Banca de QUALIFICAÇÃO: SERGIO LOPES DA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : SERGIO LOPES DA SILVA
DATE: 30/09/2021
TIME: 14:00
LOCAL: google meet
TITLE:

INFLUENCE OF SCHWANN CELLS ON THE PROGRESSION OF PROSTATE CANCER

KEY WORDS:

Carcinogenesis
Prostate cancer
Metastasis
Schwann cells

PAGES: 35
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

The phenomenon of carcinogenesis is a complex process that occurs through multiple genetic events that alter the normal functions of oncogenes and tumor suppressor genes. Studies have shown that Schwann cells participate in the tumor microenvironment, producing several factors that benefit cancer cells. During this process, Schwann cells are undifferentiated and aid the process of cancer cell proliferation. These cells then migrate to the region near the tumor tissue and aid the development of the neoplastic cell. In this context, the aim of this study was to evaluate the influence of Schwann cells on prostate cancer. We performed a bioinformatics view and observed that the "neuroactive connecting-receptor interaction" was positively regulated in prostate cancer. The "p53 signaling pathway" is active, since CCNE1, CDKN2A and PERP are increased. specific miRNAs inactivate the pathway of "guidance of axons", aiming at the ROBO2 and SLIT2 genes. Both genes are also associated with inhibition of schwann cell migration. In addition, GFAP and GAP43 are overexpressed, leading to dedifferentiation of Schwann cells. Both Schwann and neoplastic cells are stimulated via phosphorylation cascade to proliferate and migrate. The results show that schwann cell dedifferentiation and proliferation are induced by neoplastic tissue; consequently, Schwann cells produce different factors that will participate in various tumor progression processes. These processes may also be involved in tumor invasion in perineural tissue in prostate neoplasia.

BANKING MEMBERS:
Externa ao Programa - 2363781 - AMANDA KARINE BARROS FERREIRA RODRIGUES
Externa à Instituição - BRUNA DEL VECHIO KOIKE
Presidente - 2361727 - CARLOS ALBERTO DE CARVALHO FRAGA
Interna - 2269479 - CAROLINNE DE SALES MARQUES
Externa ao Programa - 2390962 - JUSSARA ALMEIDA DE OLIVEIRA BAGGIO