Banca de QUALIFICAÇÃO: ILZA FERNANDA BARBOZA DUARTE RODRIGUES

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : ILZA FERNANDA BARBOZA DUARTE RODRIGUES
DATE: 06/09/2023
TIME: 09:00
LOCAL: Remoto
TITLE:

DEVELOPMENT OF NUTRACEUTICS CONTAINING EXTRACT OF RED PROPOLIS AND NANOPARTICLES/NANOCOMPOSITES OBTAINED BY IONIC GELLING

KEY WORDS:

Propolis. Phenolic compounds. Ionic gelation. Microencapsulation. nanoparticles.

PAGES: 58
BIG AREA: Multidisciplinar
AREA: Biotecnologia
SUBÁREA: Biotecnologia em Saúde
SUMMARY:

Nutraceuticals are foods or parts of foods that will provide health and pharmacological benefits, including the prevention and/or treatment of disease and may range from isolated nutrients to engineered products. A natural product classified as food is red propolis, which has been studied all over the world and is widely used in the form of an extract, in human therapy, due to its pharmacological properties. However, propolis is quite unstable to factors such as oxygen, light, heat and humidity, which compromises its functional activity, requiring technological alternatives to improve its conservation and encapsulation methods can be used in order to increase its stability when exposed to adverse conditions. Propolis has also been used as a material for the production of nanostructured systems, including inorganic nanoparticles, such as metallic ones. Currently, zinc oxide and silver have been used in the production of nanostructured compounds, which have attracted the attention of researchers from different areas. In this context, the work aims to develop nutraceuticals from the encapsulation of red propolis, zinc oxide nanocrystals (NCsPV/ZnO) and zinc and silver oxide nanocomposites (NCs-PV/ZnOAg) by the ionic gelation process. In this study, six formulations called F1 (alginate), F2 (alginate+ZnO), F3 (alginate+ZnOAg), F4 (alginate+PV), F5 (alginate+PV+ZnO) and F6 (alginate+PV+ZnOAg) were developed. ) from the ionic gelling method using sodium alginate (2%) and calcium chloride (3%). Subsequently, the average weight of the microcapsules was evaluated, obtaining similar values; quantified the encapsulation efficiency, where it was verified that F4, F5 and F6 presented efficiency of 92.51, 94.12 and 95.92%, respectively; the antioxidant activity was evaluated, in which F4 and F5 obtained the best results; for antimicrobial activity against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922) and Candida albicans (ATCC 90028) strains, F4, F5 and F6 had the best inhibition halos; characterization by SEM revealed that F5 and F6 resulted in microcapsules with a more uniform shape and surface; the evaluation for degradation and compatibility by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), revealed homogeneity and compatibility for formulations F4 and F5.In this way, it was possible to conclude that the encapsulation technique is promising, allowing the successful development of the study, in addition to offering a basis to expand the scope of the research.

COMMITTEE MEMBERS:
Interno(a) - 1347651 - ANGELINA BOSSI FRAGA
Interno(a) - 426640 - FABIANE CAXICO DE ABREU GALDINO
Interno(a) - 2120103 - MARILIA OLIVEIRA FONSECA GOULART
Externo(a) ao Programa - 1553302 - IRINALDO DINIZ BASILIO JUNIOR - UFALExterno(a) ao Programa - 1488396 - TICIANO GOMES DO NASCIMENTO - UFAL