays and maternal near miss, the data were
    collected through interviews and medical records. Measures of
    frequency were generated through the Epi Info 3.5.1.A
    bivariate analysis was performed at Open Epi to calculate the
    risk association considering the significance level of
    5%. Subsequently, the variables with p&lt;0.02 were included in the
    multivariate analysis, through multiple logistic regression
    stepwise, from a Hierarchical Theoretical Model having as
    variable dependent on perinatal mortality. They joined
    perinatal mortality to be held in perinatal mortality.
    prenatal care in a number of less than six, the non-
    the presence of congenital malformations, the presence of
    management criteria for maternal near miss and the first delay
    Care. In our study, we can infer that the factors
    determinants of perinatal mortality were associated with the quality of
    in maternal health care offered, from the care

    to the intra-hospital level required a restructuring of the
    and qualification of maternal and child care in a system that is more
    regionalized and paid-up.

4
  • CHRYSTENISE VALÉRIA FERREIRA PAES
  • Prenatal care through the Unified Health System in cases of oral clefts

  • Líder : ISABELLA LOPES MONLLEO
  • MIEMBROS DE LA BANCA :
  • ISABELLA LOPES MONLLEO
  • IVANISE GOMES DE SOUZA BITTENCOURT
  • JOVANIA MARQUES DE OLIVEIRA E SILVA
  • MERCIA LAMENHA MEDEIROS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • SAMIR BUAINAIN KASSAR
  • Data: 13-ago-2021


  • Resumen Espectáculo
  • Oral clefts are defects with high prevalence in low- and middle-income countries (1:730 newborns) and significant morpho-functional impairment. Prenatal diagnosis allows health interventions to minimize complications associated with low weight gain and increased neonatal morbidity and mortality. Aiming to assess prenatal care in cases of oral clefts, this was a prospective, cross-sectional, and descriptive study. The sample comprised 86 mother-child dyads with oral clefts registered in the Brazilian Database on Craniofacial Anomalies (BDCA) by Brazil’s Craniofacial Project participating services, between January/2019 and April/2020. Sociodemographic, clinical, and genetic data were extracted from the BDCA, while face-to-face or phone interviews to obtain prenatal information. Results showed failures in identifying oral cleft-related risk indicators during prenatal. Almost a third of mothers had a prenatal diagnosis. However, it did not produce changes in the way prenatal teams manage their healthcare. Globally, results showed that primary health teams are not skilled in dealing with oral cleft diagnosis, sheltering pregnant women, and managing the situation. These failures have delayed the referring and binding of the dyads to an oral cleft specialized service which impacts treatment and prognosis. Through this study, it was possible to identify needs and opportunities for increasing oral cleft health care. The authors present a proposal for permanent education and reference and counter-reference in oral clefts during pre and neonatal life periods.

5
  • CAMILA MODESTO NACIFE ADAME
  • ESTIMATION OF GLOMERULAR FILTRATION RATE IN OBESE PATIENTS: comparative evaluation between formulas for calculation

  • Líder : FLAVIO TELES DE FARIAS FILHO
  • MIEMBROS DE LA BANCA :
  • CARLOS ALBERTO DE CARVALHO FRAGA
  • FLAVIO TELES DE FARIAS FILHO
  • LIVIA LEITE GOES GITAI
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • THIAGO SOTERO FRAGOSO
  • VALFRIDO LEAO DE MELO NETO
  • Data: 26-ago-2021


  • Resumen Espectáculo
  • Obesity is one of the most prevalent metabolic disorders of the 21st century. Its growing epidemic generates important consequences in public and individual health such as: diabetes, cardiovascular complications, cancer, asthma, sleep disorders, liver dysfunction, renal dysfunction and infertility (MANNA and JAIN, 2015).

    Its etiology is complex and multifactorial, resulting from the interaction of genetic, environmental, emotional and lifestyle factors. Decreased physical activity and increased consumption of high caloric density foods are determining factors (abeso guideline, 2016). In humans, several other reward and emotional factors play a role in food intake, in addition to hunger (guideline of the endo Society 2014).

    The disease not associated with genetic syndromes has polygenic inheritance, and the environment plays a fundamental role in genetically susceptible individuals (abeso guideline, 2016). Lifelong dietary patterns play a strong role in the development of chronic diseases, including diabetes and hypertension, the main risk factors for end-stage kidney disease (STD) (CAMARA et. al, 2017)

    By 2025, an estimated 2.3 billion adults around the world are overweight, of which 700 million are diagnosed with obesity (WHO website). In Brazil, there was an increase of 67.8% in the years 2006 to 2018, representing a prevalence of 19.8% in the latter. Currently in the country, 20.7% of women and 18.7% of men are obese (ABESO website).

    To define it, the WHO uses body mass index (BMI), body weight measurement adjusted for height, weight (kg)/height(m2). Calculation of simple interpretation and better correlation with other estimates of adiposity, besides eliminating the need for height/weight tables for specific genera. It is based on the observation that body weight is proportional to square dwell in adults with preserved anatomical composition (BRAY et al., 2018)

    Studies with human and animal models show an association between obesity and end-stage renal disease, even after adjustments for systemic arterial hypertension and diabetes mellitus (MUNUSAMY et al., 2015). Around 50% of patients with type 2 diabetes mellitus will develop CKD, with obesity accounting for a 23% increase in risk. In addition, it is a risk factor for nephrolithiasis and renal neoplasia, influencing prognosis and associating with worse outcomes (TAHERGORABI, Z. et al., 2016).

    The kidney and adipose tissue of the obese individual secrete pro-inflammatory cytokines, such as angiotensin II and leptin, among other adipocytokines with effects on doucytes, mesangial and tubular cells, which also express insulin and leptin receptors, crucial for maintaining cellular permoseletivity. The larger the adipose tissue, the greater the circulation of these substances and the inflammatory syndrome concomitant with obesity is related, among other alterations, to the appearance of glomerulosclerosis and tubulointerstitial atrophy. (COWARD and FORNONI, 2015).

    In addition, excess weight is commonly accompanied by other components of metabolic syndrome and insulin resistance, which synergistically can induce the onset of kidney injury or exacerbate pre-existing pathologies. Most of these are possibly compensatory responses to the systemic increase in energy demand (TSUBOI et al., 2017). Its association with the rate of progression of chronic kidney disease (CKD) is related to many factors such as hyperfiltration, glomerular hypertension and hyperactivation of the anintho-angiotensin-aldosterone system (AAR) (BOUQUEGNEAU, 2015).

    The condition called obesity-related glomerulopathy is characterized by glomerulomegaly, progressive glomerulosclerosis, and declining renal function. The rate of progression to end-stage renal disease (ESD) is slow and once renal damage is established, the disease progresses with the development of proteinuria. The marked difference in the prevalence of obesity compared to the prevalence of kidney disease demonstrates that obesity alone is not a sufficient risk factor for kidney disease. There are other factors that increase individual susceptibility to the disease. (TSUBOI et al., 2017).

    Unsustained weight loss during treatment and recurrence of the disease is often observed, leading to the progression of target organ damage in many of these patients. Research efforts have focused not only on the factors that regulate energy balance, but also on the mechanisms of target organ injury; these are given from physical compression of the organ by excess weight to various pathological pathways (CHAD and HALL, 2016).

    According to population estimates, there are currently 850 million people with kidney disease worldwide, resulting from various etiologies. Its chronic form causes at least 2.4 million deaths annually; in Brazil, around ten million people have the disease. 

6
  • MYRA JUREMA DA ROCHA LEAO
  • Epidemiological profile, risk factors related to breast cancer in patients in Alagoas

  • Líder : CAROLINNE DE SALES MARQUES
  • MIEMBROS DE LA BANCA :
  • CARLOS AUGUSTO DE OLIVEIRA CAVALCANTI
  • ROBERTA LIMA
  • ALINE CAVALCANTI DE QUEIROZ
  • CAROLINNE DE SALES MARQUES
  • FREDERICO THEOBALDO RAMOS ROCHA
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • Data: 30-ago-2021


  • Resumen Espectáculo
  • Abstract: Objective: To analyze the epidemiological profile of cancer patients undergoing treatment for breast cancer in the state of Alagoas, and to investigate the involvement of risk factors and prognoses associated with the disease. Methods: A cross-sectional, retrospective and analytical, with the use of secondary data from medical records, and prospective with the completion of questionnaires applied to patients in outpatient follow-up at Santa Casa de Misericórdia de Maceió/Al.Information contained in the medical records of this institution regarding patients with outpatient breast cancer treated in two periods was collected: January and February 2019 and the corresponding months of this year, and completed forms. Patients in outpatient care were also recruited in a probabilistic manner for convenience and questionnaires were completed. In these forms, the primary variable was breast cancer and secondary variables were: gender, age, address, schooling, histological type, clinical staging and immunohistochemical classification, neoadjuvance, adjuvence, radiotherapy, radical surgery and conservative surgery. To obtain the complementary clinical variables, the questionnaires were applied, containing as additional secondary variables: weight, height, body mass index, family history for cancer, personal history for cancer and benign breast disease, smoking, alcohol consumption, early menarche, late menopause, nullparity, breastfeeding, use of hormonal therapy, use of contraceptive, sedentary lifestyle. This data was transferred to a Microsoft Office Excel 2020 spreadsheet and statistical analysis was used in the SPSS Statistics Version 26 program. The descriptive data were operationalized through tables and graphs, means, frequencies, standard deviation, and inferential statistics with chi-square tests of independence for the analysis of nominal qualitative variables and ordinal qualitative variables and spearman's correlation was used for the analysis of ordinal qualitative variables. Results: A total of 110 female patients (67 forms and 43 questionnaires) were evaluated. The mean age was 52.99 years. Most women were over 50 years of age (55%), followed by 35-50 years (37.6%) and eight (7.3%) patients were under 35 years of age. For the most part (51%) the patients were from the interior of the state, single (68%) and had a complete middle education (40%). Regarding topography, fifty-six patients (51.4%) right and 48.6% had tumor on the left. With regard to staging, for the most part (55%) presented staging I or II and 45% had staging III or IV. Among the histological types, Infiltrating Ductal Carcinoma was the most common (97%). In 60% of the cases, radical mastectomy was the treatment instituted. 2019 was the year in which most surgeries occurred (27.3%), followed by 2020 (24.5%) and 2018 (11.8%). Neoadjuvant chemotherapy was used in 46% of patients, while adjuvant in 51.6% of cases. Forty-five patients (61.6%) radiotherapy, 10% used anastrazole, 27.7% tamoxifen and 15% Herceptin. Among the risk factors, alcohol consumption was the most found (27%), followed by obesity (17.3%) and sedentary lifestyle (16.4%). Of the total number of patients evaluated, lactation was identified in 27.3% (n=30), in addition, only 2.7% of the patients evaluated were nulliparas. Regarding the histological subtype, luminal subtype B was the most common in patients under 35 years of age, as well as in patients aged between 35 and 50 years. In the population over 50 years of age, the luminal subtype A was the most frequent. Conclusions: The data of the present study corroborate those found in the literature, presenting modifiable risk factors (obesity, sedentary lifestyle, alcohol consumption, use of oral contraceptives), present in this population, but not mostly. A curious fact is the finding of breastfeeding in most women who had breast cancer, considered a protective factor. Thus, it is considered that the knowledge of the epidemiological profile of a disease, such as breast cancer, helps health professionals regarding the characterization of a target population and, consequently, regarding the elaboration of targeted educational strategies, with preventive and self-care measures.

7
  • LAIS QUINTILIANO PEDROZA
  • Study of new inflammatory biomarkers and their relationship with renal involvement in Systemic Lupus Erytheamsus.

  • Líder : THIAGO SOTERO FRAGOSO
  • MIEMBROS DE LA BANCA :
  • FLAVIO TELES DE FARIAS FILHO
  • MERCIA LAMENHA MEDEIROS
  • ROBERTO CORDEIRO DE ANDRADE
  • RODRIGO PEIXOTO CAMPOS
  • THIAGO SOTERO FRAGOSO
  • VALFRIDO LEAO DE MELO NETO
  • Data: 21-sep-2021


  • Resumen Espectáculo
  • Systemic lupus erythesus (SLE) is one of the most prevalent autoimmune rheumatologic diseases in the population, especially affecting young adults of economically active age.

    The disease is characterized by the presence of multiple autoantibodies, compromising different organs and systems (FREIRE; SOUTO; CICONELLI, 2011). Individuals of all ethnic groups may be affected, being more common in black individuals. The disease predominantly affects women, with a rate ranging from 4 to 13 women for each man (PETRI, 2002).

    The manifestations of the disease are heterogeneous, ranging from laboratory abnormalities detectable to inflammation and multiple organ failure (ARRIENS et al., 2017).

    General constitutional symptoms such as asthena, fever and weight loss are common in SLE (HOCHBERGt al., 2016). Edermatological lesions are very frequent and polymorphous, involving skin, vessels and mucous membranes. Cutaneous vasculitis occurs in about 20-30% of patients and can cause nail damage, ulcerations, and gangrene of digital extremities. Joint involvement is common, preferably compromising metacarphalangeal, proximal interphalangeal, knees and wrists, usually symmetrically. Cardiovascular involvement is characterized mainly by a pancarditis.

    There is evidence of clinical renal impairment in 50% of patients. In renal involvement by SLE can occur in several compartments including tubules, interstice, vessels and glomeruli, the latter being the most related to the symptomology in general presented by patients (MARKOWITZ; D'AGATI, 2009). Glomerular disease in SLE may present varying classes of severity with risk of death in some cases. Renal biopsy is the standard procedure used to assess the degree of activity and chronicity related to glomerulopathy. However, in some cases for technical and/or clinical reasons (e.g. increased risk of bleeding) this is not performed using in these cases of treatment based on clinical and laboratory markers already well established for evaluation of renal function such as serum creatinine and creatinine clearance in addition to the 24-hour urine protein dosage to conduct therapy (HOCHBERG et al., 2016; KLUMB et al., 2015). Thus, the evaluation of inflammatory biomarkers that may be related to the degrees of disease activity may be of great importance in the diagnostic and therapeutic arsenal aimed at the patient.

8
  • THIAGO JOSE NASCIMENTO DE SOUZA
  • Study of Suicidal Association and Psychological Pain in Pacients with Systemic Erythematosus lupus.

  • Líder : VALFRIDO LEAO DE MELO NETO
  • MIEMBROS DE LA BANCA :
  • JORGE ARTUR PECANHA DE MIRANDA COELHO
  • JULIANA CELIA DE FARIAS SANTOS
  • MARIA CICERA DOS SANTOS DE ALBUQUERQUE
  • RANER MIGUEL FERREIRA POVOA
  • TIAGO GOMES DE ANDRADE
  • VALFRIDO LEAO DE MELO NETO
  • Data: 22-sep-2021


  • Resumen Espectáculo
  • Systemic Lupus Erythematosus (SLE) is a chronic inflammatory disease that affects connective tissue, its etiology is multifactorial and is characterized by the involvement of several organs and systems. The clinical manifestations are diverse, being able to involve any organ or system, simultaneously or in isolation, at any stage of the pathology. Among other manifestations, there are mood disorders, which are very variable and can leave the individual depressed, melancholic, sad, hopeless, with a feeling of isolation and rejection. It is necessary to consider stress and psychosocial suffering in its onset, evolution, aggravation and possible control, which may lead the individual to have suicidal behaviors. This is a descriptive cross-sectional study with quantitative methodology that aims to investigate the presence of suicidal behavior and other psychiatric disorders and their relationship with patients with SLE, where it was carried out at the rheumatology outpatient clinic of Universitary hospital Prof. Alberto Antunes (HUPAA) of the Federal University of Alagoas in the city of Maceió. The sample is non-probabilistic for convenience, which consisted of patients in outpatient care. Data collection took place through the application of a sociodemographic and clinical questionnaire, diagnostic instruments such as: Mini International Neuropsychiatric Interview (MINI 7.0.2), as well as instruments of intensities such as Barratt's Impulsivity Scale (BIS-11), Aggression Scale Buss-Perry (AQ), Beck Depression Inventory (BDI), Beck Hopelessness Scale (BHS), Pittsburgh Sleep Quality Index (PSQI), Quality of Life Scale (SF-36) and the Scale psychological pain (Psychache Scale).

     

9
  • LUCAS NOVAIS BOMFIM
  • Analysis of the main clinical and laboratory alterations and computed tomography scans in patients infected with sars-cov-2 in Maceió-Alagoas

  • Líder : MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • MIEMBROS DE LA BANCA :
  • CELIA MARIA SILVA PEDROSA
  • GERALDO BEZERRA DA SILVA JÚNIOR
  • MERCIA LAMENHA MEDEIROS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • SAMIR BUAINAIN KASSAR
  • VALFRIDO LEAO DE MELO NETO
  • Data: 22-sep-2021


  • Resumen Espectáculo
  • The Coronavirus 19 pandemic (SARS-CoV-2) has brought great advances in research in medical areas worldwide, with a growing search for more appropriate diagnostic methods, effective treatments and preventive methods, such as vaccination, for example. The precise diagnosis of COVID-19 infection is made by laboratory examination known as RCT-PCR, which analyzes the presence of the virus in the nasal and oral cavities. Computed tomography of the chest has been assisting in the early diagnosis of pulmonary alterations resulting from COVID-19 and collaborates with the multidisciplinary team in the evaluation of the severity of the patient, favoring a more adequate conduction for each situation. Main objective is to correlate the main clinical, laboratory and imaging alterations in Computed Tomography in patients confirmed by SARS-COV-2 infection. One of the private hospitals in the state of Alagoas has a registry of 3456 patients confirmed for infection with COVID-19 through RT-PCR between March and December 2020, of these only 1568 have ct scans in the imaging database. Of these 1568, 430 patients were randomly selected and respecting the monthly proportionality of cases, but 40 were excluded by age (06), incomplete laboratory data (32) and for having imaging exams (tomography) unavailable (02), totaling a sample of 390 patients. Of the 390 patients analyzed, 194 were male and 196 female and the mean age of the sample studied was 49.8 years (between 18 and 95 years). The symptoms presented at the time of medical consultation were dry cough (66.9%), fever (58.9%), dyspnea (45.6%), headache (45.1%), myalgia (36.4%), odinofagia (34.8%), asthenaism (31 anosmia (28.9%), ageusia (27.1%), runny nose (23.5%), diarrhea (21.0%), chest pain (13.5%), dizziness (5.1%), abdominal pain (3.8%), productive cough (2.0%), conjunctivitis (1.5%) and rash (1.0%). In conclusion, SARSCOV-2 infection has been increasingly studied for a better understanding of its behavior in the body, in order to promote better care to the population with reduced mortality.

10
  • AVHA CLARICE PAIXAO SOARES
  • Impact of the pandemic by COVID-19 on mental health and quality of life of high-risk pregnant women treated at HUPAA/UFAL

  • Líder : MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • MIEMBROS DE LA BANCA :
  • JOSE RAMON RODRIGUEZ ARRAS LOPEZ
  • CLAUDIO TORRES DE MIRANDA
  • ISABELA KARINE RODRIGUES AGRA DOS SANTOS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • SAMIR BUAINAIN KASSAR
  • TELMO HENRIQUE BARBOSA DE LIMA
  • Data: 23-sep-2021


  • Resumen Espectáculo
  • Introduction: The pandemic caused by the new coronavirus (COVID-19) generated several health and social isolation measures promoted by the authorities in several countries. Pregnant women were included as the population group most susceptible to COVID-19 due to several aspects, causing in this group a greater rigidity in social distancing, promoting even more fear and anxiety in a notoriously more fragile period of women's lives. It is known that the high prevalence of perinatal depression is influenced by risk factors, including increased somatic symptoms, exposure to intimate partner violence, little social support and unwanted pregnancy, and its prevalence is estimated at 19 to 25% in underdeveloped or developing countries. Objective: to evaluate the impact of the pandemic by COVID-19 on the mental health of high-risk postpartum pregnancy patients attended at the high-risk obstetrics service of the Professor Alberto Antunes University Hospital (HUPAA/UFAL), measuring the frequency of mental disorders and suicidal ideation and scoring the scores of different quality of life domains. Methodology: Two standardized and validated questionnaires were applied, the SF-36 and the MINI version 7.0.2, in addition to a form developed exclusively for this research to investigate socioeconomic aspects in voluntary postpartum patients up to 48 hours postpartum hospitalized in the obstetrics service of HUPAA/UFAL. Seventy-three puerperum were invited for research, 37 signed the TCLE, one of which removed the term, with an initial sample of 36 patients. After re-evaluation of inclusion criteria, 02 patients were removed from the sample, finishing the sample in 34 individuals. Initial results: In the initial analyses, a prevalence of 23.5% of mental disorders was identified in the interviewed patients, with major depression predominated as the main diagnosis. Suicidal ideation was identified in 11.8% of the sample. Regarding quality of life scores, there was a statistically significant association between patients with some mental disorder with lower scores in the various domains of the SF-36. The analyses performed so far show that they are in accordance with the literature.

11
  • EMMANUELE SANTOS ALBUQUERQUE
  • Adherence to Drug Therapy in patients with Systemic Lupus Erytheamstreated treated at a University Hospital

  • Líder : THIAGO SOTERO FRAGOSO
  • MIEMBROS DE LA BANCA :
  • LUCIANA OLIVEIRA DOS SANTOS
  • ALINE CAVALCANTI DE QUEIROZ
  • CLAUDIO TORRES DE MIRANDA
  • FLAVIO TELES DE FARIAS FILHO
  • JULIANA CELIA DE FARIAS SANTOS
  • THIAGO SOTERO FRAGOSO
  • Data: 24-sep-2021


  • Resumen Espectáculo
  • INTRODUCTION: One of the points considered most important for the success of a treatment is adherence to the prescribed therapy. The World Health Organization (WHO) points out that patients with chronic diseases are potential candidates for inadequate follow-up of the proposed drug therapy, which hampers the achievement of the desired results, putting in doubt, for example, its efficacy. In the group of chronic diseases is Systemic Lupus Erythematosus (SLE), which also corresponds to an inflammatory, multisystemic, immune-mediated disease. Low adherence to SLE can lead to disease activity, causing organic damage, increasing the number and length of hospital stays, reducing the quality of life of this patient, culminating in a high risk of morbidity and mortality, work and school absenteeism, generating a great impact psychosocial and economic aspects of patients and their social environment. OBJECTIVES: To verify the prevalence of Adherence to Drug Therapy (TMJ) among patients with Systemic Lupus Erythematosus (SLE) and the factors associated with it. MATERIAL/METHOD: exploratory, descriptive, cross-sectional study, carried out at the SLE Clinic of the Rheumatology Service of Hospital Universitário de Alagoas, Brazil. The sampling method used was non-probabilistic for convenience and the sample consisted of 116 patients in outpatient care. Data collection took place through the application of the Sociodemographic Questionnaire, the Brazilian Economic Classification Criterion of ABEP, MAT (Treatment Adherence Measure), SF-12, SLICC, SLEDAI and analysis of medical records. Descriptive and inferential statistical analysis was performed. RESULTS: Demographic and social data showed that 64.7% of the sample declared themselves brown, with a mean age of 36.5 (± 11.30), with the majority being female (95.7%). Regarding the sample's schooling, 50.9% had completed high school; the income of 46.6% of the sample being approximately up to a minimum wage. Regarding the treatment regimen, 58.6% of the sample had polymedication. The prevalence of adherence was 55.2%. The statistical tests used in this study showed an association between the variable adherence and time since diagnosis (p <0.033), headache (p <0.014), physical exercise (p <0.005) and difficulty following the treatment (taking medication and / or performing exams and / or going to consultations) (p <0.000). CONCLUSION: The study data indicated that adherence to drug therapy in SLE is a complex and multifactorial phenomenon. The identification and analysis of the factors that can lead to non-adherence to drug therapy, can allow the development of health actions aimed at reducing barriers in treatment, as well as care costs and, mainly, promoting better perspective and quality of life for the patient.

12
  • MAYARA LEITE ALVES DA SILVA
  • Study of association between suicidal behavior and psychological pain in patients with fibromyalgia

  • Líder : VALFRIDO LEAO DE MELO NETO
  • MIEMBROS DE LA BANCA :
  • VALFRIDO LEAO DE MELO NETO
  • SAMIR BUAINAIN KASSAR
  • TIAGO GOMES DE ANDRADE
  • JORGE ARTUR PECANHA DE MIRANDA COELHO
  • MARIA CICERA DOS SANTOS DE ALBUQUERQUE
  • ROBERTO CORDEIRO DE ANDRADE
  • Data: 27-sep-2021


  • Resumen Espectáculo
  • This study aims to investigate an association between suicidal and psychological behavior in patients with Fibromyalgia FM. This is an observational, cross-sectional study with a quantitative approach that was carried out at the rheumatology service and at the pain outpatient clinic of Hospital Universitário Prof. Alberto Antunes (HUPAA) - Federal University of Alagoas in the city of Maceió (Alagoas). The sample is non-probabilistic for convenience that was found by patients in outpatient care. Data collection took place from the application of the sociodemographic and clinical questionnaire, diagnostic instruments such as Mini International Neuropsychiatric Interview (MINI 7.0.2) and FM diagnostic scale according to the criteria of the American College of Rheumatology (ACR), as well as instruments of intensities such as Psychic Scale (Psychological Pain Scale), Barratt's Impulsivity Scale (BIS-11), Buss-Perry Aggressiveness Scale (AQ), Beck's Depression Inventory (BDI), Beck's Hopelessness Scale (BHS), Pittsburgh Sleep Quality Index (PSQI), Quality of Life Scale (SF-36). Results: The average age among patients is approximately 50 years. The mean of the (PSQI) score was 13, since the total score between 5 and 10 the patients are under sleeping problems and above of 10 appear sleep disorder. From the sample, (88.6%) of the patients had a higher number. The mean scores of psychological pain, aggression, impulsivity and hopelessness are 35.26 (± 12.39), 2.74 (± 0.66), 75.11 (± 13.11), 9.57 (± 5.12). Conclusion: The prevalence of major depression and bipolar affective disorder among the studied fibromyalgia women is high compared to the general population, as well as the prevalence of sleep disorder and the impulsivity and aggression scores were higher than the general population.

13
  • YARA JANAINA PORTO RIBEIRO
  • Analysis of the reduction of glomerular filtration rate after acute renal injury in the elderly

  • Líder : RODRIGO PEIXOTO CAMPOS
  • MIEMBROS DE LA BANCA :
  • ALINE CAVALCANTI DE QUEIROZ
  • CAROLINNE DE SALES MARQUES
  • DANIELLA BEZERRA DUARTE
  • FLAVIO TELES DE FARIAS FILHO
  • JULIANA CELIA DE FARIAS SANTOS
  • RODRIGO PEIXOTO CAMPOS
  • Data: 28-sep-2021


  • Resumen Espectáculo
  • Introduction Patients with Acute Renal Injury (AKI) have a higher risk of death and development of chronic kidney disease (CKD). It is essential to evaluate the glomerular filtration rate (GFR) in patients who had AKI, especially in the elderly population. There are still few studies that have evaluated GFR according to the severity of AKI. Objective: To analyze the effect of AKI in reducing the glomerular filtration rate in the elderly after 1 year in a tertiary hospital. Methodology: This study is a retrospective cohort conducted in a tertiary hospital. We collected data from patients with acute kidney injury aged 65 years or over who were evaluated by the nephrology service from January 1, 2012 to December 31, 2018. Only those who had at least one serum creatinine dosage after one year of aki development were included. GFR was calculated by ckd-epi formula in ml/min/1.73m2. Patients diagnosed with stage 5 chronic kidney disease (gFR estimated less than 15 ml/min/1.73m2), renal transplant recipients and those who died during hospitalization were excluded. All data were collected through the review of electronic medical records. We analyzed the mean GFR in time zero (T0) and 360 days (T1). Results: A total of 125 patients were included. We observed that the mean GFR of patients between 65 and 80 years in T0 was 60.5 ± 22.11 and in T1 of 46.6 ± 24.5 (reduction of 13.92, p<0.0001) and in patients >80 years in T0 it was 55.6 ± 22.1 and in T1 37.2 ± 20.5 (reduction of 18.3, p<0.00001). Patients with AKIN 1 had a mean reduction in GFR of 10.7 (p=0.002), AKIN 2 of 15.6 (p<0.001) and AKIN 3 of 22.3 (p< 0.00001) between T0 and T1. Patients who had GFR>60 ml/min/1.73m2 had a mean reduction in GFR of 25.02 (p<0.00001) and those with GFR< 60 ml/min/1.73m2 of 7.8 (p=0.0008). patients in >80 years and those who achieved AKIN 3. In our analysis, the reduction of GFR was more pronounced in those patients with GFR >60 ml/min/1.73m2.

14
  • TADEU PEIXOTO LOPES
  • Evaluation of the prevalence of chronic kidney disease in patients with chronic obstructive pulmonary disease.

  • Líder : RODRIGO PEIXOTO CAMPOS
  • MIEMBROS DE LA BANCA :
  • ALYSSON WAGNER FERNANDES DUARTE
  • CARLOS ALBERTO DE CARVALHO FRAGA
  • JUSSARA ALMEIDA DE OLIVEIRA BAGGIO
  • MERCIA LAMENHA MEDEIROS
  • REGINALDO JOSE PETROLI
  • RODRIGO PEIXOTO CAMPOS
  • Data: 29-sep-2021


  • Resumen Espectáculo
  • The consonance between Chronic Kidney Disease (CKD) and Chronic Obstructive Pulmonary Disease (COPD), two age-related conditions, has fundamental clinical implications and prognosis. The age effect on renal and pulmonary function increases the complexity of the interaction between the kidney and lung. The aim of this trial is to clarify the pathogenic mechanisms that establish COPD associated with increased prevalence of CKD, since there are several gaps in lung-kidney interaction, which requires further research for such analysis.

    A cross-sectional observational study was conducted with patients previously diagnosed with Chronic Obstructive Pulmonary Disease (COPD) from the Professor Alberto Antunes University Hospital (HUPAA) in Maceió-AL, northeastern Brazil, from September 2020 to March 2021. specific symptom questionnaire (MMRC) in addition to the analysis of the last spirometry. After data collection, these patients were categorized and divided according to the gold 2019 classification groups (A, B and C/D). Serum creatinine, creatinine and albumin were dosed in an isolated urine sample in order to estimate the glomerular filtration rate using the ckd - EPI 2009 formula and to define the presence of albuminuria (> 30mg/g albumin/creatinine).

    There were 45 patients analyzed in our study, of this total, 24 were classified as GOLD A, 13 men and 11 women, with ages ranging from 53 to 83 years, 4 diabetics, 11 hypertensive patients, mean GFR 75.3 ml/min/1.73 m2 and mean microalbuminuria of 33.4 mg/dl. In GOLD B were 7 men and 2 women, ages ranging between 53 and 90 years, 2 diabetics, 7 hypertensive patients, mean GFR of 74.2 ml/min/1.73 m2 and mean microalbuminuria of 152.8 mg/dl.

    In the GOLD C/D group, we classified 9 men and 3 women, ages ranging from 55 to 88 years, 1 diabetic, 8 hypertensive, mean GFR of 75.7 ml/min/1.73 m2 and mean microalbuminuria of 149 mg/dl.

    The results obtained when we evaluated the GOLD relationship with glomerular filtration rate was not significant, but the GOLD relationship with microalbuminuria was significant, evidencing higher in the GOLD B and GOLD C/D groups compared to GOLD A.

15
  • TERESA AMELIA SANTOS DA SILVA
  • Nutritional Status of High Risk Pregnant Women and their Relationship with clinical profile and quality of life.

  • Líder : JULIANA CELIA DE FARIAS SANTOS
  • MIEMBROS DE LA BANCA :
  • JULIANA CELIA DE FARIAS SANTOS
  • CLAUDIO TORRES DE MIRANDA
  • MERCIA LAMENHA MEDEIROS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • RAPHAELA COSTA FERREIRA LEMOS
  • TELMO HENRIQUE BARBOSA DE LIMA
  • Data: 30-sep-2021


  • Resumen Espectáculo
  • Worldwide, there has been an increase in the prevalence of overweight and obesity. According to 2019 IBGE data, 1.6% of the adult population had weight loss, 60.3% were overweight, with a prevalence of obesity in 25.9%. Several studies evaluate the effects of maternal nutritional status on gestational complications and unfavorable outcomes for maternal and newborns, but few studies address this assessment in the context of high-risk pregnancies. In addition to the clinical status, the quality of life of the pregnant woman could be impacted during the gestational period, since it is a time of many changes. Objective: to evaluate the nutritional status of high-risk pregnant women attended at the Professor Alberto Antunes University Hospital and its relationship with the occurrence of gestational complications, outcomes for the newborn and quality of life of pregnant women. Results: the prevalence of underweight in the sample studied was 5.66%, overweight was 73.58%, 33.96% overweight and 39.62% obese. The percentage of pregnant women with insufficient weight gain was 20.75% and excessive gain was 49.06%. There was a higher prevalence of complications related to hypertensive syndrome in obese patients and higher occurrence of infectious complications and prematurity in those with low weight. The weight of the NB at birth showed a difference between the groups, with a mean lower weight in the groups of low weight and eutrophy, while the mean higher weight occurred in the obese group. There were no differences in quality of life scores in relation to nutritional status. Conclusion: The high prevalence of obesity in high-risk pregnant women and the association between maternal nutritional status and the occurrence of conditions that interfere with maternal and newborn perinatal outcomes highlights the importance of measures aimed at improving the nutritional status of women prior to pregnancy and during prenatal follow-up.

16
  • MÁRCIO THOMAZ DOS SANTOS VARJÃO
  • Leishmanicide potential of Antarctic microbial products: pharmacological evaluation of bacterial pigmented extracts and systematic review of anti-Leishmania activity of fungal metabolites

  • Líder : ALINE CAVALCANTI DE QUEIROZ
  • MIEMBROS DE LA BANCA :
  • ALINE CAVALCANTI DE QUEIROZ
  • ANA CAROLINA SANTANA VIEIRA
  • CAMILA DE BARROS PRADO MOURA SALES
  • CAROLINNE DE SALES MARQUES
  • MARIANA DA SILVA SANTOS
  • MICHELLE JACINTHA CAVALCANTE OLIVEIRA
  • Data: 30-sep-2021


  • Resumen Espectáculo
  • Diseases like leishmaniasis remain neglected by the pharmaceutical industry. Consequently, the treatment for this disease is out of date, leaving countless affected individuals unattended. To reverse the impact of this abandonment, it is essential to search for new prototypes of safer drugs for the treatment of leishmaniasis. Therefore, the bioprospecting of natural products, especially microbial products from extreme environments, represents an excellent starting point. From this perspective, the present study investigated the leishmanicidal activity of extracts of bacteria isolated from Antarctica, as well as carried out a systematic review about the leishmanicidal activity of fungal metabolites. In all, eight bacterial isolates obtained from soil samples and Antarctic lichens were grown in nutrient broth for seven days at 15 ° C for biomass production. The intracellular pigmented metabolites were extracted with methanol and subsequently the obtained extractive solutions were dried in a vacuum desiccator. The cytotoxicity of the extracts will be evaluated against the lineage of macrophages J774.A1 by means of the tetrazolium salt reduction (MTT) assay and the antiparasitic action evaluated on macrophages infected with Leishmania spp. as to the rate of infection and the multiplication of intracellular parasites. The systematic review aimed to identify through the PubMed, Lilacs and Scielo databases, the existing evidence in the literature regarding the efficacy of the leishmanicidal activity of fungal bioproducts that represent new starting points for the advancement of leishmaniasis pharmacotherapy. Among the selected studies, 53 (89.8%) carried out exclusively in vitro assay, while only 2 (3.4%) carried out exclusively in vivo assay. Another 4 (6.8%) performed the two analysis methodologies (in vitro and in vivo). Together, the evidence reported by the publications gathered in the review, indicate in the prospecting of fungal bioproducts a promising path in the fight against leishmaniasis.

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