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Disertaciones |
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1
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LILYANA WALESKA NUNES ALBUQUERQUE
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Development of a new diagnostic method and in vitro evaluation of a new therapeutic strategy for leishmaniasis
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Líder : ALINE CAVALCANTI DE QUEIROZ
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MIEMBROS DE LA BANCA :
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ALINE CAVALCANTI DE QUEIROZ
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ANDRESSA LETICIA LOPES DA SILVA
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CAMILA DE BARROS PRADO MOURA SALES
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FABIANA ANDREA MOURA
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GLAUBER JOSE FERREIRA TOMAZ DA SILVA
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JULIANA CELIA DE FARIAS SANTOS
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Data: 26-ene-2023
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Resumen Espectáculo
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Introduction: Leishmaniasis is a neglected disease that, despite its epidemiological importance, still has limitations in terms of diagnosis, either because of the gold standard using an invasive biological sample collection method, or because of the variation in sensitivity, requirement of laboratory structure, highly qualified technicians. or high cost of other methods used. Objective: The present study aims to carry out a technological prospection of patents that indicate new immunodiagnostic methods for human tegumentary leishmaniasis in the last 10 years, aiming at diagnostic alternatives with a greater degree of sensitivity and specificity, of easy utilization and lower cost.Methods: This review of patent literature used six patent databases: The LENS, WIPO, EPO, USPTO, Patent Inspiration, Google patents and INPI.Results: 630 patents were analyzed, of which 13 were selected according to combinations of descriptors and study criteria. The information gathered here covered the main characteristics of the immunodiagnostic methods evaluated. Conclusion: In conclusion, the present prospective study indicated the biotechnological advances in the immunodiagnosis of cutaneous leishmaniasis in the last decade, especially in Brazil, which has the largest number of patents on new methods for the immunodiagnosis of cutaneous leishmaniasis. However, despite being a neglected disease, in the last three years no patent document on the subject was found, which raises a concern about the diagnosis of leishmaniasis.
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2
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VANESSA MIRANDA PEREIRA FAUSTO
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METABOLOMIC BIOMARKERS AS PREDICTORS OF CARDIOVASCULAR RISK IN PATIENTS WITH SYSTEMIC LUPUS ERYTHESUM
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Líder : THIAGO SOTERO FRAGOSO
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MIEMBROS DE LA BANCA :
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ANTONIO LUIZ RIBEIRO BOECHAT
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AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
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FLAVIO TELES DE FARIAS FILHO
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MICHELLE JACINTHA CAVALCANTE OLIVEIRA
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RODRIGO PEIXOTO CAMPOS
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THIAGO SOTERO FRAGOSO
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Data: 27-feb-2023
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Resumen Espectáculo
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INTRODUCTION: Systemic Lupus Erytheamus is a chronic, immunomediated inflammatory disease, where the loss of immune regulation and the presence of autoantibodies result in multiple organ involvement. Lupus patients have increased cardiovascular risk compared to healthy people of the same sex and age. Existing methods of cardiovascular risk screening are not sufficient for patients with Systemic Lupus Erytheamus. OBJECTIVES: To evaluate metabolomic biomarkers that may be predictors and aid for cardiovascular risk assessment in this population. MATERIALS AND METHODS: Observational study and cross-sectional cohort. The sample was selected by convenience, composed of patients with SLE by the Rheumatology outpatient clinic of the Professor Alberto Antunes Hospital, a tertiary hospital in a northeastern capital. Patients of both sexes over the age of 18 years were included and signed the Free Consent and Informed Consent Form (Informed Consent). For the comparative analysis, the sample of patients control by convenience was also selected, composed of people of both sexes aged over 18 years who did not have autoimmune disease. These control patients also signed the Free Consent and Informed Consent Term (TCLE). Blood examination was collected at the Laboratory of the Professor Alberto Antunes University Hospital and a sample was sent to the Chemistry Laboratory of the Federal University of Alagoas for metabolomics evaluation. Subsequently, a statistical comparison of patients with Lupus and controls will be performed.
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3
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TENILDO LOPES
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PATIENT WITH SISTEMIC LUPUS ERYTHESIS AND ITS ASSOCIATION WITH FATIGUE, CLINICAL PARAMETERS AND DRUG THERAPY
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Líder : THIAGO SOTERO FRAGOSO
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MIEMBROS DE LA BANCA :
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FLAVIO TELES DE FARIAS FILHO
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MARIA DO SOCORRO MENESES DANTAS
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MERCIA LAMENHA MEDEIROS
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MICHELLE JACINTHA CAVALCANTE OLIVEIRA
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THIAGO SOTERO FRAGOSO
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VALFRIDO LEAO DE MELO NETO
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Data: 08-mar-2023
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Resumen Espectáculo
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INTRODUCTION: Systemic Lupus Erythesus (SLE) is an autoimmune disease that affects several organs and is associated with fatigue. In addition, the patient of this disease suffers losses in daily activities with impairment in functional capacity with low level of muscle strength and postural instability. In addition, with the evolution of the disease, there is an increase in the risk of fall and low physical conditioning. OBJECTIVES: To verify the level of fatigue in patients with systemic lupus erythesus; Evaluate the level of handgrip strength in patients with systemic lupus erytheamsum; Analyze functional capacity in patients with systemic lupus erythesus; Evaluate the strength of the lower limbs in patients with systemic lupus erythesus; Assessing the handgrip strength in patients with systemic lupus erythesus MATERIALS AND METHODS: An observational, cross-sectional study was performed in patients with confirmed diagnosis Systemic Lupus Erytheamus (SLE) followed at the Professor Alberto Antunes University Hospital – Federal University of Alagoas in the city of Maceió-AL. The sample was composed of people from 18 years of age, in which all signed the Free Consent and Informed Consent Term (TCLE). The variables of analysis were: anthropometric measurements such as weight, height and BMI; systemic lupus erithematosus disease activity index); functional capacity through handgrip tests, sitting and lifting of the chair 5 times and static balance; verification of the presence of fatigue through the Fatigue Severity Scale; verification of covid-19 contagion and post-covid-19 sequelae through self-report and socio-demographic questionnaire. Descriptive analyses were performed using mean, standard deviation, relative and absolute frequency for continuous variables and percentage for binary variables. The Shapiro-Wilk test was used to verify the normality of the distribution of continuous variables. In the normal condition of the data, the comparison between two means will be made by the t-Student test. In the case of non-normality of the data, the Mann-Whitney test was applied. P< 0.05 values were considered statistically significant. FINDINGS; The sample presented a predominance of 100% female, mean time of disease installation 9.1 years, no patient reported using alcohol or smoking, 23% reported having hypertension and 10% diabetes, mean age of 40.1±12.5, weight 66.2±13.1, BMI 26.0 ±4.9, regarding physical activity practice 75% reported not doing any type of exercise, 80% of the patients revealed to have taken the covid vaccine on average 2.6 ±0.9, among the functional capacity test 92% of the patients were above the cutoff point of 13 seconds in the sit and lift test 5 times, in the static balance test only 10% presented difficulties in the monopedal phase and could not complete the test, in the right handgrip test value in kilos in the right hand 10.0 ±6.3 left hand 9.1 ±5.9, among the verification of the fatigue severity scale the mean value was 35.5 ±16.8, in the items that focus on constant physical performance, obligation, responsibilities, disabilities and in the social and family relationship the mean value was above the cutoff point 4.0, among the medications used were Hydroxychloroquine and Azathioprine CONCLUSION: the results of the present study demonstrate that the presence of fatigue in the activities of daily living of patients with systemic lupus erytheams, has impaired their obligations and responsibilities especially in those who depend on the performance of some physical effort, the presence of fatigue also influences the low level of physical activity increasing body composition and the emergence of new diseases hypertension and diabetes.
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4
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ÍCARO RAPHAEL SOUZA DOS SANTOS
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ASSOCIATION BETWEEN LEVEL OF PHYSICAL ACTIVITY AND CIRCADIAN PREFERENCE IN PATIENTS WITH SYSTEMIC ERYTHESUM LUPUS
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Líder : THIAGO SOTERO FRAGOSO
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MIEMBROS DE LA BANCA :
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ALEXANDRE URBAN BORBELY
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AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
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FLAVIO TELES DE FARIAS FILHO
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MARIA DO SOCORRO MENESES DANTAS
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THIAGO SOTERO FRAGOSO
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VALFRIDO LEAO DE MELO NETO
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Data: 09-mar-2023
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Resumen Espectáculo
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INTRODUCTION: Systemic lupus erithematosus (SLE) is an autoimmune condition of multisystem character associated with significant morbidity and mortality rates. Physical inactivity is highly prevalent in individuals with SLE. The phenotypic expression of an individual’s circadian rhythm or circadian preference is closely related to biological variables, and as a result it might influence the level of physical activity and clinical conditions in a population. OBJECTIVES: This study aimed at determining levels of physical activity and their associations with circadian preferences and clinical parameters in systemic lupus erythematosus. MATERIALS AND METHODS: SLE patients according to ACR’s criteria for diagnosis were included in this research. Physical inactivity was assessed through IPAQ short form. Circadian preference was assessed via MEQ. Disease activity and damage were assessed through modified SLEDAI-2K and SLICC. Data was analysed statiscally considering p < 0,05
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5
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GRAZIELA CYNTIA SILVA SANTOS
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EARLY FEEDBACK AFTER CESAREAN IN A PRIVATE HOSPITAL IN MACEIÓ: IMPACT ON THE HEALTH OF THE MATERNAL-FETAL BINOMIUM
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Líder : FABIANA ANDREA MOURA
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MIEMBROS DE LA BANCA :
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FABIANA ANDREA MOURA
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JULIANA CELIA DE FARIAS SANTOS
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MICHELLE JACINTHA CAVALCANTE OLIVEIRA
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SAMIR BUAINAIN KASSAR
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ALANE CABRAL MENEZES DE OLIVEIRA
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ANDREA MARQUES VANDERLEI FREGADOLLI
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Data: 21-mar-2023
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Resumen Espectáculo
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The international protocol ERAS (Enhanced Recovery After Surgery), published in 2005 on the European continent, brings a series of recommendations backed by scientific evidence for perioperative care and improvements in patient recovery (Eras Society, 2021). Based on this protocol, the ACERTO project – Acceleration Total Post-Operative Recovery - which deals, among others, with issues nutritional supplements in the recovery of the surgical patient and points out measures that reduce postoperative complications and reduce the length of hospital stay, without increase in readmission rates (EDUARDO, 2017) . As recommended by the ERAS protocol for pregnant women (WILSON et al. al., 2018) , in preoperative fasting, women should be encouraged to drink liquids clear (juice without residue, coffee or tea) up to 2 hours before surgery and a light meal can be consumed up to 6 hours before surgery. In the same vein, the Society of Anesthesiology (SMITH et al., 2011) already recommended that children and adults should be encouraged to drink clear fluids up to two hours before elective surgery, including cesareans.
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6
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KAROLINE BÁRBARA DA SILVA OLIVEIRA
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Handgrip strength and corrected arm muscle area as risk factors for clinical outcomes and mortality in patients with chronic kidney disease on hemodialysis
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Líder : RODRIGO PEIXOTO CAMPOS
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MIEMBROS DE LA BANCA :
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FABIANA ANDREA MOURA
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FLAVIO TELES DE FARIAS FILHO
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JULIANA CELIA DE FARIAS SANTOS
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RODRIGO PEIXOTO CAMPOS
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SAMARA BOMFIM GOMES CAMPOS
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Data: 25-abr-2023
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Resumen Espectáculo
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INTRODUCTION: Chronic kidney disease (CKD) negatively affects muscle health with consequent increase in frailty. Especially in patients undergoing hemodialysis (HD), peculiar factors of the pathology and the dialysis process favor the decline in nutritional status, greater fragility and risk of falls and fractures in these patients, negatively impacting quality of life and contributing to a worse prognosis. OBJECTIVES: To investigate the association of muscle strength and muscle mass reduced in patients with CKD on HD and their impact as a risk factor for hospitalizations, cardiovascular events, and mortality. MATERIAL AND METHODS: This is a prospective cohort, carried out with 300 patients between 18 and 80 years of age, in Chronic HD. Muscle strength was measured by handgrip strength (HGS) and muscle mass by the equation estimating the corrected arm muscle area (AMBc). Patients were classified as reduced HGS as HGS<26kg for men and <16kg for women. Those were classified with muscle depletion by AMBc who presented values ≤15th percentile according to sex and age group. The patients were followed for a minimum period of 9 months to observe the incidence of clinical outcomes investigated. For analysis of the association between reduced HGS and AMBc and clinical outcomes, the Kaplan-Meier survival curve and the logrank test were used. A multivariate analysis was also performed using the regression model of Cox proportional hazards presented as hazard ratio (RR) at intervals of 95% confidence (95% CI) and considered significant when p<0.05. RESULTS: Reduced FMF was significantly associated with Mass Index Body (BMI) and type of vascular access (p=<0.05). The reduced AMBc was also associated with BMI (p=0.015), in addition to longer HD time (p<0.001). According to analysis of regression, it was evidenced that HGS and reduced AMBc presented themselves as factors of significant risk for the incidence of hospitalizations (p<0.001) and events cardiovascular (p=0.025). The reduced AMBc is still strongly associated with increased relative risk for mortality (p=0.020). CONCLUSION: Patients with CKD on HD that showed reduced muscle strength and muscle mass measured by HGS and AMBc have a higher risk for the incidence of hospitalizations, events cardiovascular and mortality when compared to patients with HGS and AMBc Normal.
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7
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LARISSA STHEFANE SANTANA DA CUNHA
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Assessment of Covid-19 fear, anxiety and quality of life in chronic renal patients
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Líder : MICHELLE JACINTHA CAVALCANTE OLIVEIRA
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MIEMBROS DE LA BANCA :
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JULIANA CELIA DE FARIAS SANTOS
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MERCIA LAMENHA MEDEIROS
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MICHELLE JACINTHA CAVALCANTE OLIVEIRA
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SAMIR BUAINAIN KASSAR
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THIAGO SOTERO FRAGOSO
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VALFRIDO LEAO DE MELO NETO
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Data: 26-may-2023
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Resumen Espectáculo
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Introduction: COVID-19, a disease caused by Sars-Cov-2 or new Coronavirus since its appearance in Wuhan (China), has aroused fear and apprehension on a global scale due to its rapid spread. The consequences caused by the new Coronavirus were mainly sanitary and psychological, with a cluster of cases of depression, anxiety and domestic violence. Studies conducted in China early in the pandemic identified chronic kidney disease as a risk factor for worsening the disease and mortality in COVID-19 infected patients. Objectives: To evaluate the fear of COVID-19, anxiety and quality of life in the study participants with chronic dialysis and non-dialysis patients. In addition to characterizing the socioeconomic, demographic and clinical profile of the population studied, patients according to the scale of fear and anxious trait, measure anxious trait and fear with clinical and laboratory data and associate quality of life and anxiety disorder in chronic renal patients. Methodology: The research is a cross-sectional study that is being conducted through the application of questionnaires, including the quality of life scale with SF-36 instrument, the State Trait Anxiety Inventory (STAI) and the COVID-19 fear scale. The study is being conducted in chronic renal participants treated at conservative treatment outpatient clinics for chronic kidney disease treated at the Nephrology outpatient clinic of the Prof. Alberto Antunes University Hospital (HUPAA/UFAL). Results: To date, 47 chronic renal patients have been approached, all non-dialysis. Being 22 males and 25 females. The mean age of the participants ranged from 18 to 97 years of age, and most are over 60 years of age. More than 50% of the sample is brown, living in Maceió, has a partner (a) and took the vaccine for COVID-19. The other questionnaires have not yet been analyzed for the scores. Conclusion: With the research it is expected to know whether the fear of COVID-19 decreased in chronic renal patients after vaccination, whether dialysis has higher levels of anxiety than those on conservative treatment and whether the fear of COVID-19 is higher in more inflamed chronic renal.
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8
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KASSIA ALICE ANJOS DE LIMA
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EPIDEMIOLOGICAL APPROACH AND SPACE-TIME DIN MICA OF LEPROSY AND DISABILITIES IN THE POPULATION OF ALAGOAS
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Líder : CAROLINNE DE SALES MARQUES
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MIEMBROS DE LA BANCA :
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ALDA GRACIELE CLAUDIO DOS SANTOS ALMEIDA
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ALYSSON WAGNER FERNANDES DUARTE
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CAROLINNE DE SALES MARQUES
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CHRISTEFANY REGIA BRAZ COSTA
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CLODIS MARIA TAVARES
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JULIANA CELIA DE FARIAS SANTOS
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Data: 30-jun-2023
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Resumen Espectáculo
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Leprosy is caused by Mycobacterium leprae, an alcohol-acid bacillus (ADR) with a predilection for skin and peripheral nerve cells. When in contact with the body, this bacillus can cause neurological dermato lesions and, therefore, physical, functional and psychological impairments. The high incidence of infection is related to ecological factors. From this perspective, studies make important advances in the conception of the natural history of diseases, as they contribute to the understanding of the dynamics of transmission of various pathologies, especially infectious diseases, such as leprosy. This research is part of the larger project "Susceptibility factors to leprosy in Alagoas: epidemiological, genetic and immuno-inflammatory aspects" and its primary objective is to analyze the sand-time epidemiological dynamics of leprosy in the state of Alagoas in the period 2010-2019 and identify factors of associated susceptibility and underreporting. To this do so, this retrospective study quantitative ecological nature involved confirmed cases of leprosy in the years from 2010 to 2019 that have obtained adequate records since the recognition of diagnostic form of the disease and the type of patient's entry into health services until the reported cases, which counted 4739 cases. These were obtained in the from October 2021 to February 2022 in the Injury Information System (SINAN) of the State Secretariat of Alagoas. Based on the Database of the Department of Informatics of the Brazilian Unified Health System (DATASUS). The analysis is being structured in five stages (descriptive, temporal, risk factors and underreporting) with the elaboration of tables, figures and graphs. Through temporal analysis, it was possible to infer that new cases of leprosy in population showed a decreasing trend (PCA/AAPC = - 3.0). However, for new cases of the population under 15 years of age, the disease presented a stationary trend which points out that the elimination of it in the state is more illusory than real. In addition, despite the physical disability in the diagnosis has a decreasing tendency, the indicator of 2 of physical disability in the diagnosis is stationary. This given alert to a possibility of late diagnosis of the disease in the state of Alagoas. Still, it is worth point out that the indicator of degree of physical disability in healing that assesses the quality of attention and follow-up of new cases diagnosed until the completeness of the treatment- has a decreasing trend, which points to a fragility in the leprosy patients in the state. Still at this core, the indicator of grade 2 of physical disability in healing has a steady pattern. It is expected that this research is able to guide the identification of areas with greater vulnerability in Alagoas, as well as the definition of priority areas for tackling the leprosy. It is intended to produce and implement mechanisms to combat pathology and its complications.
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9
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NATHALY ESPERIDIAO DE MELO
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Inflammatory status and levels of impulsivity and aggressiveness as risk factors for suicide
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Líder : VALFRIDO LEAO DE MELO NETO
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MIEMBROS DE LA BANCA :
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VALFRIDO LEAO DE MELO NETO
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ALYSSON WAGNER FERNANDES DUARTE
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AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
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FABIANA ANDREA MOURA
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JULIANA CELIA DE FARIAS SANTOS
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MARIA CICERA DOS SANTOS DE ALBUQUERQUE
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Data: 14-jul-2023
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Resumen Espectáculo
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Introduction: Suicide and suicide-related behaviors represent a major global public health problem, with an estimated 800,000 deaths from suicide each year, making it one of the leading causes of death worldwide. Or suicidal behavior may result from the interaction of many risk factors. Evidence point out the relationship of some biological markers with the sharpening of the including the activation of immunoinflammatory pathways. Among other factors, they may impulsivity and aggressiveness should also be cited. Objectives: Analyze how traces of personality (aggressiveness and impulsivity) and inflammatory state may contribute to for suicidal behavior and scale the impact of brief telecalls on prevention of further suicide attempts. Methodology: Cases of suicide attempt were identified at the State General Hospital (HGE) and the study continued at the Professor Alberto Antunes (HUPAA/UFAL). The following were applied to the questionnaires: Socio-demographic and clinical questionnaire specific to the research; BIS-11 (Barratt Impulsivity Scale) and AQ (Buss-Perry Aggressiveness Scale). The serum levels of inflammatory cytokines (IL-6, TNF-α, IL-8, IL-1β) will be quantified elisa technique. In parallel, patients were contacted by telephone or video call, in brief and regular contacts, with periodicity varying according to the distancing from the attempt. Results: So far eight Patients. Regarding the profile, half of the sample was male, and half of the sex female. Most were non-white ethnicity, marital status without a partner, with teaching incomplete fundamental and active occupational situation and had the unplanned attempt. The mean age of the sample ranged from 22 to 60 years of age. The other questionnaires high scores, showing a high degree of impulsiveness and/or aggressiveness in the sample studied. Conclusion: The data obtained up to the current moment of the search suggest that characteristics such as impulsive and aggressive personality traits increase the risk of suicide. The investigation of suicidal behavior, the sizing of the the problem and the analysis of its determinants, aims to encourage the adoption of more specific to the region studied in order to reduce the rates of death by suicide
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10
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GABRIELA BARBOSA AZEVEDO
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Relationship between domestic violence and suicide attempt among women
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Líder : VALFRIDO LEAO DE MELO NETO
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MIEMBROS DE LA BANCA :
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VALFRIDO LEAO DE MELO NETO
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ALYSSON WAGNER FERNANDES DUARTE
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JULIANA CELIA DE FARIAS SANTOS
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MERCIA LAMENHA MEDEIROS
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MARIA CICERA DOS SANTOS DE ALBUQUERQUE
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VERONICA DE MEDEIROS ALVES
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Data: 18-jul-2023
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Resumen Espectáculo
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Violence against women is a serious global public health problem, particularly in Brazil there are high and increasing cases of domestic aggression against women especially after the Covid Pandemic 19, from childhood to adulthood, this violence causes a series of physical changes and mental disorders that favor ideation and consequent suicide attempts. It is necessary to study the predisposing factors and symptoms more related to these attempts so that objective actions aimed at the impediment are taken and effected. Most suicide attempts are not even attended in health services and it is estimated that before the consumption of lethal fact a person performs previous attempts, in women the attempts are more frequent and this is justified by the use of less lethal methods, while men use more invasive and destructive methods, attempts can be prevented if well addressed, for this, in-depth data on factors involved are needed since the majority is not at least notified, a record that according to Ordinance No. 204 of the Ministry of Health should be done within 24 hours. This study seeks to understand and relate suicide attempts involving patients treated at the largest public emergency hospital in the state of Alagoas with domestic violence. Patients over 18 years of age treated in the emergency department with admission due to self-inflicted injury by suicide attempt will be interviewed, first a sociodemographic questionnaire and psychological pain scale, later the WAST scale validated for screening for domestic violence in women, patients who acentire will be followed at the University Hospital with psychiatric and psychological care, in addition, they will be monitored through teleservices performed by researchers weekly, every two weeks, monthly and quarterly. Between March and July 2022, 4 women were approached (50% of the total sample), all did not have a partner, all have children (2 to 3 children) per woman and all have incomplete elementary school, 85% non-white, half inactive work, family income ranged from 400 to 2400 methods used were burn and injury by misplate, the mean age was 43.25 ranging from 24 to 60 years, one reported prior planning; the Psychological Pain scale showed a high degree of suffering indicated by high scores 44.75, higher than the general 43.85 [±8.68]. The data reveal the difficulties of screening, prevention and treatment of these women since none remained in the study, and it is not possible to apply the WAST questionnaire and subsequent follow-up.
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11
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GLAUCIO MAUREN DA SILVA GERONIMO
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Cardiovascular risk and its correlation with inflammatory biomarkers in dialytic chronic kidney disease.
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Líder : MICHELLE JACINTHA CAVALCANTE OLIVEIRA
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MIEMBROS DE LA BANCA :
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CARLOS ROMERIO COSTA FERRO
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DANIELA MARTINS LESSA BARRETO
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MERCIA LAMENHA MEDEIROS
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MICHELLE JACINTHA CAVALCANTE OLIVEIRA
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SAMIR BUAINAIN KASSAR
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VALFRIDO LEAO DE MELO NETO
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Data: 09-ago-2023
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Resumen Espectáculo
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INTRODUCTION: Patients undergoing hemodialysis (HD) have a cardiovascular risk (CVR) considerably higher than that of the general population, because these individuals end up presenting specific organic and inflammatory changes, in addition to lesions induced by substitutive therapy. In people with chronic kidney disease (CKD), there is also a pro-inflammatory state that contributes substantially to the occurrence of CV events and that induces an acceleration of atherosclerosis. OBJECTIVE: To analyze the CVR and its correlation with inflammatory markers in chronic renal dialysis patients. MATERIALS AND METHODS: This is a cross-sectional observational study, carried out in 3 tertiary hospitals, both public and private, with the application of socioeconomic and clinical questionnaires (gender, age, history, lifestyle habits), laboratory evaluation (hemogram , renal function, lipid profile, C-reactive protein – CRP, ferritin), measurement of inflammatory cytokines (Interleukin 6 – IL-6 and high tumor necrosis factor – TNFα) and measurement of cardiovascular risk score (assessment of global risk score – ERG). RESULTS: A total of 149 participants with CKD on renal replacement therapy (RRT), with a mean age of 58 ± 15 years, with 76 (64.4%) male participants. The adequacy of HD was measured through Kt/V, proving to be satisfactory in the sample. 81 (54.4%) were diabetic, 133 (89.3%) were hypertensive and 32 (21.5%) were obese. 36 participants were known to have heart disease, in addition to 8 others having already presented events resulting from significant obstruction. The CVR scores showed: 105 (70.5%) at high risk and 44 (29.5%) at very high risk.
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12
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EDER DA SILVA ROCHA SANTOS
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Evaluation of leishmanicide activity of microorganism extracts isolated from the Caatinga biome.
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Líder : ALINE CAVALCANTI DE QUEIROZ
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MIEMBROS DE LA BANCA :
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ALINE CAVALCANTI DE QUEIROZ
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AMANDA EVELYN DA SILVA
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CAROLINNE DE SALES MARQUES
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FLAVIANA SANTOS WANDERLEY
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JULIANA CELIA DE FARIAS SANTOS
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MICHELLE JACINTHA CAVALCANTE OLIVEIRA
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Data: 16-ago-2023
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Resumen Espectáculo
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Leishmaniasis is anthropozoonosis caused by protozoa of the genus Leishmania sp. and transmitted by vectors, mainly affect less-favored populations, where the access, medical care and drug therapy are limited, causing serious public health problems. For these reasons too, and are endemic in several countries. Clinical forms are varied, from simple skin lesions that may spontaneously disappear into the visceral form, affecting several organs, and may lead the individual to death. In Brazil, for all forms of leishmaniasis, first-line treatment is pentavalent antimonials Sb(V), currently the available antimonials are N-methyl-glucamina antimoniate (Glucantime) and sodium sybogluconate (Pentostan) for all forms of leishmaniasis, the first-line treatment are pentavalent antimonial Sb(V), currently the antimonial scans are N-methyl-glucamina antimoniate (Glucantime) and sodium sybogluconate (Pentostan), in addition to other second-choice drugs, however, cause a number of side effects and resistance on the part of patients. In view of this, the bioprospecting of natural products is an excellent alternative for production of new antiparasitium drugs, especially bioactive compounds of microorganisms, including bacterial ones. To this end, the present study aims to investigate the leishmanicide activity of extracts of microorganisms isolated from the biome Caatinga. To this do so, five bacterial isolates obtained from liquen samples were nutrient broth for seven days at 25 °C for biomass production. The intracellular pigmented metabolites were extracted with methanol and ethyl acetate, the extractive solutions obtained were dried in a vacuum desiccator. Subsequently, the cytotoxic activity against macrophages of the J774 scan was evaluated. A1 using the MTT method. The anti-promastigote activity of Leishmania amazonensis and Leishmania chagasi, after cultivation of the parasite with the products Natural. It was found that the extracts did not present cytotoxic effect for macrophages.
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13
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CARLOS VIRGILIO ROCHA DE SOUSA SILVA
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Sex Differentiation Disorders 46,XY: screening for pathogenic changes in a case series.
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Líder : REGINALDO JOSE PETROLI
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MIEMBROS DE LA BANCA :
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Fernanda Caroline Soardi
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DELIA MARIA DE MOURA LIMA HERRMANN
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IRAMIRTON FIGUEREDO MOREIRA
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MICHELLE JACINTHA CAVALCANTE OLIVEIRA
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REGINALDO JOSE PETROLI
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Data: 28-ago-2023
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Resumen Espectáculo
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INTRODUCTION: Human sexual development is a process that depends on the integral functioning of several genes and their proteins. Defects in any of these components can cause sex differentiation disorders (DSD). DSDs are congenital conditions in which genetic changes lead to the atypical development of chromosomal, gonadal and/or anatomical sex. The term DDS, adopted from the Consensus Statement on Management of Intersex Disorders, replaces terms considered pejorative and stigmatizing, such as hermaphroditism, pseudohermaphroditism, among others. DSDs may result from variations in genes involved in sexual determination and differentiation, resulting in disorders in gonadal and/or adrenal steroidogenesis, being classified into three groups, according to the karyotype: DDS 46,XY; DDS 46,XX; and DSD associated with chromosomal abnormalities. The DDS 46,XY group, the focus of this work, is characterized by its genetic complexity and phenotypic overlap, where the etiological clarification of these cases is carried out through molecular investigation in genes involved in the determination and differentiation of sex. OBJECTIVE: To perform molecular investigation in a series of cases of 46,XY DSD with no clear etiology. METHODS: From a sample of 58 cases of DDS 46,XY treated at the Clinical Genetics Service of the Professor Alberto Antunes University Hospital (HUPAA), 10 cases were selected for study. For the selection of samples, the following criteria were adopted: previous sequencing of the AR and SRD5A2 genes, no pathogenic changes in these genes and DNA sample available for study. The first stage of the molecular investigation consisted of the sequencing of the HSD17B3 gene by the Sanger method, carried out at the Laboratory of Human Molecular Genetics of HUPAA/UFAL. The second stage, for those cases in which no pathogenic changes in the HSD17B3 gene were identified, the next-generation sequencing (NGS) of 18 genes related to DDS 46,XY, was performed at the Large-Scale Sequencing Center of the Medical School of the University of São Paulo. RESULTS AND DISCUSSION: No pathogenic alterations in the HSD17B3 gene were identified in any of the selected cases. Through the NGS, changes were identified in four cases. In the case of DDSXY-03, hemizygosis of c.89G>T (p.Arg30Ile) alteration in the SRY gene was identified; in the case of DDSXY-04, heterozygosis of the c.565C>T alteration (p.Arg189Cys) in the FKBP4 gene was identified; in the case of DDSXY-07, the heterozygosis of the c.2389C>G (p.Leu797Val) alteration in the DHX37 gene was identified; and in the case of DDSXY-10, the heterozygosis of the c.250C>G alteration (p.Arg84Gly) in the NR5A1 gene was identified. The p.Arg84Gly alteration has not been previously described in the literature, the p.Leu797Val has been described as a variant of uncertain significance, and the p.Arg189Cys alteration has been reported in databases, without reference to the associated clinical condition. The p.Arg30Ile alteration has been described in cases of 46,XY gonadal dysgenesis. In silic predictive analyses revealed that the p.Arg189Cys; p.Leu797Val and p.Arg84Gly are deleterious. According to the literature, the frequency of patients diagnosed with DSD 46,XY without clarified etiology can vary between 33%-80%, even with advances in diagnostic elucidation tools. CONCLUSION: In this study, 40% of the sample presented alterations in genes that are fundamental in the determination/differentiation of sex and remain under investigation of the possible genotype-phenotype correlation. Already 60% remain under investigation aiming at the identification of pathogenic alterations that may justify the phenotype. The functional analysis of the alterations identified here are necessary for the correct genotype and phenotype correlation in each case. The results of this study reinforce the complexity of the etiological elucidation of DSD 46,XY.
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14
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ANALICE SAMPAIO DE ALMEIDA BOMFIM
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Epidemiological profile and clinical status of phenylketonurics in the State of Alagoas
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Líder : SAMIR BUAINAIN KASSAR
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MIEMBROS DE LA BANCA :
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AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
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GRACILIANO RAMOS ALENCAR DO NASCIMENTO
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MERCIA LAMENHA MEDEIROS
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MICHELLE JACINTHA CAVALCANTE OLIVEIRA
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REGINALDO JOSE PETROLI
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SAMIR BUAINAIN KASSAR
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Data: 30-ago-2023
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Resumen Espectáculo
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Phenylketonuria or PKU is an ininate error of amino acid metabolism caused by the mutation of the gene encoding the liver enzyme phenylalanine hydroxylase. This enzymatic defect, related to autosomal recessive inheritance, leads to the accumulation of phenylalanine and its metabolic in the bloodstream and tissues that may imply neurotoxicity and cause irreversible cognitive and neurological damage, including mental retardation, when not diagnosed and treated early. Dietotherapy is the basis of the treatment of this aminoacidopathy and consists of a restrictive diet associated with the use of metabolic formula throughout life. This cross-sectional and observational study has, to date, a sample of 27 participants in follow-up to the Reference Service in Neonatal Screening (SRTN) of the State of Alagoas and aims to analyze the epidemiological profile and clinical situation of alagoan phenylketonurics. The variables surveyed were collected during a face-to-face interview through a questionnaire prepared by the executing researcher followed by physical examination and review of medical records. For the crossing between categorical variables, the chi-square test and fisher's exact test were used when necessary. The differences were considered statistically significant for p < than 5%. Preliminary results reveal that, of the 27 patients, 14 (51.83%) are children under 11 years of age, 70.40% male and 74.10% from the interior of Alagoas. All are single and only 3/27 have some paid activity. Only 29.60% have a family income above 2 minimum wages and 33% receive disease assistance because they have clinical complications and/or cognitive impairment. More than 80% reported clinical complications and 66.70% are classified as mild PKU. Adequate metabolic control was observed in only 22.20% of the study participants. Statistically significant associations were observed between the use of metabolic formula and the presence of clinical complications (p = 0.03) and between cognitive impairment associated with receiving social benefit p < 0.001. The shortage through the state program of acquisition and distribution of these formulas is considered by 74.10% the main factor that impairs the treatment and continuity of treatment. Finally, most alagoan phenylketonurics, although screened and assisted by SRTN/AL, suffer sequelae, avoidable, related to treatment conditions and have compromised health conditions.
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15
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VANNESSA RODRIGUES TELES MAIA
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Antimicrobial and antioxidant profile of metabolites produced by filamentous fungi of the Caatinga biome
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Líder : ALYSSON WAGNER FERNANDES DUARTE
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MIEMBROS DE LA BANCA :
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CAROLINNE DE SALES MARQUES
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ANA PAULA DE ALMEIDA PORTELA DA SILVA
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CAMILA SOUZA PORTO
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ELOIZA LOPES DE LIRA TANABE
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MICHEL RODRIGO ZAMBRANO PASSARINI
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Data: 31-ago-2023
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Resumen Espectáculo
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The advent of antibiotics has revolutionized medical treatments, enabling the development of invasive and surgical techniques with feasibility of recovery and maintenance of the lives of individuals after the procedures, as well as the cure of diseases before fatal. Nevertheless, excessive and irregular use, in addition to genetic mechanisms developed by the microorganisms themselves, brought about microbial resistance, growing problem that has become a global concern in the 21st century, bringing to the fore the need for research for new antimicrobials. The search for new bioactive compounds antimicrobial and antioxidant activities from natural sources have great potential for application in human health. From this perspective, the Caatinga, because it is a biome exclusively Brazilian, with unique climatic characteristics, can host fungi producers of differentiated secondary metabolites. Thus, the objective was to evaluate the antimicrobial and antioxidant potential of secondary metabolites produced by fungi isolated filamentous liqueurs from the Caatinga of Alagoas. To this do so, 35 fungi, produced in solid culture medium Czapek Agar supplemented with glucose 2% by incubation at 30 oC for 15 days. The extraction of secondary metabolites was performed in ethyl ACETATE PA, followed by concentration in rotary stirrer and drying in desiccator coupled to the vacuum pump, followed by production yield evaluation. The extracts were resuspended in DMSO (100 mg/mL) and initially evaluated the antibacterial and antifungal activities by disc diffusion and antioxidant assay by FRAP and DDPH. The next steps will be the assessment of Minimum Injunction Concentrations (MIC) of extracts with antimicrobial activity, in addition to the analysis of the effect of metabolites antimicrobials in biofilms of Staphylococcus aureus and Candida albicans, by means of cell viability test at different concentrations of extracts, as well as by scanning optical microscopy. As partial results, the yield of the extracts ranged from 45.00 mg to 173.00 mg, and the extracts showed different colors such as 15 yellows, seven oranges and two roses. The fungal extract 3UVLFC1 antimicrobial activity against Staphylococcus aureus, while the samples Penicillium sp. (2LCL1), Fusarium sp. (4LCEM2) and 4UVLFC2 demonstrated against Candida abicans. Regarding antioxidant activity, the following samples showed activity identified by frap and DPPH methods: 2LCL1, 4UVLFC2, 3UVLFC7, 4LCEM2, 7UVLFC2, 4UVLFC7, PLC6, Fusarium sp. (ALC3), 1UVLFC7 while the samples then revealed antioxidant activity by frap method: GLC5 and 2UVC8. It can be insated that the fungi isolated from Caatinga liquens have antioxidant potential and which indicates the possibility of biotechnological application.
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16
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AMANDA ALVES FEITOSA BATISTA
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Genetic assessment and surgical treatment of non-syndromic oral clefts in the Brazilian Unified Health System: a multicenter analysis.
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Líder : ISABELLA LOPES MONLLEO
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MIEMBROS DE LA BANCA :
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VERÔNICA OLIVEIDA DIAS
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DEBORA DE PAULA MICHELATTO
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DÉBORA GUSMÃO MELO
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ISABELLA LOPES MONLLEO
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MICHELLE JACINTHA CAVALCANTE OLIVEIRA
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RAFAELA SCARIOT
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Data: 31-ago-2023
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Resumen Espectáculo
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Background: Oral clefts are complex and frequent congenital anomalies. The frequency of dysmorphic signs associated varies from 3% to 63%. The presence of dysmorphic features may change the status from non-syndromic OC (NSOC) to syndromic OC. The diagnosis established through genetic assessment allows treatment planning accordingly to the patient needs and genetic counseling. Treatment is longitudinal and multidisciplinary throughout the health system levels. Timely primary surgery (cheiloplasty and palatoplasty) is essential for successful rehabilitation. A network of 30 craniofacial hospitals accredited by the the Ministry of Health (CFAH) provides specialized treatment in Brazil. However, throughout the country, non-CFAH also operate to the supply-demand disequilibrium. Aim: To investigate the access of patients with NSOC to genetic assessment and surgery in CFAH and non-CFAH. Methods: Quantitative, retrospective, observational, multicenter study with patients with FONS, followed-up from 2008 until 2019 in two CFAH and two non-CFAH members of Brazil's Craniofacial Project. Data was collected during outpatient visits using the CranFlow platform that feeds the Brazilian Database on Craniofacial Anomalies (BDCA). Genetic assessment and cheiloplasty performed after 12 months-old and palatoplasty after 18 months-old were classified as delayed. Odds ratio (OR), Chi-square and Fisher's exact tests were used for statistics with a p-value of 0,05 for significance. Results: Information on 840 patients with NOC feeded the BDCA after genetic assessment. The CFAH and non-CFAH patient rate was 2:1, with the majority attending hospitals in the Northeast of Brazil. Age ranged from 1 day to 61 years-old (4±8) with a predominance of children up to 12 months old. Most lived outside the city where the hospital is located, had low-income families and parents with low education. Cleft lip and palate (CLP) occurred in 54.1%, cleft lip (CL) in 25.4%, and cleft palate (CP) in 20.5% of cases. CLP predominated in males and CP in females (p<0.00); unilateral over bilateral clefts (p<0.00), and left-sided over right-sided clefts (p<0.00). The first genetic assessment was performed before completing 12 months-age in 53.1% of the sample. When comparing patients who had timely genetic assessment with late assessment, there was an increased odds of patients in the delayed group experiencing the following barriers: attending a Non-CFAH (OR=1.8; p<0.000), living outside the hospital's location (OR=1.40; p=0.032) and having illiterate mother (OR=11.72; p<0.000) and father (OR= 3.67; p<0.000). Due to the lack of information on the status of surgical treatment in the BDCA, 331 (39.4%) patients were excluded from this analysis. Among the remaining 509, 261 (51.3%) have had surgical delay, 170 had been timely repaired and 78 were into the time-window for surgery. Summing up there were 431 patients timely-repaired, late repaired and late non-repaired for whom 666 surgeries were needed. However, 418 surgeries were overdue, 219 of which were palatoplasties. When comparing patients who had timely surgery with late surgery, there was an increased odds of patients in the delayed group experiencing the following barriers: attending a Non-CFAH (OR=2.7; p<0.000) from the Northeast (OR=3.93; p<0.000), being in a low-income family (OR=2.32; p=0.005), and having parents with low education (mother: OR=15.11; p<0.000; father: OR=3.53; p=0.001). There was a statistically significant increased odds of patients who needed palatoplasty compared to those who needed cheiloplasty (OR=1.8; p<0.000). Conclusion: Clinical-genetics characteristics of the sample corroborate the literature on the epidemiology of NSOC around the world. Overall, half of the patients included in this study had a delay in genetic assessment and/or surgical rehabilitation. Differences were found in the access of patients with NSOC to genetic assessment and surgery, with a greater disadvantage for those followed at NCFH and needing palatoplasty. Patients with NSOC experienced many barriers to access genetic assessment and surgery through the Brazilian Unified Health System. These results highlight and strengthen the need to establish a transversal health policy, having the CFAH as a reference network able to address the unmet health needs of this population.
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17
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CIANE DE JESUS GOMES VIEIRA
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Level of Physical Activity associated with Asthma, Rhinitis and Eczema in Adolescents in Maceió.
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Líder : MERCIA LAMENHA MEDEIROS
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MIEMBROS DE LA BANCA :
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AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
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FLAVIO TELES DE FARIAS FILHO
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JULIANA CELIA DE FARIAS SANTOS
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MICHELLE JACINTHA CAVALCANTE OLIVEIRA
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NATALIA DE ALMEIDA RODRIGUES
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VALFRIDO LEAO DE MELO NETO
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Data: 26-oct-2023
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Resumen Espectáculo
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Introduction: The prevalence of allergic diseases has demonstrated a continuous growth in recent years (FERREIRA et al., 2021). It is observed that changes in environments and lifestyles, foster the rise of adolescents with chronic diseases such as obesity, hypercholesterolemia, diabetes and may be associated with with asthma, rinitis and atopic dermatitis. The impacts on the physical health of adolescents are not should be the only ones to observe, because the routine and quality of life of these patients are very affected (HATHERILL, 2007), making it difficult for them to be participated in physical activity, not decreasing sedentary behaviors (BLACKMAN; CONAWAY, 2012; chamlin, 2010. CHREN, 2010; SHIN; CHO, 2012; KIM; LEE; RIESCHE, 2020). Objectives: To know the level of physical activity, behavior mental disorders and their association with asthma, rinitis and atopic eczema in patients with adolescents. Methodology: This is a cross-sectional study, through the application of written questionnaires (QE) translated and validated. Adolescents were evaluated, public and private schools, based on the proportion of enrolled. Inclusion criteria in the research were literate adolescents who had cognitive conditions to answer the questionnaires. Exclusion criteria were the correct non-completion questionnaire or if it is incomplete, and those with cardiorespiratory and dermatological conditions. Results: The initial sample was composed of 821 adolescents, 380 (47.3%) boys and 423 (52.6%) girls, 662 of which were (80.6%) from the public network and 159 (19.3%) privately. The prevalence of adolescents with Common Mental Disorders (CMD) was 548 (75.3%), with 311 (83.8%) of girls and 220 (64.9%) of the boys with CMD (p of 0.00). We infer that 428 (73.4%) of public school adolescents and 120 (83.3%) of private adolescents had CMD, demonstrating that being from private school is a risk factor for the presence of CMD (PR: 1.13; CI 1.03 - 1.23; p< 0.01). We saw that 178 (83.9%) from class A to B1 and 370 (72.1%) of classes B2 to E had some type of CMD, and the level of schooling and CMD, 331 (76.4%), had completed high school to higher education Complete, and 185 (74.9%) from illiterate to Incomplete High School. In diseases the prevalence of asthma in adolescents was 145 (18.3%), allergic rhinitis 278 (36.3%), and Eczema 78 (87.6%). Of the adolescents with asthma, 120 (90.2%) presented CMD, demonstrating that those with Asthma may be more likely to
for the development of mental disorders (PR: 1.24; CI 1.15 - 1.34; p< 0.01). Of adolescents with Rinitis, 214 (84.9%), and 97 (12.8%) with Eczema, showed CMD. The prevalence of the level of physical activity (NAF) in adolescents was 321 (39.6%) students 145 (34.6%) of girls reaching 180 minutes per week and 273 (65.3%) below ideal, and among boys, 170 (45.4%) reached the recommendations and 204 (54.5%) stated that they were not active. The NAF of adolescents related to CMDs is not was so significant (PR: 1.01; CI 0.93 - 1.11; p of 0.65). In asthmatic adolescents, 64 (20.7%) were active and 76 (16.1%) in sedentary behavior, in rinitis 112 (34.4) and 162 (35.6%) in sedentary behavior, and with Eczema 57 (59.3%) are 39 (40.6%) reach the ideal weekly duration. About screen time, 343 (79.0%) of the adolescents exposed for more than 3 hours on the screens, reported having CMD, as well as 525 (98.5%) of adolescents who use social networks, expressed signs and symptoms of CMD. Conclusion: rinitis showed a higher prevalence among allergic diseases, as well as sedentary behaviour and mental disorders asthma, rinitis and eczema were identified in adolescents who identified them.
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18
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CAMILA MAIA COSTA DE QUEIROZ SOUTO
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Clinical and molecular characterization of families with Congenital Adrenal Hyperplasia in the Brazilian Unified Health System of Alagoas
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Líder : REGINALDO JOSE PETROLI
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MIEMBROS DE LA BANCA :
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AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
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Fernanda Caroline Soardi
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IRAMIRTON FIGUEREDO MOREIRA
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JOSE ROBERTO DE OLIVEIRA FERREIRA
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JULIANA CELIA DE FARIAS SANTOS
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REGINALDO JOSE PETROLI
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Data: 14-nov-2023
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Resumen Espectáculo
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Introduction: Congenital Adrenal Hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is an inborn error of autosomal recessive metabolism. The clinical form depends on the 21OH residual enzymatic activity. The classic salt-wasting form (CL-PS) causes homeostatic imbalance, leading to death in the neonatal period if not identified and treated in time. HAC-21OHD was incorporated into the National Neonatal Screening Program (PNTN) in Brazil in 2012 and implemented in the Brazilian Unified Health System of Alagoas (SUS-AL) in 2016 and the screened patients are referred to a multidisciplinary team at the reference service of neonatal screening (Serviço de Referência em Triagem Neonatal – SRTN), linked to the Santa Monica Maternity Hospital of the Health Sciences State University of Alagoas (SRTN/MESM/UNCISAL). Before the PNTN, since 2008, CAH patients from SUS-AL have been followed up at the Clinical Genetics Service of the Professor Alberto Antunes University Hospital of the Federal University of Alagoas (SGC/HUPAA/UFAL). Both services are a reference in the care of patients with HAC-21OHD in SUS-AL. Objective: To describe the clinical-molecular profile of HAC-21OHD in SUS-AL, based on the composition of a unique database. Methods: Patients treated from 03/2008 to 02/2022 in both services, with HAC-21OHD clinical and laboratory diagnosis, were included. Data were collected from medical files and molecular reports of CYP21A2 gene analysis. Case series descriptive analysis was performed, with frequency distribution and measures of central tendency and dispersion. Results: The unique database consisted of 45 patients distributed in 40 families, most from the interior of AL (71,1%), and 17,5% reported consanguinity. The age at the 1st consultation ranged from 7 days to 43 years old and 68,2% had genital ambiguity. The CL-PS form was the most frequent, with the c.290-13A/C>G variant being the most prevalent, followed by p.Ser170Lisfs*125. Four patients died from adrenal crisis, one of them, screened by the PNTN, died before the results were published. Conclusion: The data presented here are in accordance with the literature, where the CL-PS form is more frequent, with a higher prevalence of the c.290-13A/C>G variant. However, the high frequency of the p.Ser170Lisfs*125 variant, considered rare, provides evidence of a possible founder effect. The need for decentralization of services to the interior of the state is evident. Deaths from the adrenal crisis have substantially reduced, but there is still a need to improve the flow of service. The recognition of these characteristics is important both at the individual and at the collective level, supporting the construction of specific health policies for these patients.
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19
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BRENDA ALEXIA DE LIMA THEODOSIO
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Interrelationship of nutritional profile, risk of sarcopenia, functional capacity and inflammation in chronic kidney disease
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Líder : MICHELLE JACINTHA CAVALCANTE OLIVEIRA
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MIEMBROS DE LA BANCA :
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ALESSANDRA PLACIDO LIMA LEITE
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ANTONIO FILIPE PEREIRA CAETANO
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AUXILIADORA DAMIANNE PEREIRA VIEIRA DA COSTA E SILVA
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FABIANA ANDREA MOURA
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MICHELLE JACINTHA CAVALCANTE OLIVEIRA
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VALFRIDO LEAO DE MELO NETO
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Data: 19-dic-2023
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Resumen Espectáculo
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Chronic kidney disease (CKD) is a condition in which progressive loss of kidney function occurs, leading to complications and impacting patients' quality of life. The global increase in the number of CKD cases has led to an increase in hemodialysis (HD). However, HD is associated with complications such as nutritional disorders and chronic inflammation. Knowing this, the present study aimed to evaluate the interrelationship between the nutritional profile, risk of sarcopenia, functional capacity and inflammation, in order to identify groups of patients most vulnerable to these associations. This is a cross-sectional study that was conducted with patients on hemodialysis in the nephrology centers of Hospital Veredas, UNIRIM of Hospital Memorial Arthur Ramos and UNIRIM of Hospital do Coração. The work was divided into three stages, being: 1st application of socioeconomic questionnaires and data collection in medical records; 2nd nutritional assessment, including anthropometry and tests to assess functional capacity; 3rd blood collection and measurement of inflammatory cytokines. The initial sample consisted of 148 participants, most of whom were adults (52.7%) and the remaining elderly, with mean ages of approximately 46.6 years and 70.45 years, respectively. Regarding BMI, 41.7% of the participants were overweight, while 16.7% were underweight. Low strength was observed in 9% of the sample and low velocity in 16.8%. The risk of SARC-F sarcopenia was observed in 31% of participants, while SARC-f+CC was observed in 33%. The inflammatory parameters IL-6 and TNF-α were detected in 82.3% and 49.6% of the participants, respectively. Dialysis was considered inadequate in 19.4% of the participants. The mean Kt/V was better in adults compared to the elderly. It was observed that low weight (n=4; 23.5%) and eutrophy (n=10; 58.8%) presented worse gait speed than overweight patients (n=3; 17.7%). The risk of SARC-F sarcopenia was the same in overweight patients (n=9; 47.4%) and in patients with eutrophy (n=9; 47.4%), while underweight patients only represented 5.2% (n=1). When using SARC-F+CC, more eutrophic patients were classified as at risk (n=16; 53.3%), followed by overweight (n=16; 33.3%), and underweight (n=4; 13.4%). These findings may help in the formulation of more targeted and effective therapeutic strategies to care for this group of patients.
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