Banca de QUALIFICAÇÃO: MARIANE SOARES VIEGAS MOURA REZENDE

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : MARIANE SOARES VIEGAS MOURA REZENDE
DATE: 23/03/2023
TIME: 14:30
LOCAL: Instituto de Ciências Farmacêuticas
TITLE:

THE CORRELATION OF VITAMIN D IN THE PATHOPHYSIOLOGY OF PYRYASIS ALBA

KEY WORDS:

Pityriasis alba. Eczematid. Vitamin D. Serum level. hypopigmentation. 1,25(OH)Vitamin D. Cell differentiation. Melanogenesis. Melanocytes. Pathophysiology.

PAGES: 47
BIG AREA: Ciências da Saúde
AREA: Medicina
SUBÁREA: Clínica Médica
SPECIALTY: Dermatologia
SUMMARY:

Introduction: Pityriasis Alba (PA) is a skin condition characterized by asymptomatic, hypopigmented and slightly scaly patches with indistinct margins. The etiology of AP is not well established. The active form of vitamin D is a secosteroid that regulates the calcium level as well as the bone metabolism process, and controls cell proliferation and differentiation. If the intracellular calcium level decreases, it will lead to high levels of the reduced enzyme thioredoxin, which in turn inhibit tyrosinase activity, resulting in inhibition of melanin synthesis. Objective: There are few studies correlating the effect of hypovitaminosis D with the pathogenesis of AP, therefore, the aim of our study was to correlate vitamin D with the pathophysiology of AP. Patients and methods: This was an open, non-randomized, case-control study, where 9 patients over 18 years of age with HL diagnosed clinically in the Clinical Dermatology outpatient clinics of CER III of PAM Salgadinho in Maceió were selected, in an estimated period of 6 months. The control group consisted of 9 patients unaffected by AP or any other hypopigmented disorders. Blood samples were collected from both groups (cases and controls) and circulating serum 25(OH)D levels were measured. Primary variables analyzed were serum vitamin D levels, number and size of lesions, degree of depigmentation and/or presence of erythema, affected region and present symptoms. The secondary variables were the demographic profile of the patients and the tertiary variables were the habits related to bathing. The calculations were performed using the BIOESTAT v.5.3 software and the two-sample “T” test. Data were statistically analyzed using the Mann-Whitney U test, the chi-square test and the Fischer test for primary, secondary and tertiary variables, respectively. An alpha value equal to or less than 0.05 was used to reject the null hypothesis. Results: The results of the evaluation of vitamin D among the cases showed that none of them had a sufficient level of vitamin D and the level varied between 11.1-27.5 ng/ml (mean: 19.666 ± 5.099 ng/ml). Five patients (55.5%) had deficiency and four patients (44.4%) had insufficiency. In the control group, the level ranged from 11.3 to 44.7 ng/ml (mean: 31.777 ± 10.195 ng/ml). Only 01 patient in the control group (11.1%) had vitamin D deficiency, 03 (33.3%) were insufficient and 5 (55.5%) had sufficiency. Comparing the vitamin D levels of both groups, there was a statistically significant difference (p = 0.0071). In the case group, 3 of the 4 patients with severe hypochromia had deficient levels of vitamin D, with 1 being insufficient. Furthermore, of the 6 patients with more than 5 PA lesions, half had vitamin D deficiency and the other half had levels of insufficiency. The only patient with more than 10 lesions had a deficient serum level of vitamin D. Conclusions: It was observed that there is probably an important role of Vitamin D in the pathophysiology of BP. Another finding of this study is that there may be a correlation between the severity and extent of BP with reduced levels of Vitamin D, but further randomized clinical trials will be needed to confirm these hypotheses.

BANKING MEMBERS:
Presidente - 1547952 - EURICA ADELIA NOGUEIRA RIBEIRO
Interno(a) - 1974414 - OLAGIDE WAGNER DE CASTRO
Externo(a) ao Programa - 3509820 - MARIA ALINE BARROS FIDELIS DE MOURA