Banca de QUALIFICAÇÃO: MICAELY CRISTINA DOS SANTOS TENORIO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : MICAELY CRISTINA DOS SANTOS TENORIO
DATE: 15/01/2024
TIME: 09:00
LOCAL: google meet
TITLE:

SUPPLEMENTATION OF N-ACETYL-CYSTEINE (NAC) IN PREGNANT WOMEN WITH PRE-ECLAMPSIA: ITS IMPACT ON THE BIOMARKERS OF REDOX IMBALANCE AND INFLAMMATION 

KEY WORDS:

Oxidative stress; Antioxidants; Glutathione; Pregnancy.

 

 

PAGES: 197
BIG AREA: Multidisciplinar
AREA: Biotecnologia
SUBÁREA: Biotecnologia em Saúde
SUMMARY:

Introduction: Pre-eclampsia is a syndrome of multisystemic nature with multifactorial pathophysiology, including oxidative stress and inflammation. Objective: To evaluate the impact of NAC supplementation on biomarkers of redox imbalance and inflammation in pregnant women with PE. Objective: To evaluate the impact of NAC supplementation on biomarkers of redox imbalance and inflammation in pregnant women with PE. Methods: This is a double-blind, randomized, placebo-controlled clinical trial study carried out in prenatal care at a university hospital in Maceió-Alagoas from 2021 to 2023, including women diagnosed with pre-eclampsia between the 24th and 32nd weeks of gestation. After being included in the research, pregnant women were randomly allocated into two groups: intervention (supplemented with N-acetylcysteine) or control (supplemented with placebo). A standardized form containing data was applied: socioeconomic, clinical, cultural, personal, and anthropometric. At baseline and before delivery, blood samples were collected to quantify biomarkers of redox imbalance (catalase - CAT; malondialdehyde - MDA; hydrogen peroxide, H2O2; superoxide dismutase - SOD) and inflammation (myeloperoxidase, MPO; interleukin (IL)-10; IL-17; IL-22; and tumor necrosis factor alpha, TNF-α). Biomarkers were evaluated using a mixed ANOVA, adopting a significance level of 5%. Results: 62 pregnant women were initially included in the research. Of these, 11 (17.4%) withdrew from the trial, totaling a final sample of 51 women, 26 from the placebo group, and 25 from the NAC group. The mean time of capsule use in the placebo group was 74.76 (± 26.71 SD) and in the NAC group it was 86.68 (±30.41 SD) days (p = 0.45). Regarding the assessment of stress and inflammation biomarkers, no statistically significant differences were found, before and after supplementation in both groups of: H2O2, SOD, CAT, MDA, MPO, IL-10, IL-17 and IL-22 and TNF -α. Conclusion: Oral NAC supplementation during pregnancy appears to be safe, viable and inexpensive, but our findings were not consistent in evaluating improvements in oxidative stress and inflammation parameters. There may be a role for the use of NAC and improvement of oxidative stress and inflammation in PE, but this remains unexplored. Future studies of longer duration and a greater number of participants are needed to confirm the validity of our finding.

COMMITTEE MEMBERS:
Presidente - 2120103 - MARILIA OLIVEIRA FONSECA GOULART
Interno(a) - 426640 - FABIANE CAXICO DE ABREU GALDINO
Interno(a) - 2272670 - ALINE CAVALCANTI DE QUEIROZ
Externo(a) ao Programa - 2022362 - ANA CATARINA REZENDE LEITE - UFALExterno(a) ao Programa - 1851685 - ALANE CABRAL MENEZES DE OLIVEIRA - UFALExterno(a) ao Programa - 1130431 - NASSIB BEZERRA BUENO - UFALExterno(a) à Instituição - ANTONIO MARCUS DE ANDRADE PAES - UFMA